Gene/Proteome Database (LMPD)

LMPD ID
LMP009036
Gene ID
43838
Species
Drosophila melanogaster (Drosophila)
Gene Name
metabotropic Glutamate Receptor
Gene Symbol
mGluR
Synonyms
CAA67993.1_Dr; CG11144; Dmel\CG11144; DmGlu-A; DmGlu-RA; DmGluA; DmGluAR; DmGluR; dmGluRA; DmGluRA; DmGluR[[A]]; DmGlu[[A]]R; Glu-RA; GluR; mGLuR; mGluRA
Chromosome
4
Map Location
102F1-102F3

Proteins

metabotropic glutamate receptor, isoform A
Refseq ID NP_524639
Protein GI 24638732
UniProt ID P91685
mRNA ID NM_079900
Length 976
RefSeq Status REVIEWED
MKQKNNNGTILVVVMVLSWSRVVDLKSPSNTHTQDSVSVSLPGDIILGGLFPVHEKGEGAPCGPKVYNRGVQRLEAMLYAIDRVNNDPNILPGITIGVHILDTCSRDTYALNQSLQFVRASLNNLDTSGYECADGSSPQLRKNASSGPVFGVIGGSYSSVSLQVANLLRLFHIPQVSPASTAKTLSDKTRFDLFARTVPPDTFQSVALVDILKNFNWSYVSTIHSEGSYGEYGIEALHKEATERNVCIAVAEKVPSAADDKVFDSIISKLQKKPNARGVVLFTRAEDARRILQAAKRANLSQPFHWIASDGWGKQQKLLEGLEDIAEGAITVELQSEIIADFDRYMMQLTPETNQRNPWFAEYWEDTFNCVLTSLSVKPDTSNSANSTDNKIGVKAKTECDDSYRLSEKVGYEQESKTQFVVDAVYAFAYALHNLHNDRCNTQSDQTTETRKHLQSESVWYRKISTDTKSQACPDMANYDGKEFYNNYLLNVSFIDLAGSEVKFDRQGDGLARYDILNYQRQENSSGYQYKVIGKWFNGLQLNSETVVWNKETEQPTSACSLPCEVGMIKKQQGDTCCWICDSCESFEYVYDEFTCKDCGPGLWPYADKLSCYALDIQYMKWNSLFALIPMAIAIFGIALTSIVIVLFAKNHDTPLVRASGRELSYTLLFGILVCYCNTFALIAKPTIGSCVLQRFGIGVGFSIIYSALLTKTNRISRIFHSASKSAQRLKYISPQSQVVITTSLIAIQVLITMIWMVVEPPGTRFYYPDRREVILKCKIQDMSFLFSQLYNMILITICTIYAIKTRKIPENFNESKFIGFTMYTTCIIWLAFVPIYFGTGNSYEVQTTTLCISISLSASVALVCLYSPKVYILVFHPDKNVRKLTMNSTVYRRSAAAVAQGAPTSSGYSRTHAPGTSALTGGAVGTNASSSTLPTQNSPHLDEASAQTNVAHKTNGEFLPEVGERVEPICHIVNK
metabotropic glutamate receptor, isoform B
Refseq ID NP_001259076
Protein GI 442614497
UniProt ID P91685
mRNA ID NM_001272147
Length 976
RefSeq Status REVIEWED
