Gene/Proteome Database (LMPD)
Proteins
CG7840 | |
---|---|
Refseq ID | NP_609203 |
Protein GI | 20129365 |
UniProt ID | Q9VLP9 |
mRNA ID | NM_135359 |
Length | 326 |
RefSeq Status | REVIEWED |
MAPPENGILEVLENLLDRYKINLLQMMFGTFIATIVFFGGLMTFVEKYLPNSIRQSFRYGKHSFKGETDPLVAWLEVPKSWFKHFYTFALFWSWLAFYVLVSTVREQKEAPEYVLQFLDIMGGGRSHRKVEIDSTTACVGAFMLTLQCTRRFYETNFVQIFSKKSKINLSHYAVGYVHYFGAVIALLSNTSGFVRGSKPMEFSLDKLTSQQILYLGVFFLAWQQQYASNMILVNLRKDPRTGSVKTEKHLLPKGGLFNLLSSPHMFLEVVMYFCIADLYMPVRIWRLIFLWVASNQTINALLTHKWYQETFREYPKNRRAIIPFLL |
Gene Information
Entrez Gene ID
Gene Name
CG7840 gene product from transcript CG7840-RA
Gene Symbol
Species
Drosophila melanogaster
Gene Ontology (GO Annotations)
GO ID | Source | Type | Description |
---|---|---|---|
GO:0005783 | IEA:UniProtKB-KW | C | endoplasmic reticulum |
GO:0016021 | IEA:UniProtKB-KW | C | integral component of membrane |
GO:0016627 | IEA:InterPro | F | oxidoreductase activity, acting on the CH-CH group of donors |
GO:0006488 | ISS:UniProtKB | P | dolichol-linked oligosaccharide biosynthetic process |
GO:0019348 | ISS:UniProtKB | P | dolichol metabolic process |
GO:0016095 | ISS:UniProtKB | P | polyprenol catabolic process |
GO:0006486 | IEA:UniProtKB-UniPathway | P | protein glycosylation |
REACTOME Pathway Links
Domain Information
InterPro Annotations
Accession | Description |
---|---|
IPR001104 | 3-oxo-5-alpha-steroid 4-dehydrogenase, C-terminal |
UniProt Annotations
Entry Information
Gene Name
CG7840 gene product from transcript CG7840-RA
Protein Entry
PORED_DROME
UniProt ID
Species
Drosophila
Comments
Comment Type | Description |
---|---|
Catalytic Activity | Ditrans,polycis-dolichol + NADP(+) = ditrans,polycis-polyprenol + NADPH. |
Function | Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism (By similarity). {ECO:0000250}. |
Interaction | Q9XYQ2:unc-119; NbExp=1; IntAct=EBI-88569, EBI-127298; |
Pathway | Protein modification; protein glycosylation. |
Sequence Caution | Sequence=AAM52687.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; |
Similarity | Belongs to the steroid 5-alpha reductase family. Polyprenol reductase subfamily. {ECO:0000305}. |
Subcellular Location | Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP009111 (as displayed in Record Overview)
Identical Sequences to LMP009111 proteins
Reference | Database | Accession | Length | Protein Name |
---|---|---|---|---|
GI:20129365 | gnl | FlyBase | 326 | CG7840 [Drosophila melanogaster] |
GI:20129365 | SwissProt | Q9VLP9.1 | 326 | RecName: Full=Polyprenol reductase [Drosophila melanogaster] |
Related Sequences to LMP009111 proteins
Reference | Database | Accession | Length | Protein Name |
---|---|---|---|---|
GI:20129365 | EMBL | CAL26219.1 | 326 | CG7840 [Drosophila melanogaster] |
GI:20129365 | EMBL | CAL26230.1 | 326 | CG7840 [Drosophila melanogaster] |
GI:20129365 | EMBL | CAL26235.1 | 326 | CG7840 [Drosophila melanogaster] |
GI:20129365 | EMBL | CAL26237.1 | 326 | CG7840 [Drosophila melanogaster] |
GI:20129365 | EMBL | CAR93292.1 | 326 | CG7840-PA [Drosophila melanogaster] |
GI:20129365 | GenBank | AAM52687.1 | 353 | LD35060p, partial [Drosophila melanogaster] |