Gene/Proteome Database (LMPD)

LMPD ID
LMP008975
Gene ID
36073
Species
Drosophila melanogaster (Drosophila)
Gene Name
Hormone receptor-like in 46
Gene Symbol
Hr46
Synonyms
12.6; 2.4; CG11823; CG12208; CG33183; D; dHR3; Dhr3; DHR3; Dmel\CG33183; DmRORalpha; Hr3; HR3; hr46; l(2)46CFi; l(2)k09242; NR1F4
Chromosome
2R
Map Location
46F5-46F7

Proteins

hormone receptor-like in 46, isoform A
Refseq ID NP_788303
Protein GI 28573924
UniProt ID P31396
mRNA ID NM_176123
Length 487
RefSeq Status REVIEWED
MYTQRMFDMWSSVTSKLEAHANNLGQSNVQSPAGQNNSSGSIKAQIEIIPCKVCGDKSSGVHYGVITCEGCKGFFRRSQSSVVNYQCPRNKQCVVDRVNRNRCQYCRLQKCLKLGMSRDAVKFGRMSKKQREKVEDEVRFHRAQMRAQSDAAPDSSVYDTQTPSSSDQLHHNNYNSYSGGYSNNEVGYGSPYGYSASVTPQQTMQYDISADYVDSTTYEPRSTIIDPEFISHADGDINDVLIKTLAEAHANTNTKLEAVHDMFRKQPDVSRILYYKNLGQEELWLDCAEKLTQMIQNIIEFAKLIPGFMRLSQDDQILLLKTGSFELAIVRMSRLLDLSQNAVLYGDVMLPQEAFYTSDSEEMRLVSRIFQTAKSIAELKLTETELALYQSLVLLWPERNGVRGNTEIQRLFNLSMNAIRQELETNHAPLKGDVTVLDTLLNNIPNFRDISILHMESLSKFKLQHPNVVFPALYKELFSIDSQQDLT
hormone receptor-like in 46, isoform C
Refseq ID NP_788301
Protein GI 28573920
UniProt ID A1Z858
mRNA ID NM_176121
Length 694
RefSeq Status REVIEWED
MASLLGSAPPAQILANQPIIVKIEPTQSFHIVDEGDTRVLSLPLSDADKLGASWIDLKDIAGLQAGGGATLLDVCFEQANEDGTIIATVQPDLENELEAELKAEGEPEDETEPEPPAPKRLATTRPAQSRPNNQQVKFLSDPPALARSSSFSSLSSFSSISNISSVCKNMASNTSQEGSLKRTKERTPPPMPPLTTHKPAATTTATSATSAAAATSAATASATATSARENSREHSSSSSGSNGAMTAQIEIIPCKVCGDKSSGVHYGVITCEGCKGFFRRSQSSVVNYQCPRNKQCVVDRVNRNRCQYCRLQKCLKLGMSRDAVKFGRMSKKQREKVEDEVRFHRAQMRAQSDAAPDSSVYDTQTPSSSDQLHHNNYNSGGYSNNEVGYGSPYGYSASVTPQQTMQYDISADYVDSTTYEPRSTIIDPEFISHADGDINDVLIKTLAEAHANTNTKLEAVHDMFRKQPDVSRILYYKNLGQEELWLDCAEKLTQMIQNIIEFAKLIPGFMRLSQDDQILLLKTGSFELAIVRMSRLLDLSQNAVLYGDVMLPQEAFYTSDSEEMRLVSRIFQTAKSIAELKLTETELALYQSLVLLWPERNGVRGNTEIQRLFNLSMNAIRQELETNHAPLKGDVTVLDTLLNNIPNFRDISILHMESLSKFKLQHPNVVFPALYKELFSIDSQQDLT
hormone receptor-like in 46, isoform D
Refseq ID NP_001097256
Protein GI 161076500
UniProt ID A8DY91
mRNA ID NM_001103786
Length 456
RefSeq Status REVIEWED
MRLLNPDNMPSTIRAQIEIIPCKVCGDKSSGVHYGVITCEGCKGFFRRSQSSVVNYQCPRNKQCVVDRVNRNRCQYCRLQKCLKLGMSRDAVKFGRMSKKQREKVEDEVRFHRAQMRAQSDAAPDSSVYDTQTPSSSDQLHHNNYNSGGYSNNEVGYGSPYGYSASVTPQQTMQYDISADYVDSTTYEPRSTIIDPEFISHADGDINDVLIKTLAEAHANTNTKLEAVHDMFRKQPDVSRILYYKNLGQEELWLDCAEKLTQMIQNIIEFAKLIPGFMRLSQDDQILLLKTGSFELAIVRMSRLLDLSQNAVLYGDVMLPQEAFYTSDSEEMRLVSRIFQTAKSIAELKLTETELALYQSLVLLWPERNGVRGNTEIQRLFNLSMNAIRQELETNHAPLKGDVTVLDTLLNNIPNFRDISILHMESLSKFKLQHPNVVFPALYKELFSIDSQQDLT
hormone receptor-like in 46, isoform E
Refseq ID NP_788302
Protein GI 320543744
UniProt ID Q8SXA4
mRNA ID NM_176122
Length 874
RefSeq Status REVIEWED
