Gene/Proteome Database (LMPD)

LMPD ID
LMP009026
Gene ID
32437
Species
Drosophila melanogaster (Drosophila)
Gene Name
Lipid storage droplet-2
Gene Symbol
Lsd-2
Synonyms
145098_at; CG9057; Dmel\CG9057; DmPLIN2; LSD-2; Lsd2; LSD2; plin2; PLIN2
Chromosome
X
Map Location
13A8-13A9

Proteins

lipid storage droplet-2, isoform A
Refseq ID NP_572996
Protein GI 18859967
UniProt ID Q9VXY7
mRNA ID NM_132768
Length 352
RefSeq Status REVIEWED
MASAEQKHATGNGTTGNGTAMNDVDQPKDAKDLLPHLESLERIIKLPVVNAAWDKSQDVYGKVKGKNRVFEWALTAAEDCVTRAVTTAAPFVTKLDRPIAYVDQTLVKGIDKLEVKAPIIKDTPQEIYNQAKSKVIDVVQPHLERVVKFKAAGQQKAASLKDLAWQKANEVLATQYGSLAVNGVDTTTALAERLLEYYFPKCESDVEEDNDDKQNAVVQNGKSSENDMPVPASEDPVLHTVQTVGRLSNKISRRVYRNVSRQIKQVQKGNINDYLSSLIAALKLHQYINFINSSMGTNVEQSGGSSSDACSPFGTTTSTTTTTTTSSTSNNKPVVALPHVAKSKRAPAVSSQ
lipid storage droplet-2, isoform B
Refseq ID NP_001036276
Protein GI 116007162
UniProt ID Q0KHS7
mRNA ID NM_001042811
Length 335
RefSeq Status REVIEWED
MASAEQKHATGNGTTGNGTAMNDVDQPKDAKDLLPHLESLERIIKLPVVNAAWDKSQDVYGKVKGKNRVFEWALTAAEDCVTRAVTTAAPFVTKLDRPIAYVDQTLVKGIDKLEVKAPIIKDTPQEIYNQAKSKVIDVVQPHLERVVKFKAAGQQKAASLKDLAWQKANEVLATQYGSLAVNGVDTTTALAERLLEYYFPKCESDVEEDNVPVPASEDPVLHTVQTVGRLSNKISRRVYRNVSRQIKQVQKGNINDYLSSLIAALKLHQYINFINSSMGTNVEQSGGSSSDACSPFGTTTSTTTTTTTSSTSNNKPVVALPHVAKSKRAPAVSSQ
lipid storage droplet-2, isoform D
Refseq ID NP_001036277
Protein GI 665391412
UniProt ID Q0KHS6
mRNA ID NM_001042812
Length 318
RefSeq Status REVIEWED
MASAEQKHATGNGTTGNGTAMNDVDQPKDAKDLLPHLESLERIIKLPVVNAAWDKSQDVYGKVKGKNRVFEWALTAAEDCVTRAVTTAAPFVTKLDRPIAYVDQTLVKGIDKLEVKAPIIKDTPQEIYNQAKSKVIDVVQPHLERVVKFKAAGQQKAASLKDLAWQKANEVLATQYGSLAVNGVDTTTALAERLLEYYFPKCESDVEEDNVIIVGESYDRDHDQEIDDRFLVAASTVFLSMSLKIITEIVEYVRRNPEIVGIIDRELNKFMCQFPPARIQSYTQYRQLDGYPIRSRVASIEMSPDRSSRSRRATSTTI
lipid storage droplet-2, isoform E
Refseq ID NP_001285261
Protein GI 665391414
UniProt ID X2JKC1
mRNA ID NM_001298332
Length 335
RefSeq Status REVIEWED
MASAEQKHATGNGTTGNGTAMNDVDQPKDAKDLLPHLESLERIIKLPVVNAAWDKSQDVYGKVKGKNRVFEWALTAAEDCVTRAVTTAAPFVTKLDRPIAYVDQTLVKGIDKLEVKAPIIKDTPQEIYNQAKSKVIDVVQPHLERVVKFKAAGQQKAASLKDLAWQKANEVLATQYGSLAVNGVDTTTALAERLLEYYFPKCESDVEEDNDDKQNAVVQNGKSSENDIIIVGESYDRDHDQEIDDRFLVAASTVFLSMSLKIITEIVEYVRRNPEIVGIIDRELNKFMCQFPPARIQSYTQYRQLDGYPIRSRVASIEMSPDRSSRSRRATSTTI
lipid storage droplet-2, isoform F
Refseq ID NP_001285262
Protein GI 665391416
UniProt ID X2JKC1
mRNA ID NM_001298333
Length 335
RefSeq Status REVIEWED
Protein sequence is identical to GI:665391414 (mRNA isoform)

