Gene/Proteome Database (LMPD)
LMPD ID
LMP009070
Gene ID
Species
Drosophila melanogaster (Drosophila)
Gene Name
Odorant receptor co-receptor
Gene Symbol
Synonyms
83A.2; 83b; A45; CG10609; DmelOrco; Dmel\CG10609; DOR45; DOR83b; OR49; or83b; Or83b; OR83b; OR83B; ORCO; vainsA
Alternate Names
CG10609-PA; CG10609-PB; Orco-PA; Orco-PB; odorant receptor 83b; odorant receptor co-receptor; odorant receptor coreceptor; olfactory co-receptor; olfactory coreceptor; olfactory receptor co-receptor
Chromosome
3R
Map Location
83A2-83A2
Proteins
| odorant receptor co-receptor, isoform A | |
|---|---|
| Refseq ID | NP_524235 |
| Protein GI | 24644231 |
| UniProt ID | Q9VNB5 |
| mRNA ID | NM_079511 |
| Length | 486 |
| RefSeq Status | REVIEWED |
| Protein sequence is identical to GI:161078034 (mRNA isoform) | |
| odorant receptor co-receptor, isoform B | |
|---|---|
| Refseq ID | NP_001097687 |
| Protein GI | 161078034 |
| UniProt ID | Q9VNB5 |
| mRNA ID | NM_001104217 |
| Length | 486 |
| RefSeq Status | REVIEWED |
| MTTSMQPSKYTGLVADLMPNIRAMKYSGLFMHNFTGGSAFMKKVYSSVHLVFLLMQFTFILVNMALNAEEVNELSGNTITTLFFTHCITKFIYLAVNQKNFYRTLNIWNQVNTHPLFAESDARYHSIALAKMRKLFFLVMLTTVASATAWTTITFFGDSVKMVVDHETNSSIPVEIPRLPIKSFYPWNASHGMFYMISFAFQIYYVLFSMIHSNLCDVMFCSWLIFACEQLQHLKGIMKPLMELSASLDTYRPNSAALFRSLSANSKSELIHNEEKDPGTDMDMSGIYSSKADWGAQFRAPSTLQSFGGNGGGGNGLVNGANPNGLTKKQEMMVRSAIKYWVERHKHVVRLVAAIGDTYGAALLLHMLTSTIKLTLLAYQATKINGVNVYAFTVVGYLGYALAQVFHFCIFGNRLIEESSSVMEAAYSCHWYDGSEEAKTFVQIVCQQCQKAMSISGAKFFTVSLDLFASVLGAVVTYFMVLVQLK | |
Gene Information
Entrez Gene ID
Gene Name
Odorant receptor co-receptor
Gene Symbol
Species
Drosophila melanogaster
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0030425 | IDA:FlyBase | C | dendrite |
| GO:0016021 | IEA:UniProtKB-KW | C | integral component of membrane |
| GO:0005886 | IDA:FlyBase | C | plasma membrane |
| GO:0004930 | IEA:UniProtKB-KW | F | G-protein coupled receptor activity |
| GO:0005549 | IEA:InterPro | F | odorant binding |
| GO:0004984 | IDA:FlyBase | F | olfactory receptor activity |
| GO:0042803 | IPI:FlyBase | F | protein homodimerization activity |
| GO:0048149 | IMP:FlyBase | P | behavioral response to ethanol |
| GO:0050911 | IDA:GOC | P | detection of chemical stimulus involved in sensory perception of smell |
| GO:0042048 | IMP:FlyBase | P | olfactory behavior |
| GO:0051291 | IPI:FlyBase | P | protein heterooligomerization |
| GO:0019236 | IMP:FlyBase | P | response to pheromone |
| GO:0007608 | NAS:FlyBase | P | sensory perception of smell |
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR004117 | Olfactory receptor, Drosophila |
UniProt Annotations
Entry Information
Gene Name
Odorant receptor co-receptor
Protein Entry
OR83B_DROME
UniProt ID
Species
Drosophila
Comments
| Comment Type | Description |
|---|---|
| Developmental Stage | Expressed throughout all developmental stages. First expressed at embryonic stage 15. Pupal expression first occurs 80 hours after puparium formation. {ECO:0000269|PubMed:15339651}. |
| Function | Odorant coreceptor which complexes with conventional odorant receptors (ORs) to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. Orco is a universal and integral part of the functional odorant receptor, involved in the dendritic localization of other olfactory receptors. Expression of Orco alone leads to formation of rapid and transient ion channels not directly responding to odorants, but directly activated by intracellular cAMP or cGMP. Snmp, Or67d and lush act in concert to capture fatty-acid-derived male pheromone 11-cis vaccenyl acetate (cVA) molecules on the surface of Or67d expressing olfactory dendrites and facilitate their transfer to the odorant-receptor Orco complex. {ECO:0000269|PubMed:15339651, ECO:0000269|PubMed:15592462, ECO:0000269|PubMed:16402857, ECO:0000269|PubMed:17943085, ECO:0000269|PubMed:18408711, ECO:0000269|PubMed:18408712, ECO:0000269|PubMed:20147286, ECO:0000269|PubMed:21677030, ECO:0000269|PubMed:21937991}. |
