Gene/Proteome Database (LMPD)
LMPD ID
LMP009141
Gene ID
Species
Drosophila melanogaster (Drosophila)
Gene Name
spinster
Gene Symbol
Synonyms
25/11; bnch; CG8428; Dmel\CG8428; l(2)10403; l(2)k02511; l(2)k09905; l(2)W5; l(2R)W5; Spin
Alternate Names
CG8428-PA; CG8428-PB; CG8428-PC; CG8428-PD; CG8428-PE; Spinster/Benchwarmer; benchwarmer; diphthong; lethal (2) W5; spin-PA; spin-PB; spin-PC; spin-PD; spin-PE; spinster
Chromosome
2R
Map Location
52E6-52E
Proteins
| spinster, isoform A | |
|---|---|
| Refseq ID | NP_725531 |
| Protein GI | 24654039 |
| UniProt ID | Q9GQQ0 |
| mRNA ID | NM_166145 |
| Length | 605 |
| RefSeq Status | REVIEWED |
| MSLKHQKQSYQPLPTAAAMDNPAMIQSSGSSGSSSSEEGGSREDVANLSPLGLPTTYSSQQLMPSDTDSMEEERHRLRPHHHHHHPLGEHHHIPGIPPSAVVPSRLSSVGRSQWFTVTVLCFVNLINYMDRFTIAGVLTDVRNDFDIGNDSAGLLQTVFVISYMVCAPIFGYLGDRYSRPWIMAVGVGLWSTTTLLGSFMKQFGWFIAFRALVGIGEASYSTIAPTIISDLFVHDMRSKMLALFYFAIPVGSGLGYIVGSKTAHLANDWRWALRVTPILGIVAVFLILLIKDPVRGHSEGSHNLEATTYKQDIKALVRNRSFMLSTAGFTCVAFVAGALAWWGPSFIYLGMKMQPGNENIVQDDVAFNFGVITMLAGLLGVPLGSFLSQYLVKRYPTADPVICAFGLLVSAPLLTGACLLVNSNSVGTYALIFFGQLALNLNWAIVADILLYVVVPTRRSTAEAFQILISHALGDAGSPYLVGAISEAIMKHLHKNPSDSGLTTELRSMSQVAGSAISNATQVIAEATTSLMETARSSASQEYSDVEQFEGLQYALFSTSFVEVLGGIFFIFTACFIIKDKYNATRGLQDATANRDERGQIA | |
| spinster, isoform B | |
|---|---|
| Refseq ID | NP_725532 |
| Protein GI | 24654041 |
| UniProt ID | Q9GQQ0 |
| mRNA ID | NM_166146 |
| Length | 630 |
| RefSeq Status | REVIEWED |
| MSLKHQKQSYQPLPTAAAMDNPAMIQSSGSSGSSSSEEGGSREDVANLSPLGLPTTYSSQQLMPSDTDSMEEERHRLRPHHHHHHPLGEHHHIPGIPPSAVVPSRLSSVGRSQWFTVTVLCFVNLINYMDRFTIAGVLTDVRNDFDIGNDSAGLLQTVFVISYMVCAPIFGYLGDRYSRPWIMAVGVGLWSTTTLLGSFMKQFGWFIAFRALVGIGEASYSTIAPTIISDLFVHDMRSKMLALFYFAIPVGSGLGYIVGSKTAHLANDWRWALRVTPILGIVAVFLILLIKDPVRGHSEGSHNLEATTYKQDIKALVRNRSFMLSTAGFTCVAFVAGALAWWGPSFIYLGMKMQPGNENIVQDDISYKFGLVAMLAGLIGVPLGSFLAQRLRGRYENCDPYICAVGLFISAPMVFAALVVPQTSESLCFFFVFVAQVALNLCWSIVADILLYVVVPTRRSTAEAFQILISHALGDAGSPYLVGAISEAIMKHLHKNPSDSGLTTELRSMSQVAGSAISNATQVIAEATTSLMETARSSASQEYSDVEQFEGLQYALFSTSFVEVLGGIFFIFTACFIIKDKYNATRGLQGDQGAQAVRSSVALASGQKDVESFNSDCLVLCTDIALRERT | |
| spinster, isoform C | |
|---|---|
| Refseq ID | NP_725530 |
| Protein GI | 24654037 |
| UniProt ID | Q9GQQ0 |
| mRNA ID | NM_166144 |
| Length | 605 |
| RefSeq Status | REVIEWED |
| MSLKHQKQSYQPLPTAAAMDNPAMIQSSGSSGSSSSEEGGSREDVANLSPLGLPTTYSSQQLMPSDTDSMEEERHRLRPHHHHHHPLGEHHHIPGIPPSAVVPSRLSSVGRSQWFTVTVLCFVNLINYMDRFTIAGVLTDVRNDFDIGNDSAGLLQTVFVISYMVCAPIFGYLGDRYSRPWIMAVGVGLWSTTTLLGSFMKQFGWFIAFRALVGIGEASYSTIAPTIISDLFVHDMRSKMLALFYFAIPVGSGLGYIVGSKTAHLANDWRWALRVTPILGIVAVFLILLIKDPVRGHSEGSHNLEATTYKQDIKALVRNRSFMLSTAGFTCVAFVAGALAWWGPSFIYLGMKMQPGNENIVQDDISYKFGLVAMLAGLIGVPLGSFLAQRLRGRYENCDPYICAVGLFISAPMVFAALVVPQTSESLCFFFVFVAQVALNLCWSIVADILLYVVVPTRRSTAEAFQILISHALGDAGSPYLVGAISEAIMKHLHKNPSDSGLTTELRSMSQVAGSAISNATQVIAEATTSLMETARSSASQEYSDVEQFEGLQYALFSTSFVEVLGGIFFIFTACFIIKDKYNATRGLQDATANRDERGQIA | |