MNQVKVPRDLLLIQQAKPAGGSKSSSGGPTYIGTDAATAAAVANLRSKVPSISIIPLPVSTTIVARSGSGASGTGGSGGAPPALPQLIQSSRSVSTKSTGTSPPLAFITEGSGTSGAPALTLLPRPQQQHQYQQTDKCTVLKLDVLKQQSGVAANSSSNTYLQIEQQLSELEAADEEEENMASLLGSAPPAQILANQPIIVKIEPTQSFHIVDEGDTRVLSLPLSDADKLGASWIDLKDIAGLQAGGGATLLDVCFEQANEDGTIIATVQPDLENELEAELKAEGEPEDETEPEPPAPKRLATTRPAQSRPNNQQVKFLSDPPALARSSSFSSLSSFSSISNISSVCKNMASNTSQEGSLKRTKERTPPPMPPLTTHKPAATTTATSATSAAAATSAATASATATSARENSREHSSSSSGSNGAMTAQIEIIPCKVCGDKSSGVHYGVITCEGCKGFFRRSQSSVVNYQCPRNKQCVVDRVNRNRCQYCRLQKCLKLGMSRDAVKFGRMSKKQREKVEDEVRFHRAQMRAQSDAAPDSSVYDTQTPSSSDQLHHNNYNSGGYSNNEVGYGSPYGYSASVTPQQTMQYDISADYVDSTTYEPRSTIIDPEFISHADGDINDVLIKTLAEAHANTNTKLEAVHDMFRKQPDVSRILYYKNLGQEELWLDCAEKLTQMIQNIIEFAKLIPGFMRLSQDDQILLLKTGSFELAIVRMSRLLDLSQNAVLYGDVMLPQEAFYTSDSEEMRLVSRIFQTAKSIAELKLTETELALYQSLVLLWPERNGVRGNTEIQRLFNLSMNAIRQELETNHAPLKGDVTVLDTLLNNIPNFRDISILHMESLSKFKLQHPNVVFPALYKELFSIDSQQDLT
hormone receptor-like in 46, isoform F
Refseq ID NP_001246236
Protein GI 386767645
UniProt ID P31396
mRNA ID NM_001259307
Length 487
RefSeq Status REVIEWED
MYTQRMFDMWSSVTSKLEAHANNLGQSNVQSPAGQNNSSGSIKAQIEIIPCKVCGDKSSGVHYGVITCEGCKGFFRRSQSSVVNYQCPRNKQCVVDRVNRNRCQYCRLQKCLKLGMSRDAVKFGRMSKKQREKVEDEVRFHRAQMRAQSDAAPDSSVYDTQTPSSSDQLHHNNYNSYSGGYSNNEVGYGSPYGYSASVTPQQTMQYDISADYVDSTTYEPRSTIIDPEFISHADGDINDVLIKTLAEAHANTNTKLEAVHDMFRKQPDVSRILYYKNLGQEELWLDCAEKLTQMIQNIIEFAKLIPGFMRLSQDDQILLLKTGSFELAIVRMSRLLDLSQNAVLYGDVMLPQEAFYTSDSEEMRLVSRIFQTAKSIAELKLTETELALYQSLVLLWPERNGVRGNTEIQRLFNLSMNAIRQELETNHAPLKGDVTVLDTLLNNIPNFRDISILHMESLSKFKLQHPNVVFPALYKELFSIDSQQDLT
hormone receptor-like in 46, isoform G
Refseq ID NP_001246237
Protein GI 386767647
UniProt ID P31396
mRNA ID NM_001259308
Length 372
RefSeq Status REVIEWED
MSRDAVKFGRMSKKQREKVEDEVRFHRAQMRAQSDAAPDSSVYDTQTPSSSDQLHHNNYNSYSGGYSNNEVGYGSPYGYSASVTPQQTMQYDISADYVDSTTYEPRSTIIDPEFISHADGDINDVLIKTLAEAHANTNTKLEAVHDMFRKQPDVSRILYYKNLGQEELWLDCAEKLTQMIQNIIEFAKLIPGFMRLSQDDQILLLKTGSFELAIVRMSRLLDLSQNAVLYGDVMLPQEAFYTSDSEEMRLVSRIFQTAKSIAELKLTETELALYQSLVLLWPERNGVRGNTEIQRLFNLSMNAIRQELETNHAPLKGDVTVLDTLLNNIPNFRDISILHMESLSKFKLQHPNVVFPALYKELFSIDSQQDLT
hormone receptor-like in 46, isoform H
Refseq ID NP_001260854
Protein GI 442623145
UniProt ID P31396
mRNA ID NM_001273925
Length 529
RefSeq Status REVIEWED
MYTQRMFDMWSSVTSKLEAHANNLGQSNVQSPAGQNNSSGSIKAQIEIIPCKVCGDKSSGVHYGVITCEGCKGFFRRSQSSVVNYQCPRNKQCVVDRVNRNRCQYCRLQKCLKLGMSRDAVKFGRMSKKQREKVEDEVRFHRAQMRAQSDAAPDSSVYDTQTPSSSDQLHHNNYNSYSGGYSNNEVGYGSPYGYSASVTPQQTMQYDISADYVDSTTYEPRSTIIDPEFISHADGDINDVLIKTLAEAHANTNTKLEAVHDMFRKQPDVSRILYYKNLGQEELWLDCAEKLTQMIQNIIEFAKLIPGFMRLSQDDQILLLKTGSFELAIVRMSRLLDLSQNAVLYGDVMLPQEAFYTSDSEEMRLVSRIFQTAKSIAELKLTETELALYQSLVLLWPERNGVRGNTEIQRLFNLSMNAIRQELETNHAPLKGDVTVLDTLLNNIPNFRDISILHMESLSKFKLQHPNVVFPALYKELFSIDSQQDLTXQEQQPFLETTADDVAEDAAAAGCVLPPVAPPAGQQPALLED

