Gene/Proteome Database (LMPD)
LMPD ID
LMP009044
Gene ID
Species
Drosophila melanogaster (Drosophila)
Gene Name
muscarinic Acetylcholine Receptor, A-type
Gene Symbol
Synonyms
Acr60C; AcrC; CG4356; Dm-mAChR-A; Dm1; DM1; Dmel\CG4356; mAChR; mAChR A; mAChR-1; mAcR; mAcR-60C; mAcR60C
Alternate Names
A-type mAChR; CG4356-PA; CG4356-PB; mAChR-A-PA; mAChR-A-PB; muscarinic acetylcholine Receptor, A-type; muscarinic acetylcholine receptor; muscarinic acetylcholine receptor 60C; muscarinic receptor
Chromosome
2R
Map Location
60C7-60C7
Proteins
| muscarinic acetylcholine Receptor, A-type, isoform A | |
|---|---|
| Refseq ID | NP_726440 |
| Protein GI | 24762610 |
| UniProt ID | P16395 |
| mRNA ID | NM_166668 |
| Length | 788 |
| RefSeq Status | REVIEWED |
| MEPVMSLALAAHGPPSILEPLFKTVTTSTTTTTTTTTSTTTTTASPAGYSPGYPGTTLLTALFENLTSTAASGLYDPYSGMYGNQTNGTIGFETKGPRYSLASMVVMGFVAAILSTVTVAGNVMVMISFKIDKQLQTISNYFLFSLAIADFAIGAISMPLFAVTTILGYWPLGPIVCDTWLALDYLASNASVLNLLIISFDRYFSVTRPLTYRAKRTTNRAAVMIGAAWGISLLLWPPWIYSWPYIEGKRTVPKDECYIQFIETNQYITFGTALAAFYFPVTIMCFLYWRIWRETKKRQKDLPNLQAGKKDSSKRSNSSDENTVVNHASGGLLAFAQVGGNDHDTWRRPRSESSPDAESVYMTNMVIDSGYHGMHSRKSSIKSTNTIKKSYTCFGSIKEWCIAWWHSGREDSDDFAYEQEEPSDLGCTSMNVMRDNYSMGGSVSGVRPPSILLSDVSPTPLPRPPLASISQLQEMSAVTASTTANVNTSGNGNGAINNNNNASHNGNGAVNGNGAGNGSGIGLGTTGNATHRDSRTLPVINRINSRSVSQDSVYTILIRLPSDGASSNAANGGGGGPGAGAAASASLSMQGDCAPSIKMIHEDGPTTTAAAAPLASAAATRRPLPSRDSEFSLPLGRRMSHAQHDARLLNAKVIPKQLGKAGGGAAGGGVGGAHALMNARNAAKKKKKSQEKRQESKAAKTLSAILLSFIITWTPYNILVLIKPLTTCSDCIPTELWDFFYALCYINSTINPMCYALCNATFRRTYVRILTCKWHTRNREGMVRGVYN | |
| muscarinic acetylcholine Receptor, A-type, isoform B | |
|---|---|
| Refseq ID | NP_523844 |
| Protein GI | 24762612 |
| UniProt ID | P16395 |
| mRNA ID | NM_079120 |
| Length | 805 |
| RefSeq Status | REVIEWED |
| MEPVMSLALAAHGPPSILEPLFKTVTTSTTTTTTTTTSTTTTTASPAGYSPGYPGTTLLTALFENLTSTAASGLYDPYSGMYGNQTNGTIGFETKGPRYSLASMVVMGFVAAILSTVTVAGNVMVMISFKIDKQLQTISNYFLFSLAIADFAIGAISMPLFAVTTILGYWPLGPIVCDTWLALDYLASNASVLNLLIISFDRYFSVTRPLTYRAKRTTNRAAVMIGAAWGISLLLWPPWIYSWPYIEGKRTVPKDECYIQFIETNQYITFGTALAAFYFPVTIMCFLYWRIWRETKKRQKDLPNLQAGKKDSSKRSNSSDENTVVNHASGGLLAFAQVGGNDHDTWRRPRSESSPDAESVYMTNMVIDSGYHGMHSRKSSIKSTNTIKKSYTCFGSIKEWCIAWWHSGREDSDDFAYEQEEPSDLGYATPVTIETPLQSSVSRCTSMNVMRDNYSMGGSVSGVRPPSILLSDVSPTPLPRPPLASISQLQEMSAVTASTTANVNTSGNGNGAINNNNNASHNGNGAVNGNGAGNGSGIGLGTTGNATHRDSRTLPVINRINSRSVSQDSVYTILIRLPSDGASSNAANGGGGGPGAGAAASASLSMQGDCAPSIKMIHEDGPTTTAAAAPLASAAATRRPLPSRDSEFSLPLGRRMSHAQHDARLLNAKVIPKQLGKAGGGAAGGGVGGAHALMNARNAAKKKKKSQEKRQESKAAKTLSAILLSFIITWTPYNILVLIKPLTTCSDCIPTELWDFFYALCYINSTINPMCYALCNATFRRTYVRILTCKWHTRNREGMVRGVYN | |
Gene Information
Entrez Gene ID
Gene Name
muscarinic Acetylcholine Receptor, A-type
Gene Symbol
Species
Drosophila melanogaster
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0030054 | IEA:UniProtKB-KW | C | cell junction |
| GO:0016021 | ISS:FlyBase | C | integral component of membrane |
| GO:0005887 | IDA:FlyBase | C | integral component of plasma membrane |
| GO:0045211 | IEA:UniProtKB-KW | C | postsynaptic membrane |
| GO:0016907 | IDA:FlyBase | F | G-protein coupled acetylcholine receptor activity |
| GO:0008227 | ISS:FlyBase | F | G-protein coupled amine receptor activity |
| GO:0007213 | ISS:FlyBase | P | G-protein coupled acetylcholine receptor signaling pathway |
| GO:0007200 | IDA:FlyBase | P | phospholipase C-activating G-protein coupled receptor signaling pathway |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| dme04080 | Neuroactive ligand-receptor interaction |
REACTOME Pathway Links
Domain Information