Gene Information

Entrez Gene ID
32437
Gene Name
Lipid storage droplet-2
Gene Symbol
Lsd-2
Species
Drosophila melanogaster

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IEA:UniProtKB-KW C cytoplasm
GO:0005811 IDA:UniProtKB C lipid particle
GO:0005875 IDA:FlyBase C microtubule associated complex
GO:0007476 IMP:FlyBase P imaginal disc-derived wing morphogenesis
GO:0006629 IMP:FlyBase P lipid metabolic process
GO:0031887 IMP:FlyBase P lipid particle transport along microtubule
GO:0019915 IEP:UniProtKB P lipid storage
GO:0006869 IEP:UniProtKB P lipid transport
GO:0050995 IMP:FlyBase P negative regulation of lipid catabolic process
GO:0051049 IMP:FlyBase P regulation of transport
GO:0030730 IMP:FlyBase P sequestering of triglyceride

Domain Information

InterPro Annotations

Accession Description
IPR004279 Perilipin

UniProt Annotations

Entry Information

Gene Name
Lipid storage droplet-2
Protein Entry
Q0KHS7_DROME
UniProt ID
X2JKC1
Species
Drosophila

Comments

Comment Type Description
Developmental Stage Expressed both maternally and zygotically. Expressed throughout development with highest zygotic expression in third instar larva and pupae. {ECO:0000269|PubMed:12676093, ECO:0000269|PubMed:14550535}.
Function Essential for embryogenesis. Required for normal deposition of neutral lipids in the oocyte. {ECO:0000269|PubMed:12676093, ECO:0000269|PubMed:14550535}.
Similarity Belongs to the perilipin family. {ECO:0000305}.
Subcellular Location Cytoplasm. Lipid droplet. Note=Cytoplasm and on surface of neutral lipid storage droplets in oocytes. Colocalizes with Lsd-1 to the droplet surface in cells of fat bodies.
Tissue Specificity Ubiquitous expression in early embryos. At stage 5 expression is restricted to the pole cells. At stage 11 expression is seen in the amnioserosa, refined to the fat body and midgut by stage 14. Also seen in the hindgut by the end of embryogenesis. Expression is seen in larval fat body (at protein level). {ECO:0000269|PubMed:12676093, ECO:0000269|PubMed:14550535}.

Identical and Related Proteins

Unique RefSeq proteins for LMP009026 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
18859967 RefSeq NP_572996 352 lipid storage droplet-2, isoform A
116007162 RefSeq NP_001036276 335 lipid storage droplet-2, isoform B
665391412 RefSeq NP_001036277 318 lipid storage droplet-2, isoform D
665391414 RefSeq NP_001285261 335 lipid storage droplet-2, isoform E

