Gene/Proteome Database (LMPD)

LMPD ID
LMP009135
Gene ID
35851
Species
Drosophila melanogaster (Drosophila)
Gene Name
patched
Gene Symbol
ptc
Synonyms
BcDNA:RH36596; CG2411; com4; Conf; Dmel\CG2411; dPtc; l(2)k02507; pat; Ptc; PTC; ptch; Ptch; Ptc_Dm; rubr; tuf
Alternate Names
CG2411-PA; compaction defects 4; confused; patch; patched; ptc-PA; rubberneck; tufted
Chromosome
2R
Map Location
44D5-44E1

Proteins

patched
Refseq ID NP_523661
Protein GI 24586628
UniProt ID P18502
mRNA ID NM_078937
Length 1286
RefSeq Status REVIEWED
MDRDSLPRVPDTHGDVVDEKLFSDLYIRTSWVDAQVALDQIDKGKARGSRTAIYLRSVFQSHLETLGSSVQKHAGKVLFVAILVLSTFCVGLKSAQIHSKVHQLWIQEGGRLEAELAYTQKTIGEDESATHQLLIQTTHDPNASVLHPQALLAHLEVLVKATAVKVHLYDTEWGLRDMCNMPSTPSFEGIYYIEQILRHLIPCSIITPLDCFWEGSQLLGPESAVVIPGLNQRLLWTTLNPASVMQYMKQKMSEEKISFDFETVEQYMKRAAIGSGYMEKPCLNPLNPNCPDTAPNKNSTQPPDVGAILSGGCYGYAAKHMHWPEELIVGGAKRNRSGHLRKAQALQSVVQLMTEKEMYDQWQDNYKVHHLGWTQEKAAEVLNAWQRNFSREVEQLLRKQSRIATNYDIYVFSSAALDDILAKFSHPSALSIVIGVAVTVLYAFCTLLRWRDPVRGQSSVGVAGVLLMCFSTAAGLGLSALLGIVFNAASTQVVPFLALGLGVDHIFMLTAAYAESNRREQTKLILKKVGPSILFSACSTAGSFFAAAFIPVPALKVFCLQAAIVMCSNLAAALLVFPAMISLDLRRRTAGRADIFCCCFPVWKEQPKVAPPVLPLNNNNGRGARHPKSCNNNRVPLPAQNPLLEQRADIPGSSHSLASFSLATFAFQHYTPFLMRSWVKFLTVMGFLAALISSLYASTRLQDGLDIIDLVPKDSNEHKFLDAQTRLFGFYSMYAVTQGNFEYPTQQQLLRDYHDSFVRVPHVIKNDNGGLPDFWLLLFSEWLGNLQKIFDEEYRDGRLTKECWFPNASSDAILAYKLIVQTGHVDNPVDKELVLTNRLVNSDGIINQRAFYNYLSAWATNDVFAYGASQGKLYPEPRQYFHQPNEYDLKIPKSLPLVYAQMPFYLHGLTDTSQIKTLIGHIRDLSVKYEGFGLPNYPSGIPFIFWEQYMTLRSSLAMILACVLLAALVLVSLLLLSVWAAVLVILSVLASLAQIFGAMTLLGIKLSAIPAVILILSVGMMLCFNVLISLGFMTSVGNRQRRVQLSMQMSLGPLVHGMLTSGVAVFMLSTSPFEFVIRHFCWLLLVVLCVGACNSLLVFPILLSMVGPEAELVPLEHPDRISTPSPLPVRSSKRSGKSYVVQGSRSSRGSCQKSHHHHHKDLNDPSLTTITEEPQSWKSSNSSIQMPNDWTYQPREQRPASYAAPPPAYHKAAAQQHHQHQGPPTTPPPPFPTAYPPELQSIVVQPEVTVETTHSDSNTTKVTATANIKVELAMPGRAVRSYNFTS

Gene Information

Entrez Gene ID
35851
Gene Name
patched
Gene Symbol
ptc
Species
Drosophila melanogaster

