Gene/Proteome Database (LMPD)

LMPD ID
LMP009128
Gene ID
44274
Species
Drosophila melanogaster (Drosophila)
Gene Name
dispatched
Gene Symbol
disp
Synonyms
anon-WO0146227.1; CG2019; Disp; Dmel\CG2019
Alternate Names
CG2019-PA; disp-PA; dispatched
Chromosome
3R
Map Location
83C5-83C5

Proteins

dispatched
Refseq ID NP_524734
Protein GI 24644456
UniProt ID Q9VNJ5
mRNA ID NM_079995
Length 1218
RefSeq Status REVIEWED
MLCFDSERMNWYYHVLARRPYLVVVSIAVYCVACIIVALVLNKLPDFSDPTLGFETRGTKIGERLTAWYNLLQETDHHGALFSNPSDLWERRRVEQGYVETKLHPNHRRRKNKHKNRNKNKRRKEQNQSSHEHHDVAQKMMQFKKRLKATSSPSPNLGFDTWIGDSGVFRDYEITNDSASSSLEPTRRTEQIEYGHNTTSVDEEEHQQRVQTKKSTWRLLKQAATLPTDGWADMHRRQPIEGFFCDSSPRKEYSHFVVQRIGPNATDSLFDLNGLLAMCQLQDQITEVPSYRAFCEPEMLTTECCRPWSLPNYAAMLANKSSCFDLTTEDVTSLHTLLLGCYEYFHDLKMDNHCNEIPHCRAPEECKRLNIVFNVLNFLTDFSFIKSNDSNVYLKYAMIFIPVAQSNRLLPLFHEWEDVELINELVEVVAMDLGLENELFNELLLTDVWLVSLGGTFVMASVWLYTGSAFITLMSCVAICFSLGLAYFFYAIVLEFEFFPYMNLLAVVVIIGIGADDVFLFLKIWHCVLTERFSNRCTLTTQSQSALPTLENSDHTESLENIMALTMRHAAASMFVTSLTTAGAFYASYSSSITAIKCFGIFAGTVVVTNYLLMITWLPASVSIMERLFATRMSCHHPMSIKLIHACKKSINRFCQMFEECITKSIMNYAYLWLLIFGALGASSAVIVFWYPGLQLPEKSHFQLFVSKHPFEVYSSLKQQFWFEKPLQAYENFKMHMHFVWGVQAVDDGDYTNPNSYGHLHYDNNFNVSSRPAQLWILDFCQSVRQQPFYKETLGMLLPNCFIENLIDYMKRRCIDDMDSTRKDRSPCCDAQFPFEPHIFEYCLPQSISNMYDTTFFRPGVAGPKFAEAPRLETEDYLGMSGNESAEYSTNGSFTPLLVKALVIEFESNVAYSTIYANIRQFYESVEHWFQMQLKTAPPELQGGWFTSDLKFYNVQDTLSHDTFVAICLAMAASLAVLLCFTVNILISIYAVLTVSLSIFNTVAVLILLGWQLNILESIAVSTAIGLAVDFSLHYGIHYRMSPVKERLAATQFVLSRIIGPTVMAATTTGLAGGIMMASNILPYIQIGVFLVVVMIVSWFYATFFLMSLLRVAGPQHGFLELKWPLWSKRSSGSSKFYERKPSQVIASEQLLTPTSSAIVELANSETHELESLNSNSLIKTISGIESAHALSSLPRDFEHSFQTMHECKYQTYPSTSN

Gene Information

Entrez Gene ID
44274
Gene Name
dispatched
Gene Symbol
disp
Species
Drosophila melanogaster

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016021 ISS:FlyBase C integral component of membrane
GO:0016020 NAS:FlyBase C membrane
GO:0008158 IEA:InterPro F hedgehog receptor activity
GO:0006887 TAS:FlyBase P exocytosis
GO:0007275 IEA:UniProtKB-KW P multicellular organismal development
GO:0007280 IGI:FlyBase P pole cell migration
GO:0007224 IMP:UniProtKB P smoothened signaling pathway

REACTOME Pathway Links

REACTOME Pathway ID Description
6227047 Hedgehog ligand biogenesis
6227049 Processing-defective Hh variants abrogate ligand secretion
6227054 Release of Hh-Np from the secreting cell
6227048 Signaling by Hedgehog

Domain Information

InterPro Annotations

Accession Description
IPR003392 Patched
IPR000731 Sterol-sensing domain

UniProt Annotations

Entry Information

Gene Name
dispatched
Protein Entry
DISP_DROME
UniProt ID
Q9VNJ5
Species
Drosophila

Comments

Comment Type Description
Developmental Stage Ubiquitously expressed throughout the embryo and the imaginal discs. {ECO:0000269|PubMed:10619433}.
Disruption Phenotype Death during embryogenesis with a strong segment-polarity phenotype. {ECO:0000269|PubMed:10619433}.
Function Segment polarity protein which functions in hedgehog (Hh) signaling. Regulates the trafficking and the release of cholesterol-modified hedgehog protein from cells of the posterior compartment (P cells) and is hence required for the effective production of the Hh signal. {ECO:0000269|PubMed:10619433, ECO:0000269|PubMed:12372301, ECO:0000269|PubMed:12586063}.
Similarity Belongs to the dispatched family. {ECO:0000305}.
Similarity Contains 1 SSD (sterol-sensing) domain. {ECO:0000255|PROSITE-ProRule:PRU00199}.
Subcellular Location Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.

Identical and Related Proteins

Unique RefSeq proteins for LMP009128 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
24644456 RefSeq NP_524734 1218 dispatched

Identical Sequences to LMP009128 proteins

Reference Database Accession Length Protein Name
GI:24644456 GenBank ACJ13136.1 1218 FI02022p [Drosophila melanogaster]
GI:24644456 gnl FlyBase 1218 dispatched [Drosophila melanogaster]
GI:24644456 SwissProt Q9VNJ5.1 1218 RecName: Full=Protein dispatched [Drosophila melanogaster]

Related Sequences to LMP009128 proteins

Reference Database Accession Length Protein Name
GI:24644456 EMBL CAC49985.1 1218 unnamed protein product [Drosophila melanogaster]
GI:24644456 GenBank AAF23397.1 1218 Dispatched [Drosophila melanogaster]
GI:24644456 GenBank AAV36904.1 1218 RE16243p [Drosophila melanogaster]
GI:24644456 GenBank EDV47965.1 1219 GG10787 [Drosophila erecta]
GI:24644456 GenBank EDW55033.1 1219 GM10585 [Drosophila sechellia]
GI:24644456 RefSeq XP_002038496.1 1219 GM10585 [Drosophila sechellia]