MKQKNNNGTILVVVMVLSWSRVVDLKSPSNTHTQDSVSVSLPGDIILGGLFPVHEKGEGAPCGPKVYNRGVQRLEAMLYAIDRVNNDPNILPGITIGVHILDTCSRDTYALNQSLQFVRASLNNLDTSGYECADGSSPQLRKNASSGPVFGVIGGSYSSVSLQVANLLRLFHIPQVSPASTAKTLSDKTRFDLFARTVPPDTFQSVALVDILKNFNWSYVSTIHSEGSYGEYGIEALHKEATERNVCIAVAEKVPSAADDKVFDSIISKLQKKPNARGVVLFTRAEDARRILQAAKRANLSQPFHWIASDGWGKQQKLLEGLEDIAEGAITVELQSEIIADFDRYMMQLTPETNQRNPWFAEYWEDTFNCVLTSLSVKPDTSNSANSTDNKIGVKAKTECDDSYRLSEKVGYEQESKTQFVVDAVYAFAYALHNLHNDRCNTQSDQTTETRKHLQSESVWYRKISTDTKSQACPDMANYDGKEFYNNYLLNVSFIDLAGSEVKFDRQGDGLARYDILNYQRQENSSGYQYKVIGKWFNGLQLNSETVVWNKETEQPTSACSLPCEVGMIKKQQGDTCCWICDSCESFEYVYDEFTCKDCGPGLWPYADKLSCYALDIQYMKWNSLFALIPMAIAIFGIALTSIVIVLFAKNHDTPLVRASGRELSYTLLFGILVCYCNTFALIAKPTIGSCVLQRFGIGVGFSIIYSALLTKTNRISRIFHSASKSAQRLKYISPQSQVVITTSLIAIQVLITMIWMVVEPPGTRFYYPDRREVILKCKIQDMSFLFSQLYNMILITICTIYAIKTRKIPENFNESKFIGFTMYTTCIIWLAFVPIYFGTGNSYEVQTTTLCISISLSASVALVCLYSPKVYILVFHPDKNVRKLTMNSTVYRRSAAAVAQGAPTSSGYSRTHAPGTSALTGGAVGTNASSSTLPTQNSPHLDEASAQTNVAHKTNGEFLPEVGERVEPICHIVNK
metabotropic glutamate receptor, isoform C
Refseq ID NP_001259077
Protein GI 442614499
UniProt ID C5WLT4
mRNA ID NM_001272148
Length 533
RefSeq Status REVIEWED
MKQKNNNGTILVVVMVLSWSRVVDLKSPSNTHTQDSVSVSLPGDIILGGLFPVHEKGEGAPCGPKVYNRGVQRLEAMLYAIDRVNNDPNILPGITIGVHILDTCSRDTYALNQSLQFVRASLNNLDTSGYECADGSSPQLRKNASSGPVFGVIGGSYSSVSLQVANLLRLFHIPQVSPASTAKTLSDKTRFDLFARTVPPDTFQSVALVDILKNFNWSYVSTIHSEGSYGEYGIEALHKEATERNVCIAVAEKVPSAADDKVFDSIISKLQKKPNARGVVLFTRAEDARRILQAAKRANLSQPFHWIASDGWGKQQKLLEGLEDIAEGAITVELQSEIIADFDRYMMQLTPETNQRNPWFAEYWEDTFNCVLTSLSVKPDTSNSANSTDNKIGVKAKTECDDSYRLSEKVGYEQESKTQFVVDAVYAFAYALHNLHNDRCNTQSDQTTETRKHLQSESVWYRKISTDTKSQACPDMANYDGKEFYNNYLLNVSFIDLAGSEVKFDRQGDGLARYDILNYQRQENSSGYQYKVP
metabotropic glutamate receptor, isoform D
Refseq ID NP_001284718
Protein GI 665388817
UniProt ID X2JBI2
mRNA ID NM_001297789
Length 308
RefSeq Status REVIEWED
MKQKNNNGTILVVVMVLSWSRVVDLKSPSNTHTQDSVSVSLPGDIILGGLFPVHEKGEGAPCGPKVYNRGVQRLEAMLYAIDRVNNDPNILPGITIGVHILDTCSRDTYALNQSLQFVRASLNNLDTSGYECADGSSPQLRKNASSGPVFGVIGGSYSSVSLQVANLLRLFHIPQVSPASTAKTLSDKTRFDLFARTVPPDTFQSVALVDILKNFNWSYVSTIHSEGSYDTNRSQRHNLLWMPSTHLPMHFIICIMIVATHKATKRLRQGSTYKANLCGIEKFRLILSPKRVLTWLIMTERSFTTITF

