Gene/Proteome Database (LMPD)

LMPD ID
LMP009042
Gene ID
37884
Species
Drosophila melanogaster (Drosophila)
Gene Name
CG3376 gene product from transcript CG3376-RB
Gene Symbol
CG3376
Synonyms
aSMase; Dmel\CG3376
Chromosome
2R
Map Location
60C4-60C4

Proteins

CG3376, isoform A
Refseq ID NP_611904
Protein GI 20130351
UniProt ID Q9W188
mRNA ID NM_138060
Length 735
RefSeq Status REVIEWED
MTQQQPPWPSPISSSSSNPRGKCWLILVLMAVLPLVADVGALPFLFTHIKPQINWTQPEMESWVIEEQPRSIEPHLEPVLHPNRTHRALSSDSTDAEFLQRLVSIRHNQTASSRMLWYDVAGGDGLVYPPFVDKALKLLNLKQVAFEIENSVMSKVTCTACRAGAGMLQHQIQSGKTDAELIRMITDYCTNLNIQSARVCQGVAQLFGSELIYVLKRVNLSPDELCSFVIGDGCADVYNPYHEWEVIFPPVPKPPRLPDLPIPMEAAPFFKVLHISDTHYDPHYAEGSNADCNEPLCCRLSSGRPATPNAAAGKWGDYRKCDTPKRTVDHMLSHIAETHKDIDYILWTGDLPPHDVWNQTKEENLAIIKDTVKQMVEMFPGVPIFPALGNHESAPVNSFPPPYVNQVDISISWLYDELDIQWRRWLPQSVTHTVRRGAFYSVLVRPGFRIISLNMNYCNNKNWWLLLNSTDPATELQWFIYELQSAEFSNEKVHVIGHIPPGHSDCLKVWSRNFYKIISRYESTVTAQFYGHTHYDEFEMFYDPHDLNHPNGIAYIGPSVSPYYDLNPGYRIYYVDGDHDATTRLVIDHESWIMNLKEANLYGYPIWYKLYTARAAYNMKALRPSDWNNLLNELTNNQELFELYYKYYWKNSPARPTCDAECKKRLICDCRSGRSHDRKHFCAEVESKIDEESSKSWKSWFYKGLTNSAEDRTEEPAPTTDGYGPFDVVIVNVGG
CG3376, isoform B
Refseq ID NP_726435
Protein GI 24762598
UniProt ID Q8MLP3
mRNA ID NM_166665
Length 708
RefSeq Status REVIEWED
MTQQQPPWPSPISSSSSNPRGKCWLILVLMAVLPLVADVGALPFLFTHIKPQINWTQPEMESWVIEEQPRSIEPHLEPVLHPNRTHRALSSDSTDAEFLQRLVSIRHNQTASSRMLWYDVAGGDGLVYPPFVDKALKLLNLKQVAFEIENSVMSKVTCTACRAGAGMLQHQIQSGKTDAELIRMITDYCTNLNIQSARVCQGVAQLFGSELIYVLKRVNLSPDELCSFVIGDGCADVYNPYHEWEVIFPPVPKPPRLPDLPIPMEAAPFFKVLHISDTHYDPHYAEGSNADCNEPLCCRLSSGRPATPNAAAGKWGDYRKCDTPKRTVDHMLSHIAETHKDIDYILWTGDLPPHDVWNQTKEENLAIIKDTVKQMVEMFPGVPIFPALGNHESAPVNSFPPPYVNQVDISISWLYDELDIQWRRWLPQSVTHTVRRGAFYSVLVRPGFRIISLNMNYCNNKNWWLLLNSTDPATELQWFIYELQSAEFSNEKVHVIGHIPPGHSDCLKVWSRNFYKIISRYESTVTAQFYGHTHYDEFEMFYDPHDLNHPNGIAYIGPSVSPYYDLNPGYRIYYVDGDHDATTRLVIDHESWIMNLKEANLYGYPIWYKLYTARAAYNMKALRPSDWNNLLNELTNNQELFELYYKYYWKNSPARPTCDAECKKRLICDCRSGRSHDRKHFCAEVESKIDEESSKSWKSWFYKGLTNS