Gene Information

Entrez Gene ID
36073
Gene Name
Hormone receptor-like in 46
Gene Symbol
Hr46
Species
Drosophila melanogaster

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005634 IDA:FlyBase C nucleus
GO:0000977 IDA:FlyBase F RNA polymerase II regulatory region sequence-specific DNA binding
GO:0004879 IDA:FlyBase F ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0003707 IEA:InterPro F steroid hormone receptor activity
GO:0004887 IEA:InterPro F thyroid hormone receptor activity
GO:0008270 IEA:InterPro F zinc ion binding
GO:0030522 IDA:GOC P intracellular receptor signaling pathway
GO:0007552 TAS:FlyBase P metamorphosis
GO:0016319 IMP:FlyBase P mushroom body development
GO:0000122 IDA:FlyBase P negative regulation of transcription from RNA polymerase II promoter
GO:0045944 IDA:FlyBase P positive regulation of transcription from RNA polymerase II promoter
GO:0040034 TAS:FlyBase P regulation of development, heterochronic

REACTOME Pathway Links

REACTOME Pathway ID Description
6225926 Gene Expression
6226331 Generic Transcription Pathway
6226616 Nuclear Receptor transcription pathway

Domain Information

InterPro Annotations

Accession Description
IPR008946 Nuclear hormone receptor, ligand-binding
IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR001723 Steroid hormone receptor
IPR001728 Thyroid hormone receptor
IPR013088 Zinc finger, NHR/GATA-type
IPR001628 Zinc finger, nuclear hormone receptor-type