Gene Information

Entrez Gene ID
43838
Gene Name
metabotropic Glutamate Receptor
Gene Symbol
mGluR
Species
Drosophila melanogaster

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016021 ISS:FlyBase C integral component of membrane
GO:0005887 IDA:FlyBase C integral component of plasma membrane
GO:0045121 IDA:FlyBase C membrane raft
GO:0005886 IDA:FlyBase C plasma membrane
GO:0042734 IBA:RefGenome C presynaptic membrane
GO:0004930 ISS:FlyBase F G-protein coupled receptor activity
GO:0015485 IDA:FlyBase F cholesterol binding
GO:0016595 IDA:FlyBase F glutamate binding
GO:0008066 ISS:FlyBase F glutamate receptor activity
GO:0001641 IDA:FlyBase F group II metabotropic glutamate receptor activity
GO:0001642 IBA:RefGenome F group III metabotropic glutamate receptor activity
GO:0007216 IDA:FlyBase P G-protein coupled glutamate receptor signaling pathway
GO:0007196 IBA:RefGenome P adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway
GO:0007528 IMP:FlyBase P neuromuscular junction development
GO:0051966 IMP:FlyBase P regulation of synaptic transmission, glutamatergic

KEGG Pathway Links

KEGG Pathway ID Description
dme04080 Neuroactive ligand-receptor interaction
ko04080 Neuroactive ligand-receptor interaction

REACTOME Pathway Links

REACTOME Pathway ID Description
6226599 Class C/3 (Metabotropic glutamate/pheromone receptors)
6226617 G alpha (i) signalling events
6226200 GPCR downstream signaling
6226523 GPCR ligand binding
6225975 Signal Transduction
6225984 Signaling by GPCR

Domain Information

InterPro Annotations

Accession Description
IPR001828 ANF_lig-bd_rcpt
IPR000337 GPCR_3
IPR011500 GPCR_3_9-Cys_dom
IPR017978 GPCR_3_C
IPR017979 GPCR_3_CS
IPR000162 GPCR_3_mtglu_rcpt
IPR028082 Peripla_BP_I

UniProt Annotations

Entry Information

Gene Name
metabotropic Glutamate Receptor
Protein Entry
GRM_DROME
UniProt ID
X2JBI2
Species
Drosophila

Comments

Comment Type Description
Developmental Stage Expressed in the CNS of the late embryo. {ECO:0000269|PubMed:8824309}.
Function G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. {ECO:0000269|PubMed:10821630, ECO:0000269|PubMed:8824309}.
Similarity Belongs to the G-protein coupled receptor 3 family. {ECO:0000305}.
Subcellular Location Cell membrane {ECO:0000269|PubMed:8824309}; Multi-pass membrane protein {ECO:0000269|PubMed:8824309}.
Tissue Specificity Expressed in the neurons of the larval CNS from the beginning of the first until the third instar. Expression in the third-instar larval CNS is restricted to a discrete number of somas and projections in the brain lobes and in the ventral ganglion. In the ventral nerve cord, expression is detected both in somas and projections. Expressed in the antennal lobes, the optic lobes, the central complex and the median bundle in the adult CNS. {ECO:0000269|PubMed:11536189}.

Identical and Related Proteins

Unique RefSeq proteins for LMP009036 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
24638732 RefSeq NP_524639 976 metabotropic glutamate receptor, isoform A
442614497 RefSeq NP_001259076 976 metabotropic glutamate receptor, isoform B
442614499 RefSeq NP_001259077 533 metabotropic glutamate receptor, isoform C
665388817 RefSeq NP_001284718 308 metabotropic glutamate receptor, isoform D

