Gene/Proteome Database (LMPD)

LMPD ID
LMP008940
Gene ID
36384
Species
Drosophila melanogaster (Drosophila)
Gene Name
G protein alpha q subunit
Gene Symbol
Galphaq
Synonyms
CG17759; dGaalpha; DGalphaq; DGalpha[[q]]; dgq; dGq; Dgq; DGq; dGqa-49b; dgqalpha; dGqalpha; DGqalpha; dGqalpha-3; dGqalpha-49b; dG[[alphaq]]; dG[[q]]alpha; Dmel\CG17759; DmGalpha[[q]]; Dromel_CG17759_galpha49b_mORF; G alpha 49B; G?q; Galpha; galpha49B; Galpha49b; Galpha49B; Galpha[[q]]; Gaq; Gq; Gqa-3; Gqalpha; Gqalphae; Gqalpha[[e]]; Gqalpha{e}; G[q]; G[[alphaq]]; G[[a]]q; G[[qalpha]]; G[[q]]; G[[q]]alpha; sast
Chromosome
2R
Map Location
49B8-49B9

Proteins

G protein alpha q subunit, isoform A
Refseq ID NP_725191
Protein GI 24653107
UniProt ID P23625
mRNA ID NM_165919
Length 353
RefSeq Status REVIEWED
MECCLSEEAKEQKRINQEIEKQLRRDKRDARRELKLLLLGTGESGKSTFIKQMRIIHGSGYSDEDKRGYIKLVFQNIFMAMQSMIKAMDMLKISYGQGEHSELADLVMSIDYETVTTFEDPYLNAIKTLWDDAGIQECYDRRREYQLTDSAKYYLKDLDRVAQPAYLPTEQDILRVRVPTTGIIEYPFDLEEIRFRMVDVGGQRSERRKWIHCFENVTSIIFLVALSEYDQILFESDNENRMEESKALFRTIITYPWFQNSSVILFLNKKDLLEEKIMYSHLVDYFPEYDGPQRDAITAREFILRMFVDLNPDSEKIIYSHFTCATDTENIRFVFAAVKDTILQSNLKEYNLV
G protein alpha q subunit, isoform C
Refseq ID NP_725193
Protein GI 24653111
UniProt ID P23625
mRNA ID NM_165921
Length 353
RefSeq Status REVIEWED
Protein sequence is identical to GI:24653107 (mRNA isoform)
G protein alpha q subunit, isoform D
Refseq ID NP_725196
Protein GI 24653117
UniProt ID P23625
mRNA ID NM_165924
Length 353
RefSeq Status REVIEWED
MECCLSEEAKEQKRINQEIEKQLRRDKRDARRELKLLLLGTGESGKSTFIKQMRIIHGSGYSDEDKRGYIKLVFQNIFMAMQSMIKAMDMLKISYGQGEHSELADLVMSIDYETVTTFEDPYLNAIKTLWDDAGIQECYDRRREYQLTDSAKYYLSDLARIEQADYLPTEQDILRARVPTTGILEYPFDLDGIVFRMVDVGGQRSERRKWIHCFENVTSIIFLVALSEYDQILFESDNENRMEESKALFRTIITYPWFQNSSVILFLNKKDLLEEKIMYSHLVDYFPEYDGPKQDHAAAKQFVLKKYLACNPDPERQCYSHFTTATDTENIKLVFCAVKDTIMQNALKEFNLG
G protein alpha q subunit, isoform E
Refseq ID NP_725194
Protein GI 24653113
UniProt ID P23625
mRNA ID NM_165922
Length 353
RefSeq Status REVIEWED
Protein sequence is identical to GI:24653107 (mRNA isoform)
G protein alpha q subunit, isoform G
Refseq ID NP_725195
Protein GI 24653115
UniProt ID P23625
mRNA ID NM_165923
Length 353
RefSeq Status REVIEWED
Protein sequence is identical to GI:24653107 (mRNA isoform)
G protein alpha q subunit, isoform J
Refseq ID NP_725192
Protein GI 442623465
UniProt ID P23625
mRNA ID NM_165920
Length 396
RefSeq Status REVIEWED
MECCLSEEAKEQKRINQEIEKQLRRDKRDARRELKLLLLGTGESGKSTFIKQMRIIHGSGYSDEDKRGYIKLVFQNIFMAMQSMIKAMDMLKISYGQGEHSELADLVMSIDYETVTTFEDPYLNAIKTLWDDAGIQECYDRRREYQLTDSAKYYLKDLDRVAQPAYLPTEQDILRVRVPTTGIIEYPFDLEEIRFSYLSDLARIEQADYLPTEQDILRARVPTTGILEYPFDLDGIVFRMVDVGGQRSERRKWIHCFENVTSIIFLVALSEYDQILFESDNENRMEESKALFRTIITYPWFQNSSVILFLNKKDLLEEKIMYSHLVDYFPEYDGPQRDAITAREFILRMFVDLNPDSEKIIYSHFTCATDTENIKLVFCAVKDTIMQNALKEFNLG
G protein alpha q subunit, isoform K
Refseq ID NP_725197
Protein GI 386767821
UniProt ID P23625
mRNA ID NM_165925
Length 353
RefSeq Status REVIEWED
Protein sequence is identical to GI:24653107 (mRNA isoform)

