Gene/Proteome Database (LMPD)

LMPD ID
LMP009156
Gene ID
38396
Species
Drosophila melanogaster (Drosophila)
Gene Name
CG12034 gene product from transcript CG12034-RA
Gene Symbol
CG12034
Synonyms
Dmel\CG12034; nSMase
Alternate Names
CG12034; CG12034-PA
Chromosome
3L
Map Location
63B14-63B14
EC Number
3.1.4.12

Proteins

CG12034
Refseq ID NP_647790
Protein GI 21357231
UniProt ID Q9VZS6
mRNA ID NM_139533
Length 442
RefSeq Status REVIEWED
MLLLELNILTLNIWGIPYVSSDRRPRIDAICKELASGKYDIVSLQEVWAQEDSELLQKGTEAVLPHSHYFHSGVMGAGLLVLSKYPILGTLFHAWSVNGYFHRIQHADWFGGKGVGLCRILVGGQMVHLYNAHLHAEYDNANDEYKTHRVIQAFDTAQFIEATRGNSALQILAGDLNAQPQDISYKVLLYTSKMLDSCDSDSFRTNECEHNSYTSKQARERNPLGIRIDHIFVRGGDHVNAEIAEYKLPFPERVPGEKFSFSDHEAVMAKLKLFKLEPRSEEPVATIEVNCLVEDGETCSVREVGAGDALTGEDDQSSQHQPEIQCNGSSTSIQSMPAARTAALLEALALCDASLLQLNTDRILYYSAATFLFVLLVLLVEFTAPVGMRTIFLLLKFIVFGVILFCVFMASIWNYMERNGVLQGKKSMEVMLHHAQKYEYFY

Gene Information

Entrez Gene ID
38396
Gene Name
CG12034 gene product from transcript CG12034-RA
Gene Symbol
CG12034
Species
Drosophila melanogaster

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0046872 IEA:UniProtKB-KW F metal ion binding
GO:0004767 IEA:UniProtKB-EC F sphingomyelin phosphodiesterase activity
GO:0006665 IEA:UniProtKB-UniPathway P sphingolipid metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
dme01100 Metabolic pathways
dme00600 Sphingolipid metabolism

REACTOME Pathway Links

REACTOME Pathway ID Description
6226897 Glycosphingolipid metabolism
6226702 Sphingolipid metabolism

Domain Information

InterPro Annotations

Accession Description
IPR005135 Endonuclease/exonuclease/phosphatase

UniProt Annotations

Entry Information

Gene Name
CG12034 gene product from transcript CG12034-RA
Protein Entry
NSMA_DROME
UniProt ID
Q9VZS6
Species
Drosophila

Comments

Comment Type Description
Catalytic Activity Sphingomyelin + H(2)O = N-acylsphingosine + phosphocholine.
Interaction Q7JV09:jp; NbExp=1; IntAct=EBI-125601, EBI-141560; Q9V447:Kr-h2; NbExp=1; IntAct=EBI-125601, EBI-135893;
Pathway Lipid metabolism; sphingolipid metabolism.
Similarity Belongs to the neutral sphingomyelinase family. {ECO:0000305}.
Subcellular Location Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.

Identical and Related Proteins

Unique RefSeq proteins for LMP009156 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
21357231 RefSeq NP_647790 442 CG12034

Identical Sequences to LMP009156 proteins

Reference Database Accession Length Protein Name
GI:21357231 GenBank AAK93138.1 442 LD24865p [Drosophila melanogaster]
GI:21357231 GenBank ACL85016.1 442 CG12034-PA, partial [synthetic construct]
GI:21357231 GenBank ACL89931.1 442 CG12034-PA [synthetic construct]
GI:21357231 gnl FlyBase 442 CG12034 [Drosophila melanogaster]
GI:21357231 SwissProt Q9VZS6.2 442 RecName: Full=Putative neutral sphingomyelinase [Drosophila melanogaster]

Related Sequences to LMP009156 proteins

Reference Database Accession Length Protein Name
GI:21357231 GenBank ACK57212.1 321 CG12034-like protein, partial [Drosophila affinis]
GI:21357231 GenBank JAB99762.1 451 Putative neutral sphingomyelinase, partial [Ceratitis capitata]
GI:21357231 GenBank JAD02310.1 417 hypothetical protein g.23281 [Bactrocera cucurbitae]
GI:21357231 gnl WGS:AADE 453 GA11353 [Drosophila pseudoobscura pseudoobscura]
GI:21357231 RefSeq XP_001352679.1 453 GA11353 [Drosophila pseudoobscura pseudoobscura]
GI:21357231 RefSeq XP_004526817.1 422 PREDICTED: putative neutral sphingomyelinase-like [Ceratitis capitata]