UniProt Annotations
Entry Information
Gene Name
muscarinic Acetylcholine Receptor, A-type
Protein Entry
ACM1_DROME
UniProt ID
Species
Drosophila
Comments
| Comment Type | Description |
|---|---|
| Alternative Products | Event=Alternative splicing; Named isoforms=2; Name=B; IsoId=P16395-1; Sequence=Displayed; Name=A; IsoId=P16395-2; Sequence=VSP_012002; |
| Function | The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. May have a role in the processing of olfactory and mechanosensory signals; regulation of neurosecretion. {ECO:0000269|PubMed:2510174, ECO:0000269|PubMed:7550280}. |
| Sequence Caution | Sequence=AAA85449.1; Type=Frameshift; Positions=57; Evidence={ECO:0000305}; Sequence=ABF85716.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. E.coli genomic contaminant.; Evidence={ECO:0000305}; |
| Similarity | Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. {ECO:0000255|PROSITE- ProRule:PRU00521}. |
| Subcellular Location | Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. |
| Tissue Specificity | Intense staining in the glomeruli of the antennal lobes, the region of the nervous system containing terminals of antennal olfactory sensory neurons and mechanosensory neurons. Also a discrete group of neurosecretory cells in the pars intercerebralis of the brain. {ECO:0000269|PubMed:7550280}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP009044 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 24762610 | RefSeq | NP_726440 | 788 | muscarinic acetylcholine Receptor, A-type, isoform A |
| 24762612 | RefSeq | NP_523844 | 805 | muscarinic acetylcholine Receptor, A-type, isoform B |
Identical Sequences to LMP009044 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:24762610 | gnl | FlyBase | 788 | muscarinic acetylcholine Receptor, A-type, isoform A [Drosophila melanogaster] |
| GI:24762612 | gnl | FlyBase | 805 | muscarinic acetylcholine Receptor, A-type, isoform B [Drosophila melanogaster] |
| GI:24762612 | SwissProt | P16395.2 | 805 | RecName: Full=Muscarinic acetylcholine receptor DM1 [Drosophila melanogaster] |
Related Sequences to LMP009044 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:24762610 | GenBank | AAA28676.1 | 788 | muscarinic acetylcholine receptor [Drosophila melanogaster] |
| GI:24762612 | GenBank | AAA28676.1 | 788 | muscarinic acetylcholine receptor [Drosophila melanogaster] |
| GI:24762612 | GenBank | AEQ62993.1 | 805 | FI15221p1 [Drosophila melanogaster] |
| GI:24762610 | GenBank | AEQ62993.1 | 805 | FI15221p1 [Drosophila melanogaster] |
| GI:24762612 | GenBank | AFJ23964.1 | 788 | muscarinic acetylcholine receptor type A short variant [Drosophila melanogaster] |
| GI:24762610 | GenBank | AFJ23964.1 | 788 | muscarinic acetylcholine receptor type A short variant [Drosophila melanogaster] |
| GI:24762612 | GenBank | AFJ23965.1 | 805 | muscarinic acetylcholine receptor type A long variant [Drosophila melanogaster] |
| GI:24762612 | gnl | FlyBase | 788 | muscarinic acetylcholine Receptor, A-type, isoform A [Drosophila melanogaster] |
| GI:24762610 | gnl | FlyBase | 805 | muscarinic acetylcholine Receptor, A-type, isoform B [Drosophila melanogaster] |
| GI:24762612 | RefSeq | NP_726440.1 | 788 | muscarinic acetylcholine Receptor, A-type, isoform A [Drosophila melanogaster] |
| GI:24762610 | RefSeq | NP_523844.2 | 805 | muscarinic acetylcholine Receptor, A-type, isoform B [Drosophila melanogaster] |
| GI:24762610 | SwissProt | P16395.2 | 805 | RecName: Full=Muscarinic acetylcholine receptor DM1 [Drosophila melanogaster] |