UniProt Annotations

Entry Information

Gene Name
Hormone receptor-like in 46
Protein Entry
A8DY91_DROME
UniProt ID
Q8SXA4
Species
Drosophila

Comments

Comment Type Description
Function Putative receptor whose ligand is not yet known.
Induction The expression of this protein is developmentally regulated showing peaks at midembryogenesis. HR3 transcription is ecdysone-induced.
Similarity Belongs to the nuclear hormone receptor family. NR1 subfamily. {ECO:0000305}.
Similarity Contains 1 nuclear receptor DNA-binding domain. {ECO:0000255|PROSITE-ProRule:PRU00407}.
Subcellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00407}.

Identical and Related Proteins

Unique RefSeq proteins for LMP008975 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
28573924 RefSeq NP_788303 487 hormone receptor-like in 46, isoform A
28573920 RefSeq NP_788301 694 hormone receptor-like in 46, isoform C
161076500 RefSeq NP_001097256 456 hormone receptor-like in 46, isoform D
320543744 RefSeq NP_788302 874 hormone receptor-like in 46, isoform E
386767645 RefSeq NP_001246236 487 hormone receptor-like in 46, isoform F
386767647 RefSeq NP_001246237 372 hormone receptor-like in 46, isoform G
442623145 RefSeq NP_001260854 529 hormone receptor-like in 46, isoform H

Identical Sequences to LMP008975 proteins

Reference Database Accession Length Protein Name
GI:28573924 GenBank EDW89624.1 487 GE21721 [Drosophila yakuba]
GI:386767645 GenBank EDW89624.1 487 GE21721 [Drosophila yakuba]
GI:386767645 GenBank AEY64286.1 487 FI17818p1 [Drosophila melanogaster]
GI:28573924 GenBank AEY64286.1 487 FI17818p1 [Drosophila melanogaster]
GI:28573924 gnl FlyBase 487 hormone receptor-like in 46, isoform A [Drosophila melanogaster]
GI:386767645 gnl FlyBase 487 hormone receptor-like in 46, isoform A [Drosophila melanogaster]
GI:28573920 gnl FlyBase 694 hormone receptor-like in 46, isoform C [Drosophila melanogaster]
GI:161076500 gnl FlyBase 456 hormone receptor-like in 46, isoform D [Drosophila melanogaster]
GI:320543744 gnl FlyBase 874 hormone receptor-like in 46, isoform E [Drosophila melanogaster]
GI:386767645 gnl FlyBase 487 hormone receptor-like in 46, isoform F [Drosophila melanogaster]
GI:28573924 gnl FlyBase 487 hormone receptor-like in 46, isoform F [Drosophila melanogaster]
GI:386767647 gnl FlyBase 372 hormone receptor-like in 46, isoform G [Drosophila melanogaster]
GI:442623145 gnl FlyBase 529 hormone receptor-like in 46, isoform H [Drosophila melanogaster]
GI:386767645 RefSeq NP_788303.1 487 hormone receptor-like in 46, isoform A [Drosophila melanogaster]
GI:386767645 RefSeq XP_002089912.1 487 GE21721 [Drosophila yakuba]
GI:28573924 RefSeq XP_002089912.1 487 GE21721 [Drosophila yakuba]
GI:28573924 RefSeq NP_001246236.1 487 hormone receptor-like in 46, isoform F [Drosophila melanogaster]

