Gene/Proteome Database (LMPD)

LMPD ID
LMP009096
Gene ID
37733
Species
Drosophila melanogaster (Drosophila)
Gene Name
Phosphotidylinositol 3 kinase 59F
Gene Symbol
Pi3K59F
Synonyms
CG5373; Dmel\CG5373; DmVps34; dPI3K; dVps34; dVps34/PI3K59F; PI(3)K; PI3K; PI3K-59F; Pi3K_59F; PI3K_59F; PI[[3]]K; vps34; Vps34; VPS34
Chromosome
2R
Map Location
59E4-59F1

Proteins

phosphotidylinositol 3 kinase 59F
Refseq ID NP_477133
Protein GI 17137150
UniProt ID Q9W1M7
mRNA ID NM_057785
Length 949
RefSeq Status REVIEWED
MDQPDDHFRYIHSSSLHERVQIKVGTLEGKKRQPDYEKLLEDPILRFSGLYSEEHPSFQVRLQVFNQGRPYCLPVTSSYKAFGKRWSWNEWVTLPLQFSDLPRSAMLVLTILDCSGAGQTTVIGGTSISMFGKDGMFRQGMYDLRVWLGVEGDGNFPSRTPGKGKESSKSQMQRLGKLAKKHRNGQVQKVDWLDRLTFREIEVINEREKRMSDYMFLMIEFPAIVVDDMYNYAVVYFEPEGDVKYKLPAKPKLVSVPDSEIQMENLVERKHHRLARSERSGISDRDAKPTASIRDQLHTIVYRYPPTYVLSSEEQDLVWKFRFYLSSHKKALTKFLKCINWKLEDEVTQALWMLANWAPMDVEDALELLSPTFTHPQVRKYAVSRLAQAPDEDLLLYLLQLVQALKYEDPRHIVHLHGCIFPERDVVRSILDDNGSLLDQSSLSDLSATSSGLHGSVIPANQRAASVLAAIKSDKSVSPGSAGGSGSGGQGSVALPNPSAPATPGSSSLPCDSNSNALMLAEGISFGSVPANLCTFLIQRACTNATLANYFYWYLSIEVEEVESVRKQDERAHDMYAMVLKMFLKVLENGNFNLRGIFYNLRKQRRFIDELVKLVKLVAKEPGNRNKKTEKFQKLLAEQDMFKVNFTNFEPIPFPLDPEIYITKIVPMRTSLFKSALMPAKLTFVTSIAHHEYAAIFKHGDDLRQDQLILQMITLMDKLLRRENLDLKLTPYKVLATSSKHGFLQYVDSCTVAEVLAREGNIHNFFRKHHPCDNGPYGISAEVMDTYIKSCAGYCVITYLLGVGDRHLDNLLLTTNGKLFHIDFGYILGRDPKPMPPPMKLSKEMVEAMGGISSEHHHEFRKQCYTAYLHLRRHANVMLNLFSLMVDATVPDIALEPDKAVKKVEENLQLGLTDEEAVQHLQSLLDVSITAVMPALVEQIHRFTQYWRK

Gene Information

Entrez Gene ID
37733
Gene Name
Phosphotidylinositol 3 kinase 59F
Gene Symbol
Pi3K59F
Species
Drosophila melanogaster

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0000421 IDA:FlyBase C autophagic vacuole membrane
GO:0005769 IDA:FlyBase C early endosome
GO:0035032 NAS:FlyBase C phosphatidylinositol 3-kinase complex, class III
GO:0034271 IDA:FlyBase C phosphatidylinositol 3-kinase complex, class III, type I
GO:0016303 IDA:FlyBase F 1-phosphatidylinositol-3-kinase activity
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0035004 NAS:FlyBase F phosphatidylinositol 3-kinase activity
GO:0006914 IMP:FlyBase P autophagy
GO:0009267 IMP:FlyBase P cellular response to starvation
GO:0033227 IMP:FlyBase P dsRNA transport
GO:0006897 IMP:FlyBase P endocytosis
GO:0035096 IMP:FlyBase P larval midgut cell programmed cell death
GO:0046854 IDA:FlyBase P phosphatidylinositol phosphorylation
GO:0036092 IDA:GOC P phosphatidylinositol-3-phosphate biosynthetic process
GO:0048015 IEA:InterPro P phosphatidylinositol-mediated signaling
GO:0045850 IMP:FlyBase P positive regulation of nurse cell apoptotic process
GO:0010506 IMP:FlyBase P regulation of autophagy

Domain Information

InterPro Annotations

Accession Description
IPR016024 Armadillo-type fold
IPR000008 C2 domain
IPR000403 Phosphatidylinositol 3-/4-kinase, catalytic domain
IPR002420 Phosphatidylinositol 3-kinase, C2 domain
IPR008290 Phosphatidylinositol 3-kinase, Vps34 type
IPR018936 Phosphatidylinositol 3/4-kinase, conserved site
IPR015433 Phosphatidylinositol Kinase
IPR001263 Phosphoinositide 3-kinase, accessory (PIK) domain
IPR011009 Protein kinase-like domain

UniProt Annotations

Entry Information

Gene Name
Phosphotidylinositol 3 kinase 59F
Protein Entry
Q9W1M7_DROME
UniProt ID
Q9W1M7
Species
Drosophila

Comments

Comment Type Description
Catalytic Activity ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate.
Similarity Belongs to the PI3/PI4-kinase family.
Similarity Contains PI3K/PI4K domain.
Similarity Contains PIK helical domain.

Identical and Related Proteins

Unique RefSeq proteins for LMP009096 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
17137150 RefSeq NP_477133 949 phosphotidylinositol 3 kinase 59F

Identical Sequences to LMP009096 proteins

Reference Database Accession Length Protein Name
GI:17137150 GenBank AAL13591.1 949 GH13170p [Drosophila melanogaster]
GI:17137150 GenBank ACL85120.1 949 Pi3K59F-PA, partial [synthetic construct]
GI:17137150 gnl FlyBase 949 phosphotidylinositol 3 kinase 59F [Drosophila melanogaster]

Related Sequences to LMP009096 proteins

Reference Database Accession Length Protein Name
GI:17137150 EMBL CAA68185.1 949 1-phosphatidylinositol 3-kinase [Drosophila melanogaster]
GI:17137150 GenBank EDW56975.1 949 GM16028 [Drosophila sechellia]
GI:17137150 GenBank EDW92354.1 947 GE14305 [Drosophila yakuba]
GI:17137150 GenBank EDX08396.1 949 GD11777 [Drosophila simulans]
GI:17137150 RefSeq XP_002040110.1 949 GM16028 [Drosophila sechellia]
GI:17137150 RefSeq XP_002082811.1 949 GD11777 [Drosophila simulans]