CG3376, isoform C
Refseq ID NP_001246491
Protein GI 386768564
UniProt ID D6W4U0
mRNA ID NM_001259562
Length 764
RefSeq Status REVIEWED
MKPVSQSQAAYSSPHLVEPGVAKSTSPHIMTQQQPPWPSPISSSSSNPRGKCWLILVLMAVLPLVADVGALPFLFTHIKPQINWTQPEMESWVIEEQPRSIEPHLEPVLHPNRTHRALSSDSTDAEFLQRLVSIRHNQTASSRMLWYDVAGGDGLVYPPFVDKALKLLNLKQVAFEIENSVMSKVTCTACRAGAGMLQHQIQSGKTDAELIRMITDYCTNLNIQSARVCQGVAQLFGSELIYVLKRVNLSPDELCSFVIGDGCADVYNPYHEWEVIFPPVPKPPRLPDLPIPMEAAPFFKVLHISDTHYDPHYAEGSNADCNEPLCCRLSSGRPATPNAAAGKWGDYRKCDTPKRTVDHMLSHIAETHKDIDYILWTGDLPPHDVWNQTKEENLAIIKDTVKQMVEMFPGVPIFPALGNHESAPVNSFPPPYVNQVDISISWLYDELDIQWRRWLPQSVTHTVRRGAFYSVLVRPGFRIISLNMNYCNNKNWWLLLNSTDPATELQWFIYELQSAEFSNEKVHVIGHIPPGHSDCLKVWSRNFYKIISRYESTVTAQFYGHTHYDEFEMFYDPHDLNHPNGIAYIGPSVSPYYDLNPGYRIYYVDGDHDATTRLVIDHESWIMNLKEANLYGYPIWYKLYTARAAYNMKALRPSDWNNLLNELTNNQELFELYYKYYWKNSPARPTCDAECKKRLICDCRSGRSHDRKHFCAEVESKIDEESSKSWKSWFYKGLTNSAEDRTEEPAPTTDGYGPFDVVIVNVGG
CG3376, isoform D
Refseq ID NP_001286833
Protein GI 665403419
UniProt ID Q8MLP3
mRNA ID NM_001299904
Length 726
RefSeq Status REVIEWED
MTQQQPPWPSPISSSSSNPRGKCWLILVLMAVLPLVADVGALPFLFTHIKPQINWTQPEMESWVIEEQPRSIEPHLEPVLHPNRTHRALSSDSTDAEFLQRLVSIRHNQTASSRMLWYDVAGGDGLVYPPFVDKALKLLNLKQVAFEIENSVMSKVTCTACRAGAGMLQHQIQSGKTDAELIRMITDYCTNLNIQSARVCQGVAQLFGSELIYVLKRVNLSPDELCSFVIGDGCADVYNPYHEWEVIFPPVPKPPRLPDLPIPMEAAPFFKVLHISDTHYDPHYAEGSNADCNEPLCCRLSSGRPATPNAAAGKWGDYRKCDTPKRTVDHMLSHIAETHKDIDYILWTGDLPPHDVWNQTKEENLAIIKDTVKQMVEMFPGVPIFPALGNHESAPVNSFPPPYVNQVDISISWLYDELDIQWRRWLPQSVTHTVRRGAFYSVLVRPGFRIISLNMNYCNNKNWWLLLNSTDPATELQWFIYELQSAEFSNEKVHVIGHIPPGHSDCLKVWSRNFYKIISRYESTVTAQFYGHTHYDEFEMFYDPHDLNHPNGIAYIGPSVSPYYDLNPGYRIYYVDGDHDATTRLVIDHESWIMNLKEANLYGYPIWYKLYTARAAYNMKALRPSDWNNLLNELTNNQELFELYYKYYWKNSPARPTCDAECKKRLICDCRSGRSHDRKHFCAEVESKIDEESSKSWKSWFYKGLTNSYSLLSSITYLPKYLLGYR