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IDA:FlyBase C cytoplasm
GO:0030139 IDA:FlyBase C endocytic vesicle
GO:0016021 TAS:FlyBase C integral component of membrane
GO:0005887 IDA:FlyBase C integral component of plasma membrane
GO:0048471 IDA:FlyBase C perinuclear region of cytoplasm
GO:0005886 IDA:FlyBase C plasma membrane
GO:0008158 IMP:FlyBase F hedgehog receptor activity
GO:0030228 IDA:FlyBase F lipoprotein particle receptor activity
GO:0004888 NAS:FlyBase F transmembrane signaling receptor activity
GO:0001746 IMP:FlyBase P Bolwig's organ morphogenesis
GO:0048099 TAS:FlyBase P anterior/posterior lineage restriction, imaginal disc
GO:0009952 NAS:FlyBase P anterior/posterior pattern specification
GO:0007411 IMP:FlyBase P axon guidance
GO:0016311 TAS:FlyBase P dephosphorylation
GO:0035225 IMP:FlyBase P determination of genital disc primordium
GO:0009880 TAS:FlyBase P embryonic pattern specification
GO:0007455 IMP:FlyBase P eye-antennal disc morphogenesis
GO:0042078 TAS:FlyBase P germ-line stem cell division
GO:0008406 IMP:FlyBase P gonad development
GO:0007476 IMP:FlyBase P imaginal disc-derived wing morphogenesis
GO:0055088 IMP:FlyBase P lipid homeostasis
GO:0045879 IGI:FlyBase P negative regulation of smoothened signaling pathway
GO:0048477 IMP:FlyBase P oogenesis
GO:0030707 TAS:FlyBase P ovarian follicle cell development
GO:0007422 TAS:FlyBase P peripheral nervous system development
GO:0006508 TAS:FlyBase P proteolysis
GO:0006898 IDA:GOC P receptor-mediated endocytosis
GO:0042981 IGI:FlyBase P regulation of apoptotic process
GO:2000274 IMP:FlyBase P regulation of epithelial cell migration, open tracheal system
GO:0007346 IMP:FlyBase P regulation of mitotic cell cycle
GO:0042306 IMP:FlyBase P regulation of protein import into nucleus
GO:0007367 IEA:UniProtKB-KW P segment polarity determination
GO:0007224 IMP:FlyBase P smoothened signaling pathway
GO:0048103 TAS:FlyBase P somatic stem cell division
GO:0048100 TAS:FlyBase P wing disc anterior/posterior pattern formation

KEGG Pathway Links

KEGG Pathway ID Description
dme04340 Hedgehog signaling pathway
ko04340 Hedgehog signaling pathway

REACTOME Pathway Links

REACTOME Pathway ID Description
6226522 Class B/2 (Secretin family receptors)

Domain Information

InterPro Annotations

Accession Description
IPR003392 Patched
IPR000731 Sterol-sensing domain
IPR004766 Transmembrane receptor, patched

UniProt Annotations

Entry Information

Gene Name
patched
Protein Entry
PTC_DROME
UniProt ID
P18502
Species
Drosophila

Comments

Comment Type Description
Function Segmentation polarity protein. Acts as a receptor for the hedgehog protein (HH). Associates with the smoothened protein (SMO) to transduce the hedgehog signal leading to the activation of wingless, decapentaplegic and patched itself. Participates in cell interactions that establish pattern within the segment and the imaginal disks during development. In the absence of HH, represses the constitutive signaling activity of smo through fused (FU).
Similarity Belongs to the patched family. {ECO:0000305}.
Similarity Contains 1 SSD (sterol-sensing) domain. {ECO:0000255|PROSITE-ProRule:PRU00199}.
Subcellular Location Membrane; Multi-pass membrane protein.

Identical and Related Proteins

Unique RefSeq proteins for LMP009135 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
24586628 RefSeq NP_523661 1286 patched

Identical Sequences to LMP009135 proteins

Reference Database Accession Length Protein Name
GI:24586628 gnl FlyBase 1286 patched [Drosophila melanogaster]
GI:24586628 SwissProt P18502.2 1286 RecName: Full=Protein patched; AltName: Full=Hedgehog receptor [Drosophila melanogaster]

Related Sequences to LMP009135 proteins

Reference Database Accession Length Protein Name
GI:24586628 EMBL CAJ18814.1 1299 unnamed protein product [Drosophila melanogaster]
GI:24586628 GenBank AAA28696.1 1286 membrane protein [Drosophila melanogaster]
GI:24586628 GenBank EDV59493.1 1286 GG23375 [Drosophila erecta]
GI:24586628 GenBank EDW46969.1 1286 GM21054 [Drosophila sechellia]
GI:24586628 RefSeq XP_001970434.1 1286 GG23375 [Drosophila erecta]
GI:24586628 RefSeq XP_002032956.1 1286 GM21054 [Drosophila sechellia]