Related Sequences to LMP008975 proteins

Reference Database Accession Length Protein Name
GI:442623145 GenBank AAA28461.1 487 DHR3 [Drosophila melanogaster]
GI:386767647 GenBank AAA28461.1 487 DHR3 [Drosophila melanogaster]
GI:161076500 GenBank AAM11076.1 444 GH21112p [Drosophila melanogaster]
GI:320543744 GenBank EDV58140.1 702 GG25225 [Drosophila erecta]
GI:28573920 GenBank EDV58140.1 702 GG25225 [Drosophila erecta]
GI:386767645 GenBank EDW32337.1 487 GL10487 [Drosophila persimilis]
GI:320543744 GenBank EDW47221.1 845 GM20545 [Drosophila sechellia]
GI:28573920 GenBank EDW47221.1 845 GM20545 [Drosophila sechellia]
GI:386767645 GenBank ABN49269.2 487 IP15960p [Drosophila melanogaster]
GI:28573924 GenBank ABN49269.2 487 IP15960p [Drosophila melanogaster]
GI:161076500 GenBank ACL86130.1 444 Hr46-PB, partial [synthetic construct]
GI:161076500 GenBank ACL88801.1 444 Hr46-PB [synthetic construct]
GI:386767647 GenBank AEY64286.1 487 FI17818p1 [Drosophila melanogaster]
GI:442623145 GenBank AEY64286.1 487 FI17818p1 [Drosophila melanogaster]
GI:442623145 gnl FlyBase 487 hormone receptor-like in 46, isoform A [Drosophila melanogaster]
GI:386767647 gnl FlyBase 487 hormone receptor-like in 46, isoform A [Drosophila melanogaster]
GI:161076500 gnl FlyBase 694 hormone receptor-like in 46, isoform C [Drosophila melanogaster]
GI:320543744 gnl FlyBase 694 hormone receptor-like in 46, isoform C [Drosophila melanogaster]
GI:386767645 gnl WGS:AADE 487 GA17350 [Drosophila pseudoobscura pseudoobscura]
GI:28573924 gnl WGS:AADE 487 GA17350 [Drosophila pseudoobscura pseudoobscura]
GI:28573920 gnl FlyBase 874 hormone receptor-like in 46, isoform E [Drosophila melanogaster]
GI:386767645 gnl FlyBase 529 hormone receptor-like in 46, isoform H [Drosophila melanogaster]
GI:28573924 gnl FlyBase 529 hormone receptor-like in 46, isoform H [Drosophila melanogaster]
GI:320543744 RefSeq NP_788301.1 694 hormone receptor-like in 46, isoform C [Drosophila melanogaster]
GI:161076500 RefSeq NP_788301.1 694 hormone receptor-like in 46, isoform C [Drosophila melanogaster]
GI:386767647 RefSeq NP_788303.1 487 hormone receptor-like in 46, isoform A [Drosophila melanogaster]
GI:442623145 RefSeq NP_788303.1 487 hormone receptor-like in 46, isoform A [Drosophila melanogaster]
GI:28573924 RefSeq XP_001360799.1 487 GA17350 [Drosophila pseudoobscura pseudoobscura]
GI:386767645 RefSeq XP_001360799.1 487 GA17350 [Drosophila pseudoobscura pseudoobscura]
GI:28573920 RefSeq XP_001969081.1 702 GG25225 [Drosophila erecta]
GI:320543744 RefSeq XP_001969081.1 702 GG25225 [Drosophila erecta]
GI:28573924 RefSeq XP_002016447.1 487 GL10487 [Drosophila persimilis]
GI:28573920 RefSeq XP_002033208.1 845 GM20545 [Drosophila sechellia]
GI:320543744 RefSeq XP_002033208.1 845 GM20545 [Drosophila sechellia]
GI:442623145 RefSeq XP_002089912.1 487 GE21721 [Drosophila yakuba]
GI:386767647 RefSeq XP_002089912.1 487 GE21721 [Drosophila yakuba]
GI:161076500 RefSeq NP_788302.2 874 hormone receptor-like in 46, isoform E [Drosophila melanogaster]
GI:28573920 RefSeq NP_788302.2 874 hormone receptor-like in 46, isoform E [Drosophila melanogaster]
GI:386767645 RefSeq NP_001260854.1 529 hormone receptor-like in 46, isoform H [Drosophila melanogaster]
GI:28573924 RefSeq NP_001260854.1 529 hormone receptor-like in 46, isoform H [Drosophila melanogaster]
GI:386767647 SwissProt P31396.1 487 RecName: Full=Probable nuclear hormone receptor HR3; Short=dHR3; AltName: Full=Nuclear receptor subfamily 1 group F member 4 [Drosophila melanogaster]
GI:442623145 SwissProt P31396.1 487 RecName: Full=Probable nuclear hormone receptor HR3; Short=dHR3; AltName: Full=Nuclear receptor subfamily 1 group F member 4 [Drosophila melanogaster]