Gene Information

Entrez Gene ID
37884
Gene Name
CG3376 gene product from transcript CG3376-RB
Gene Symbol
CG3376
Species
Drosophila melanogaster

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0004767 IEA:UniProtKB-EC F sphingomyelin phosphodiesterase activity
GO:0006685 IEA:InterPro P sphingomyelin catabolic process

KEGG Pathway Links

KEGG Pathway ID Description
dme04142 Lysosome
ko04142 Lysosome
dme01100 Metabolic pathways
dme00600 Sphingolipid metabolism
ko00600 Sphingolipid metabolism

Domain Information

InterPro Annotations

Accession Description
IPR004843 Calcineurin-like phosphoesterase domain, apaH type
IPR029052 Metallo-dependent phosphatase-like
IPR008139 Saposin B
IPR011001 Saposin-like
IPR011160 Sphingomyelin phosphodiesterase

UniProt Annotations

Entry Information

Gene Name
CG3376 gene product from transcript CG3376-RB
Protein Entry
D6W4U0_DROME
UniProt ID
Q9W188
Species
Drosophila

Comments

Comment Type Description
Catalytic Activity Sphingomyelin + H(2)O = N-acylsphingosine + phosphocholine. {ECO:0000256|PIRNR:PIRNR000948}.
Function Converts sphingomyelin to ceramide. {ECO:0000256|PIRNR:PIRNR000948}.
Similarity Belongs to the acid sphingomyelinase family. {ECO:0000256|PIRNR:PIRNR000948}.

Identical and Related Proteins

Unique RefSeq proteins for LMP009042 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
20130351 RefSeq NP_611904 735 CG3376, isoform A
24762598 RefSeq NP_726435 708 CG3376, isoform B
386768564 RefSeq NP_001246491 764 CG3376, isoform C
665403419 RefSeq NP_001286833 726 CG3376, isoform D

Identical Sequences to LMP009042 proteins

Reference Database Accession Length Protein Name
GI:20130351 GenBank AAL29014.1 735 LD42214p [Drosophila melanogaster]
GI:20130351 GenBank ACL90534.1 735 CG3376-PA [synthetic construct]
GI:386768564 GenBank ADI44148.1 764 MIP21179p [Drosophila melanogaster]
GI:20130351 gnl FlyBase 735 CG3376, isoform A [Drosophila melanogaster]
GI:24762598 gnl FlyBase 708 CG3376, isoform B [Drosophila melanogaster]
GI:386768564 gnl FlyBase 764 CG3376, isoform C [Drosophila melanogaster]
GI:665403419 gnl FlyBase 726 CG3376, isoform D [Drosophila melanogaster]

Related Sequences to LMP009042 proteins

Reference Database Accession Length Protein Name
GI:386768564 GenBank AAL29014.1 735 LD42214p [Drosophila melanogaster]
GI:24762598 GenBank AAL29014.1 735 LD42214p [Drosophila melanogaster]
GI:665403419 GenBank AAL29014.1 735 LD42214p [Drosophila melanogaster]
GI:20130351 GenBank EDV56977.1 728 GG22956 [Drosophila erecta]
GI:386768564 GenBank EDW92509.1 735 GE14393 [Drosophila yakuba]
GI:24762598 GenBank ACL90534.1 735 CG3376-PA [synthetic construct]
GI:665403419 GenBank ACL90534.1 735 CG3376-PA [synthetic construct]
GI:386768564 GenBank ACL90534.1 735 CG3376-PA [synthetic construct]
GI:24762598 GenBank ADI44148.1 764 MIP21179p [Drosophila melanogaster]
GI:20130351 GenBank ADI44148.1 764 MIP21179p [Drosophila melanogaster]
GI:665403419 gnl FlyBase 735 CG3376, isoform A [Drosophila melanogaster]
GI:386768564 gnl FlyBase 735 CG3376, isoform A [Drosophila melanogaster]
GI:24762598 gnl FlyBase 735 CG3376, isoform A [Drosophila melanogaster]
GI:20130351 gnl FlyBase 708 CG3376, isoform B [Drosophila melanogaster]
GI:665403419 gnl FlyBase 708 CG3376, isoform B [Drosophila melanogaster]
GI:20130351 gnl FlyBase 764 CG3376, isoform C [Drosophila melanogaster]
GI:665403419 RefSeq NP_611904.1 735 CG3376, isoform A [Drosophila melanogaster]
GI:386768564 RefSeq NP_611904.1 735 CG3376, isoform A [Drosophila melanogaster]
GI:24762598 RefSeq NP_611904.1 735 CG3376, isoform A [Drosophila melanogaster]
GI:665403419 RefSeq NP_726435.1 708 CG3376, isoform B [Drosophila melanogaster]
GI:20130351 RefSeq XP_001976577.1 728 GG22956 [Drosophila erecta]
GI:386768564 RefSeq XP_002092797.1 735 GE14393 [Drosophila yakuba]
GI:24762598 RefSeq NP_001246491.1 764 CG3376, isoform C [Drosophila melanogaster]
GI:20130351 RefSeq NP_001246491.1 764 CG3376, isoform C [Drosophila melanogaster]