Identical Sequences to LMP009036 proteins

Reference Database Accession Length Protein Name
GI:442614499 GenBank ACT09396.1 533 IP03318p [Drosophila melanogaster]
GI:442614497 gnl FlyBase 976 metabotropic glutamate receptor, isoform A [Drosophila melanogaster]
GI:24638732 gnl FlyBase 976 metabotropic glutamate receptor, isoform A [Drosophila melanogaster]
GI:24638732 gnl FlyBase 976 metabotropic glutamate receptor, isoform B [Drosophila melanogaster]
GI:442614497 gnl FlyBase 976 metabotropic glutamate receptor, isoform B [Drosophila melanogaster]
GI:442614499 gnl FlyBase 533 metabotropic glutamate receptor, isoform C [Drosophila melanogaster]
GI:665388817 gnl FlyBase 308 metabotropic glutamate receptor, isoform D [Drosophila melanogaster]
GI:442614497 RefSeq NP_524639.2 976 metabotropic glutamate receptor, isoform A [Drosophila melanogaster]
GI:24638732 RefSeq NP_001259076.1 976 metabotropic glutamate receptor, isoform B [Drosophila melanogaster]
GI:24638732 SwissProt P91685.2 976 RecName: Full=Metabotropic glutamate receptor; Short=DmGluRA; Flags: Precursor [Drosophila melanogaster]
GI:442614497 SwissProt P91685.2 976 RecName: Full=Metabotropic glutamate receptor; Short=DmGluRA; Flags: Precursor [Drosophila melanogaster]

Related Sequences to LMP009036 proteins

Reference Database Accession Length Protein Name
GI:24638732 EMBL CAA67993.1 976 metabotropic glutamate receptor [Drosophila melanogaster]
GI:442614497 EMBL CAA67993.1 976 metabotropic glutamate receptor [Drosophila melanogaster]
GI:442614499 EMBL CAA67993.1 976 metabotropic glutamate receptor [Drosophila melanogaster]
GI:665388817 EMBL CAA67993.1 976 metabotropic glutamate receptor [Drosophila melanogaster]
GI:24638732 GenBank EDV45220.1 975 GG16401 [Drosophila erecta]
GI:442614497 GenBank EDV45220.1 975 GG16401 [Drosophila erecta]
GI:442614497 GenBank EDW25265.1 950 GL17542 [Drosophila persimilis]
GI:24638732 GenBank EDW25265.1 950 GL17542 [Drosophila persimilis]
GI:442614497 GenBank EDW99339.1 976 GE14562 [Drosophila yakuba]
GI:24638732 GenBank EDW99339.1 976 GE14562 [Drosophila yakuba]
GI:442614499 gnl FlyBase 976 metabotropic glutamate receptor, isoform A [Drosophila melanogaster]
GI:665388817 gnl FlyBase 976 metabotropic glutamate receptor, isoform A [Drosophila melanogaster]
GI:442614499 gnl FlyBase 976 metabotropic glutamate receptor, isoform B [Drosophila melanogaster]
GI:665388817 gnl FlyBase 976 metabotropic glutamate receptor, isoform B [Drosophila melanogaster]
GI:665388817 RefSeq NP_524639.2 976 metabotropic glutamate receptor, isoform A [Drosophila melanogaster]
GI:442614499 RefSeq NP_524639.2 976 metabotropic glutamate receptor, isoform A [Drosophila melanogaster]
GI:24638732 RefSeq XP_001982701.1 975 GG16401 [Drosophila erecta]
GI:442614497 RefSeq XP_001982701.1 975 GG16401 [Drosophila erecta]
GI:442614497 RefSeq XP_002099627.1 976 GE14562 [Drosophila yakuba]
GI:24638732 RefSeq XP_002099627.1 976 GE14562 [Drosophila yakuba]
GI:665388817 RefSeq NP_001259076.1 976 metabotropic glutamate receptor, isoform B [Drosophila melanogaster]
GI:442614499 RefSeq NP_001259076.1 976 metabotropic glutamate receptor, isoform B [Drosophila melanogaster]
GI:442614499 SwissProt P91685.2 976 RecName: Full=Metabotropic glutamate receptor; Short=DmGluRA; Flags: Precursor [Drosophila melanogaster]
GI:665388817 SwissProt P91685.2 976 RecName: Full=Metabotropic glutamate receptor; Short=DmGluRA; Flags: Precursor [Drosophila melanogaster]