Gene/Proteome Database (LMPD)

LMPD ID
LMP009133
Gene ID
39297
Species
Drosophila melanogaster (Drosophila)
Gene Name
rotated abdomen
Gene Symbol
rt
Synonyms
CG6097; Dmel\CG6097; dPOMT1; DPOMT1; fs(3)neo1; pomt; POMT1; roa; Rot_abd
Chromosome
3L
Map Location
68C13-68C13

Proteins

rotated abdomen
Refseq ID NP_524025
Protein GI 24662757
UniProt ID Q9VTK2
mRNA ID NM_079301
Length 886
RefSeq Status REVIEWED
MSATYTNTITQRRKTAKVRNHQWTGSDLSGESNERLHFRSRSTNSMQQHTAISNSPSPLCCNGARALTMLNCCVDVNCHLNAPLRGSVNRHTTPTPTPTATPTPVATPKQASPSPTSDRSRSLSRSPSPSRSRSLSCQKQIDKNSAGAASAEERKTANASSQPFTVNLRIDLFSWTLFLLAFGTRFYKLATPPHIVFDELHYGKYISMYMRNIFFFDQHPPLGKQLIAGLVSLAGYDGNYTFTRIGEPYSPEMPIFWFRFLPAMCGSLLAPAVYNLLLEAKLSRWSSALGGLLVVLDNSLLTQSRFVLMESMLLLATTVGIACLLRFQRSRLGSLEWFFTGTAAAVCLGAAGTVKYVGFLALGLAFYLLCRHLWQLLYDAGLTDRQLWMHAISRLLIFVGIPLAVYLGVFYIHFKTLHRAGPHDSIMTSAFQASLDGGLASITKGQPLAVVHGSQITLRHTHGRTCWLHSHAAVYPVRYPDKRGSSHQQQVTCYSFKDVNNWWLVKRPTKENLVVGDEPDIIRHGEIIQLVHGITSRALNSHDVAAAMTPQCQEVSCYIDYEIKMAGELLWRVEILNRDSEGDIWHAIKSEVRLVHVSTEASLKFSGRQLPEWGFNQHEVVADREKAIHEDAIWNVEEHRYTQTEDHRERERQMLTAEMIPTKRTRISFWAKLLELQSKMLFQTKSVPNHMYSSMPHEWPLMDKGIAYWLDSQSSAQIYLLGNILLWYTATMGILVYAGLLAFYAMRRQRLCFDISEQEWQRFVLAGDTFFMGYVMHYIPYFCVDRTLFLHNYLPAFVFKLLLLCFVVEHLDYLLRRFCTGRGVHLVRLYRLMLILWLVGVLSIFSKFIPFSYGARKMTLNEVRSLRWKDTWDFVLHKNHHLY

Gene Information

Entrez Gene ID
39297
Gene Name
rotated abdomen
Gene Symbol
rt
Species
Drosophila melanogaster

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IDA:UniProtKB C endoplasmic reticulum
GO:0016021 ISS:FlyBase C integral component of membrane
GO:0004169 IDA:UniProtKB F dolichyl-phosphate-mannose-protein mannosyltransferase activity
GO:0030259 IMP:UniProtKB P lipid glycosylation
GO:0016203 IGI:FlyBase P muscle attachment
GO:0007517 IMP:UniProtKB P muscle organ development
GO:0035269 IDA:FlyBase P protein O-linked mannosylation
GO:0060025 IMP:FlyBase P regulation of synaptic activity
GO:0045214 IGI:FlyBase P sarcomere organization
GO:0007525 IMP:FlyBase P somatic muscle development
GO:0007385 IMP:UniProtKB P specification of segmental identity, abdomen

Domain Information

InterPro Annotations

Accession Description
IPR003342 Glycosyl transferase, family 39
IPR027005 Glycosyltransferase 39 like
IPR016093 MIR_motif

UniProt Annotations

Entry Information

Gene Name
rotated abdomen
Protein Entry
Q9VTK2_DROME
UniProt ID
Q9VTK2
Species
Drosophila

Comments

Comment Type Description
Catalytic Activity Dolichyl D-mannosyl phosphate + protein = dolichyl phosphate + O-D-mannosylprotein.
Developmental Stage Expressed both maternally and zygotically. Zygotic expression peaks at embryonic stages 8-16. {ECO:0000269|PubMed:15271988, ECO:0000269|PubMed:16219785, ECO:0000269|PubMed:8650217}.
Disruption Phenotype Death during development, the few adult escapers exhibit clockwise rotation of the abdomen and defects in embryonic muscle development. {ECO:0000269|PubMed:15271988, ECO:0000269|PubMed:8650217}.
Function Rt/POMT1 and tw/POMT2 function as a protein O- mannosyltransferase in association with each other to generate and maintain normal muscle development. {ECO:0000269|PubMed:15271988, ECO:0000269|PubMed:16219785, ECO:0000269|PubMed:8650217}.
Pathway Protein modification; protein glycosylation.
Sequence Caution Sequence=AAL48892.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence= ; Sequence=CAA65194.1; Type=Frameshift; Positions=118, 149, 567, 574, 585, 643, 649, 668, 688, 708, 720, 848, 856, 876; Evidence= ;
Similarity Belongs to the glycosyltransferase 39 family.
Similarity Contains 3 MIR domains. {ECO:0000255|PROSITE- ProRule:PRU00131}.
Subcellular Location Endoplasmic reticulum membrane ; Multi-pass membrane protein .
Subunit Interacts with tw/POMT2.
Tissue Specificity At the cellular blastoderm stage, expression accumulates in the ventrally located mesoderm primordium. At germ band extension, mesoderm expression is seen as stripes of strong expression. A very strong signal is also detected in the invaginating gut. As the germ band retracts, mesodermal expression decays and becomes restricted to somatic muscle precursors. After dorsal closure, expression has disappeared from the mesoderm and remains in the endoderm. Some expression is detected in a few cells of the head and the pharyngeal muscles.

Identical and Related Proteins

Unique RefSeq proteins for LMP009133 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
24662757 RefSeq NP_524025 886 rotated abdomen

Identical Sequences to LMP009133 proteins

Reference Database Accession Length Protein Name
GI:24662757 gnl FlyBase 886 rotated abdomen [Drosophila melanogaster]
GI:24662757 SwissProt Q9VTK2.2 886 RecName: Full=Protein O-mannosyltransferase 1; AltName: Full=Dolichyl-phosphate-mannose--protein mannosyltransferase 1; Short=dPOMT1; AltName: Full=Protein rotated abdomen [Drosophila melanogaster]

Related Sequences to LMP009133 proteins

Reference Database Accession Length Protein Name
GI:24662757 DBBJ BAD54754.1 886 protein O-mannosyltransferase 1 [Drosophila melanogaster]
GI:24662757 GenBank EDW41120.1 889 GM24735 [Drosophila sechellia]
GI:24662757 GenBank EDX10095.1 889 GD12795 [Drosophila simulans]
GI:24662757 RefSeq XP_002030134.1 889 GM24735 [Drosophila sechellia]
GI:24662757 RefSeq XP_002094440.1 892 GE20200 [Drosophila yakuba]
GI:24662757 RefSeq XP_002084510.1 889 GD12795 [Drosophila simulans]