Gene Information

Entrez Gene ID
36384
Gene Name
G protein alpha q subunit
Gene Symbol
Galphaq
Species
Drosophila melanogaster

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005834 ISS:FlyBase C heterotrimeric G-protein complex
GO:0016027 IDA:FlyBase C inaD signaling complex
GO:0005886 IDA:FlyBase C plasma membrane
GO:0016028 IDA:FlyBase C rhabdomere
GO:0031683 IBA:RefGenome F G-protein beta/gamma-subunit complex binding
GO:0001664 IBA:RefGenome F G-protein coupled receptor binding
GO:0005525 IEA:UniProtKB-KW F GTP binding
GO:0003924 IMP:FlyBase F GTPase activity
GO:0046872 IEA:UniProtKB-KW F metal ion binding
GO:0004871 IBA:RefGenome F signal transducer activity
GO:0007202 IGI:FlyBase P activation of phospholipase C activity
GO:0007188 IBA:RefGenome P adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0016199 IMP:FlyBase P axon midline choice point recognition
GO:0071244 IMP:FlyBase P cellular response to carbon dioxide
GO:0006897 IMP:FlyBase P endocytosis
GO:0007629 IGI:FlyBase P flight behavior
GO:0016060 IMP:FlyBase P metarhodopsin inactivation
GO:0002385 IMP:FlyBase P mucosal immune response
GO:0046673 IMP:FlyBase P negative regulation of compound eye retinal cell programmed cell death
GO:0060158 IBA:RefGenome P phospholipase C-activating dopamine receptor signaling pathway
GO:0007602 IDA:FlyBase P phototransduction
GO:0016056 IMP:FlyBase P rhodopsin mediated signaling pathway
GO:0007608 IMP:FlyBase P sensory perception of smell
GO:0030322 IGI:FlyBase P stabilization of membrane potential
GO:0043052 IDA:FlyBase P thermotaxis
GO:0007601 IEA:UniProtKB-KW P visual perception

KEGG Pathway Links

KEGG Pathway ID Description
dme04745 Phototransduction - fly
ko04745 Phototransduction - fly

REACTOME Pathway Links

REACTOME Pathway ID Description
6226707 ADP signalling through P2Y purinoceptor 1
6226662 Acetylcholine regulates insulin secretion
6226663 Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion
6226664 Free fatty acids regulate insulin secretion
6226204 G alpha (q) signalling events
6226200 GPCR downstream signaling
6226119 Gastrin-CREB signalling pathway via PKC and MAPK
6226203 Hemostasis
6226181 Integration of energy metabolism
6225882 Metabolism
6226202 Platelet activation, signaling and aggregation
6226261 Regulation of insulin secretion
6225975 Signal Transduction
6226708 Signal amplification
6225984 Signaling by GPCR

Domain Information

InterPro Annotations

Accession Description
IPR011025 G protein alpha subunit, helical insertion
IPR000654 Gprotein_alpha_Q
IPR001019 Guanine nucleotide binding protein (G-protein), alpha subunit
IPR027417 P-loop containing nucleoside triphosphate hydrolase

UniProt Annotations

Entry Information

Gene Name
G protein alpha q subunit
Protein Entry
GNAQ_DROME
UniProt ID
P23625
Species
Drosophila

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Comment=Additional isoforms seem to exist.; Name=D; Synonyms=F; IsoId=P23625-1; Sequence=Displayed; Name=A; Synonyms=B, C, E, G, H; IsoId=P23625-2; Sequence=VSP_001835, VSP_001836;
Function Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Could be the transducin analog, an amplifier and one of the transducers of a visual impulse that performs the coupling between opsin and cGMP-phosphodiesterase. Could mediate a subset of olfactory and gustatory responses. {ECO:0000269|PubMed:2125225, ECO:0000269|PubMed:8524786}.
Similarity Belongs to the G-alpha family. G(q) subfamily. {ECO:0000305}.
Tissue Specificity Isoform D is expressed only in the retina and ocellus of the adult head. Isoform A is expressed in chemosensory cells of the olfactory and taste structures, including a subset of olfactory and gustatory neurons, and in cells of the central nervous system, including neurons in the lamina ganglionaris. {ECO:0000269|PubMed:2125225, ECO:0000269|PubMed:8524786}.