| spinster, isoform D | |
|---|---|
| Refseq ID | NP_524823 |
| Protein GI | 17864456 |
| UniProt ID | Q9GQQ0 |
| mRNA ID | NM_080084 |
| Length | 630 |
| RefSeq Status | REVIEWED |
| MSLKHQKQSYQPLPTAAAMDNPAMIQSSGSSGSSSSEEGGSREDVANLSPLGLPTTYSSQQLMPSDTDSMEEERHRLRPHHHHHHPLGEHHHIPGIPPSAVVPSRLSSVGRSQWFTVTVLCFVNLINYMDRFTIAGVLTDVRNDFDIGNDSAGLLQTVFVISYMVCAPIFGYLGDRYSRPWIMAVGVGLWSTTTLLGSFMKQFGWFIAFRALVGIGEASYSTIAPTIISDLFVHDMRSKMLALFYFAIPVGSGLGYIVGSKTAHLANDWRWALRVTPILGIVAVFLILLIKDPVRGHSEGSHNLEATTYKQDIKALVRNRSFMLSTAGFTCVAFVAGALAWWGPSFIYLGMKMQPGNENIVQDDVAFNFGVITMLAGLLGVPLGSFLSQYLVKRYPTADPVICAFGLLVSAPLLTGACLLVNSNSVGTYALIFFGQLALNLNWAIVADILLYVVVPTRRSTAEAFQILISHALGDAGSPYLVGAISEAIMKHLHKNPSDSGLTTELRSMSQVAGSAISNATQVIAEATTSLMETARSSASQEYSDVEQFEGLQYALFSTSFVEVLGGIFFIFTACFIIKDKYNATRGLQGDQGAQAVRSSVALASGQKDVESFNSDCLVLCTDIALRERT | |
| spinster, isoform E | |
|---|---|
| Refseq ID | NP_725533 |
| Protein GI | 24654044 |
| UniProt ID | Q9GQQ0 |
| mRNA ID | NM_166147 |
| Length | 402 |
| RefSeq Status | REVIEWED |
| MSLKHQKQSYQPLPTAAAMDNPAMIQSSGSSGSSSSEEGGSREDVANLSPLGLPTTYSSQQLMPSDTDSMEEERHRLRPHHHHHHPLGEHHHIPGIPPSAVVPSRLSSVGRSQWFTVTVLCFVNLINYMDRFTIAGVLTDVRNDFDIGNDSAGLLQTVFVISYMVCAPIFGYLGDRYSRPWIMAVGVGLWSTTTLLGSFMKQFGWFIAFRALVGIGEASYSTIAPTIISDLFVHDMRSKMLALFYFAIPVGSGLGYIVGSKTAHLANDWRWALRVTPILGIVAVFLILLIKDPVRGHSEGSHNLEATTYKQDIKALVRNRSFMLSTAGFTCVAFVAGALAWWGPSFIYLGMKMQPGNENIVQDDMWWFPRDVQQPRPSKSSSHTHSVMPAVRIWLEQSPRPS | |
Gene Information
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0016021 | IEA:UniProtKB-KW | C | integral component of membrane |
| GO:0031902 | IDA:UniProtKB | C | late endosome membrane |
| GO:0005764 | IEA:UniProtKB-KW | C | lysosome |
| GO:0031982 | IDA:FlyBase | C | vesicle |
| GO:0009267 | IMP:FlyBase | P | cellular response to starvation |
| GO:0007619 | NAS:FlyBase | P | courtship behavior |
| GO:0006897 | IMP:FlyBase | P | endocytosis |
| GO:0008333 | IMP:FlyBase | P | endosome to lysosome transport |
| GO:0010001 | IMP:FlyBase | P | glial cell differentiation |
| GO:0008347 | IMP:FlyBase | P | glial cell migration |
| GO:0035193 | IMP:FlyBase | P | larval central nervous system remodeling |
| GO:0006869 | IEA:UniProtKB-KW | P | lipid transport |
| GO:0040011 | IMP:FlyBase | P | locomotion |
| GO:0007040 | IMP:FlyBase | P | lysosome organization |
| GO:0090099 | IGI:FlyBase | P | negative regulation of decapentaplegic signaling pathway |
| GO:0045476 | IMP:FlyBase | P | nurse cell apoptotic process |
| GO:0048477 | IMP:FlyBase | P | oogenesis |