Identical Sequences to LMP009026 proteins

Reference Database Accession Length Protein Name
GI:18859967 GenBank AAL25281.1 352 GH06230p [Drosophila melanogaster]
GI:18859967 GenBank ACL89947.1 352 Lsd-2-PA [synthetic construct]
GI:18859967 GenBank ACL92567.1 352 Lsd-2-PA, partial [synthetic construct]
GI:18859967 gnl FlyBase 352 lipid storage droplet-2, isoform A [Drosophila melanogaster]
GI:116007162 gnl FlyBase 335 lipid storage droplet-2, isoform B [Drosophila melanogaster]
GI:665391412 gnl FlyBase 318 lipid storage droplet-2, isoform D [Drosophila melanogaster]
GI:665391414 gnl FlyBase 335 lipid storage droplet-2, isoform E [Drosophila melanogaster]
GI:665391414 gnl FlyBase 335 lipid storage droplet-2, isoform F [Drosophila melanogaster]
GI:665391414 RefSeq NP_001285262.1 335 lipid storage droplet-2, isoform F [Drosophila melanogaster]
GI:18859967 SwissProt Q9VXY7.1 352 RecName: Full=Lipid storage droplets surface-binding protein 2; Short=Lsd2 [Drosophila melanogaster]

Related Sequences to LMP009026 proteins

Reference Database Accession Length Protein Name
GI:116007162 GenBank AAL25281.1 352 GH06230p [Drosophila melanogaster]
GI:18859967 GenBank EDW51071.1 336 GM12009 [Drosophila sechellia]
GI:18859967 GenBank EDX17939.1 336 GD15823 [Drosophila simulans]
GI:665391414 GenBank ACL89947.1 352 Lsd-2-PA [synthetic construct]
GI:116007162 GenBank ACL89947.1 352 Lsd-2-PA [synthetic construct]
GI:665391414 GenBank ACL92567.1 352 Lsd-2-PA, partial [synthetic construct]
GI:116007162 GenBank ACL92567.1 352 Lsd-2-PA, partial [synthetic construct]
GI:116007162 gnl FlyBase 352 lipid storage droplet-2, isoform A [Drosophila melanogaster]
GI:18859967 gnl FlyBase 335 lipid storage droplet-2, isoform B [Drosophila melanogaster]
GI:665391414 gnl FlyBase 318 lipid storage droplet-2, isoform D [Drosophila melanogaster]
GI:665391412 gnl FlyBase 335 lipid storage droplet-2, isoform E [Drosophila melanogaster]
GI:665391412 gnl FlyBase 335 lipid storage droplet-2, isoform F [Drosophila melanogaster]
GI:116007162 RefSeq NP_572996.1 352 lipid storage droplet-2, isoform A [Drosophila melanogaster]
GI:18859967 RefSeq NP_001036276.1 335 lipid storage droplet-2, isoform B [Drosophila melanogaster]
GI:665391412 RefSeq NP_001036276.1 335 lipid storage droplet-2, isoform B [Drosophila melanogaster]
GI:18859967 RefSeq XP_002043802.1 336 GM12009 [Drosophila sechellia]
GI:18859967 RefSeq XP_002106966.1 336 GD15823 [Drosophila simulans]
GI:665391414 RefSeq XP_005188652.1 307 PREDICTED: lipid storage droplets surface-binding protein 2-like isoform X2 [Musca domestica]
GI:665391412 RefSeq XP_005188652.1 307 PREDICTED: lipid storage droplets surface-binding protein 2-like isoform X2 [Musca domestica]
GI:665391414 RefSeq NP_001036277.2 318 lipid storage droplet-2, isoform D [Drosophila melanogaster]
GI:665391412 RefSeq NP_001285261.1 335 lipid storage droplet-2, isoform E [Drosophila melanogaster]
GI:665391412 RefSeq NP_001285262.1 335 lipid storage droplet-2, isoform F [Drosophila melanogaster]
GI:116007162 SwissProt Q9VXY7.1 352 RecName: Full=Lipid storage droplets surface-binding protein 2; Short=Lsd2 [Drosophila melanogaster]
GI:665391414 SwissProt Q9VXY7.1 352 RecName: Full=Lipid storage droplets surface-binding protein 2; Short=Lsd2 [Drosophila melanogaster]