Identical and Related Proteins

Unique RefSeq proteins for LMP008940 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
24653107 RefSeq NP_725191 353 G protein alpha q subunit, isoform A
24653117 RefSeq NP_725196 353 G protein alpha q subunit, isoform D
442623465 RefSeq NP_725192 396 G protein alpha q subunit, isoform J

Identical Sequences to LMP008940 proteins

Reference Database Accession Length Protein Name
GI:24653117 GenBank AAA28460.1 353 retinal specific G-alpha protein [Drosophila melanogaster]
GI:24653117 GenBank ABC86331.1 353 IP15229p [Drosophila melanogaster]
GI:24653117 GenBank ABH96449.1 353 Sequence 12 from patent US 7067277
GI:24653107 GenBank ABH96450.1 353 Sequence 13 from patent US 7067277
GI:24653107 GenBank ACL84308.1 353 Galpha49B-PA, partial [synthetic construct]
GI:24653117 gnl FlyBase 353 G protein alpha q subunit, isoform D [Drosophila melanogaster]
GI:24653107 gnl FlyBase 353 G protein alpha q subunit, isoform K [Drosophila melanogaster]
GI:442623465 gnl FlyBase 396 G protein alpha q subunit, isoform J [Drosophila melanogaster]
GI:24653107 RefSeq NP_725194.1 353 G protein alpha q subunit, isoform E [Drosophila melanogaster]
GI:24653107 RefSeq NP_725195.1 353 G protein alpha q subunit, isoform G [Drosophila melanogaster]
GI:24653107 RefSeq NP_725197.2 353 G protein alpha q subunit, isoform K [Drosophila melanogaster]
GI:24653117 SwissProt P23625.2 353 RecName: Full=G protein alpha q subunit; AltName: Full=Guanine nucleotide-binding protein G(q) subunit alpha; AltName: Full=Guanine nucleotide-binding protein alpha-q; AltName: Full=dGQalpha [Drosophila melanogaster]

Related Sequences to LMP008940 proteins

Reference Database Accession Length Protein Name
GI:24653117 EMBL CAB76453.1 353 guanine nucleotide-binding protein alpha subunit [Calliphora vicina]
GI:24653107 GenBank ABH96461.1 353 Sequence 41 from patent US 7067277
GI:442623465 GenBank EDV56284.1 432 GG20320 [Drosophila erecta]
GI:24653107 GenBank EDW00991.1 353 GH21190 [Drosophila grimshawi]
GI:24653107 GenBank EDW09380.1 353 GI20476 [Drosophila mojavensis]
GI:442623465 GenBank EDW90737.1 432 GE12481 [Drosophila yakuba]
GI:442623465 GenBank EDX06804.1 432 GD10904 [Drosophila simulans]
GI:24653107 GenBank ENO01765.1 353 GA14650, isoform B [Drosophila pseudoobscura pseudoobscura]
GI:24653117 GenBank ENO01766.1 353 GA14650, isoform D [Drosophila pseudoobscura pseudoobscura]
GI:24653117 GenBank JAC47796.1 353 Guanine nucleotide-binding protein G(q) subunit alpha [Bactrocera dorsalis]
GI:24653117 GenBank JAC47797.1 353 Guanine nucleotide-binding protein G(q) subunit alpha [Bactrocera dorsalis]
GI:442623465 RefSeq XP_001975884.1 432 GG20320 [Drosophila erecta]
GI:24653107 RefSeq XP_002005445.1 353 GI20476 [Drosophila mojavensis]
GI:442623465 RefSeq XP_002091025.1 432 GE12481 [Drosophila yakuba]
GI:442623465 RefSeq XP_002081219.1 432 GD10904 [Drosophila simulans]
GI:24653107 RefSeq XP_004444352.1 353 GA14650, isoform B [Drosophila pseudoobscura pseudoobscura]
GI:24653117 RefSeq XP_004444353.1 353 GA14650, isoform D [Drosophila pseudoobscura pseudoobscura]
GI:24653117 RefSeq XP_005180085.1 353 PREDICTED: guanine nucleotide-binding protein G(q) subunit alpha-like isoform X4 [Musca domestica]