| GO:0007422 | NAS:FlyBase | P | peripheral nervous system development |
| GO:0012501 | NAS:FlyBase | P | programmed cell death |
| GO:0045924 | IMP:FlyBase | P | regulation of female receptivity |
| GO:0045477 | IMP:FlyBase | P | regulation of nurse cell apoptotic process |
| GO:0043067 | IMP:FlyBase | P | regulation of programmed cell death |
| GO:0008582 | IMP:FlyBase | P | regulation of synaptic growth at neuromuscular junction |
| GO:0051124 | IMP:UniProtKB | P | synaptic growth at neuromuscular junction |
| GO:0048488 | IMP:FlyBase | P | synaptic vesicle endocytosis |
| GO:0055085 | IEA:InterPro | P | transmembrane transport |
Domain Information
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Alternative Products | Event=Alternative splicing; Named isoforms=5; Name=A; Synonyms=Type IV; IsoId=Q9GQQ0-1; Sequence=Displayed; Name=B; Synonyms=Type I; IsoId=Q9GQQ0-2; Sequence=VSP_036367, VSP_036368; Name=C; Synonyms=Type III; IsoId=Q9GQQ0-3; Sequence=VSP_036367; Name=D; Synonyms=Type II; IsoId=Q9GQQ0-4; Sequence=VSP_036368; Name=E; Synonyms=Type V; IsoId=Q9GQQ0-5; Sequence=VSP_036366; Note=Ref.1 (AAG43829) sequence is in conflict in position: 389:P->Q. {ECO:0000305}; |
| Developmental Stage | Expressed in both motoneurons and muscle throughout the period of synaptic growth and development at the neuromuscular junction. Expressed throughout the CNS, including motoneurons. Weak expression is observed in embryonic muscle as well as other tissues. Expressed throughout the larval CNS with pronounced expression in motoneurons. Also strongly expressed in all body wall muscle as well as other tissues, including a subset of epithelial cells and the salivary glands. {ECO:0000269|PubMed:12408844}. |
| Disruption Phenotype | In most cases, death at the late pupal stage, probably due to lipid accumulation in endosomes/lysosomes. Some flies survive until adulthood and display a strong rejection behavior of female flies in response to male courtship accompanied by decreases in the viability, adult life span, and oviposition rate of the flies. Some oocytes and adult neural cells undergo degeneration, which is preceded by reductions in programmed cell death of nurse cells in ovaries and of neurons in the pupal nervous system, respectively. The central nervous system (CNS) of flies accumulates lipopigments. Flies also display a strong synaptic overgrowth: synapses reveal a strong increase in bouton number and a deficit in presynaptic release caused by enhanced/misregulated TGF-beta signaling. A widespread accumulation of enlarged lysosomal and late endosomal inclusions is also present in yolk spheres during oogenesis. {ECO:0000269|PubMed:11340170, ECO:0000269|PubMed:12408844, ECO:0000269|PubMed:15998804}. |