| Miscellaneous | The atypical heteromeric and topological design of the odorant receptors appears to be an insect-specific solution for odor recognition, making the OR/Orco complex an attractive target for the development of highly selective insect repellents to disrupt olfactory-mediated host-seeking behaviors of insect disease vectors. Odor-evoked OR currents are independent of known G-protein-coupled second messenger pathways. The homomeric Orco channel is thought to be a cyclic-nucleotide-gated ion channel that depolarizes the olfactory receptor neuron. |
| Similarity | Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family. Orco subfamily. {ECO:0000305}. |
| Subcellular Location | Cell membrane {ECO:0000269|PubMed:16402857}; Multi-pass membrane protein {ECO:0000269|PubMed:16402857}. |
| Subunit | Heterodimer with conventional odorant receptors (ORs). Complexes exist early in the endomembrane system in olfactory sensory neurons (OSNs), coupling these complexes to the conserved ciliary trafficking pathway. |
| Tissue Specificity | Expression is restricted to olfactory sensory neurons (OSNs). Coexpressed with Snmp in a lateral-distal population of OSNs. Expressed in the embryonic antennal-maxillary complex, in all 21 OSNs of the larval dorsal organ, in the pupal antennal OSNs, in all 120 adult maxillary palp neurons and in approximately 70-80% of adult antennal OSNs, where expression is highest at the dorsal-medial edge. Localized to OSN cell bodies and to the distal portion of ciliated OSN dendrites. {ECO:0000269|PubMed:10089887, ECO:0000269|PubMed:10943836, ECO:0000269|PubMed:15339651, ECO:0000269|PubMed:16402857, ECO:0000269|PubMed:17943085}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP009070 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 161078034 | RefSeq | NP_001097687 | 486 | odorant receptor co-receptor, isoform B |
Identical Sequences to LMP009070 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:161078034 | GenBank | ABU34893.1 | 486 | Sequence 104 from patent US 7241881 |
| GI:161078034 | GenBank | ACS10701.1 | 486 | Sequence 6 from patent US 7541155 |
| GI:161078034 | GenBank | ACW03545.1 | 486 | Sequence 10 from patent US 7550574 |
| GI:161078034 | GenBank | ADA08702.1 | 486 | Sequence 10 from patent US 7601829 |
| GI:161078034 | GenBank | AGU31576.1 | 486 | Sequence 6 from patent US 8507013 |
| GI:161078034 | gnl | FlyBase | 486 | odorant receptor co-receptor, isoform B [Drosophila melanogaster] |
Related Sequences to LMP009070 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:161078034 | GenBank | AAT71306.1 | 486 | odorant receptor Or83b [Drosophila melanogaster] |
| GI:161078034 | GenBank | EDV47882.1 | 486 | GG11032 [Drosophila erecta] |
| GI:161078034 | GenBank | EDW95765.1 | 486 | GE25284 [Drosophila yakuba] |
| GI:161078034 | GenBank | AEO01718.1 | 490 | IP03309p1, partial [Drosophila melanogaster] |
| GI:161078034 | RefSeq | XP_001978924.1 | 486 | GG11032 [Drosophila erecta] |
| GI:161078034 | RefSeq | XP_002096053.1 | 486 | GE25284 [Drosophila yakuba] |