| Function | Probable sphingolipid transporter that plays a central role in endosomes and/or lysosomes storage. Involved in TGF-beta- mediated synaptic growth regulation both pre- and postsynaptically via its function in endosomal storage regulation. Also required during oogenesis by regulating yolk spheres storage. {ECO:0000269|PubMed:12408844, ECO:0000269|PubMed:15998804}. |
| Sequence Caution | Sequence=AAK93216.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; |
| Similarity | Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family. {ECO:0000305}. |
| Subcellular Location | Late endosome membrane {ECO:0000269|PubMed:12408844}; Multi-pass membrane protein {ECO:0000269|PubMed:12408844}. Lysosome membrane {ECO:0000269|PubMed:12408844}; Multi-pass membrane protein {ECO:0000269|PubMed:12408844}. |
| Tissue Specificity | Enriched in brain (at protein level). {ECO:0000269|PubMed:12408844, ECO:0000269|PubMed:15998804}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP009141 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 24654039 | RefSeq | NP_725531 | 605 | spinster, isoform A |
| 24654041 | RefSeq | NP_725532 | 630 | spinster, isoform B |
| 24654037 | RefSeq | NP_725530 | 605 | spinster, isoform C |
| 17864456 | RefSeq | NP_524823 | 630 | spinster, isoform D |
| 24654044 | RefSeq | NP_725533 | 402 | spinster, isoform E |
Identical Sequences to LMP009141 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:24654041 | GenBank | AAG43825.1 | 630 | spinster type I [Drosophila melanogaster] |
| GI:17864456 | GenBank | AAG43826.1 | 630 | spinster type II [Drosophila melanogaster] |
| GI:24654037 | GenBank | AAG43827.1 | 605 | spinster type III [Drosophila melanogaster] |
| GI:24654039 | GenBank | AAG43828.1 | 605 | spinster type IV [Drosophila melanogaster] |
| GI:24654037 | GenBank | ACD81856.1 | 605 | LD31602p [Drosophila melanogaster] |
| GI:24654039 | GenBank | AGL46748.1 | 605 | GH09820p1 [Drosophila melanogaster] |
| GI:24654037 | gnl | FlyBase | 605 | spinster, isoform C [Drosophila melanogaster] |
| GI:24654039 | gnl | FlyBase | 605 | spinster, isoform A [Drosophila melanogaster] |
| GI:24654041 | gnl | FlyBase | 630 | spinster, isoform B [Drosophila melanogaster] |
| GI:17864456 | gnl | FlyBase | 630 | spinster, isoform D [Drosophila melanogaster] |
| GI:24654044 | gnl | FlyBase | 402 | spinster, isoform E [Drosophila melanogaster] |
| GI:24654039 | SwissProt | Q9GQQ0.1 | 605 | RecName: Full=Protein spinster; AltName: Full=Protein benchwarmer; AltName: Full=Protein diphthong [Drosophila melanogaster] |
Related Sequences to LMP009141 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:24654044 | GenBank | AAG43825.1 | 630 | spinster type I [Drosophila melanogaster] |
| GI:24654041 | GenBank | AAG43826.1 | 630 | spinster type II [Drosophila melanogaster] |
| GI:24654039 | GenBank | AAG43826.1 | 630 | spinster type II [Drosophila melanogaster] |
| GI:24654041 | GenBank | AAG43827.1 | 605 | spinster type III [Drosophila melanogaster] |
| GI:17864456 | GenBank | AAG43828.1 | 605 | spinster type IV [Drosophila melanogaster] |
| GI:24654044 | GenBank | AAG43829.1 | 402 | spinster type V [Drosophila melanogaster] |
| GI:24654041 | GenBank | ACD81856.1 | 605 | LD31602p [Drosophila melanogaster] |
| GI:24654037 | GenBank | EDV55817.1 | 605 | GG20571 [Drosophila erecta] |
| GI:24654037 | GenBank | EDW48080.1 | 605 | GM21663 [Drosophila sechellia] |
| GI:17864456 | GenBank | AFV15811.1 | 605 | AT25382p1 [Drosophila melanogaster] |
| GI:24654039 | GenBank | AFV15811.1 | 605 | AT25382p1 [Drosophila melanogaster] |
| GI:24654044 | GenBank | AGL46748.1 | 605 | GH09820p1 [Drosophila melanogaster] |
| GI:17864456 | GenBank | AGL46748.1 | 605 | GH09820p1 [Drosophila melanogaster] |
| GI:24654039 | gnl | FlyBase | 605 | spinster, isoform C [Drosophila melanogaster] |
| GI:24654041 | gnl | FlyBase | 605 | spinster, isoform C [Drosophila melanogaster] |
| GI:17864456 | gnl | FlyBase | 605 | spinster, isoform A [Drosophila melanogaster] |
| GI:24654044 | gnl | FlyBase | 630 | spinster, isoform B [Drosophila melanogaster] |
| GI:24654037 | gnl | FlyBase | 630 | spinster, isoform B [Drosophila melanogaster] |
| GI:24654041 | gnl | FlyBase | 630 | spinster, isoform D [Drosophila melanogaster] |
| GI:24654039 | gnl | FlyBase | 630 | spinster, isoform D [Drosophila melanogaster] |
| GI:24654039 | RefSeq | NP_524823.1 | 630 | spinster, isoform D [Drosophila melanogaster] |
| GI:24654041 | RefSeq | NP_725530.1 | 605 | spinster, isoform C [Drosophila melanogaster] |
| GI:24654039 | RefSeq | NP_725530.1 | 605 | spinster, isoform C [Drosophila melanogaster] |
| GI:24654044 | RefSeq | NP_725531.1 | 605 | spinster, isoform A [Drosophila melanogaster] |
| GI:17864456 | RefSeq | NP_725531.1 | 605 | spinster, isoform A [Drosophila melanogaster] |
| GI:24654037 | RefSeq | NP_725532.1 | 630 | spinster, isoform B [Drosophila melanogaster] |
| GI:24654044 | RefSeq | NP_725532.1 | 630 | spinster, isoform B [Drosophila melanogaster] |
| GI:24654037 | RefSeq | XP_001975417.1 | 605 | GG20571 [Drosophila erecta] |
| GI:24654037 | RefSeq | XP_002034067.1 | 605 | GM21663 [Drosophila sechellia] |
| GI:17864456 | SwissProt | Q9GQQ0.1 | 605 | RecName: Full=Protein spinster; AltName: Full=Protein benchwarmer; AltName: Full=Protein diphthong [Drosophila melanogaster] |