Gene/Proteome Database (LMPD)

LMPD ID
LMP009168
Gene ID
53445
Species
Drosophila melanogaster (Drosophila)
Gene Name
CG16988 gene product from transcript CG16988-RA
Gene Symbol
Roc1b
Synonyms
['BcDNA:AT21612', 'CG16988', 'Dmel\CG16988', 'dRoc1b', 'Roc', 'roc1b', 'ROC1b', 'ROC1B', 'ROC2']
Alternate Names
CG16988-PA; Roc1b; Roc1b-PA
Chromosome
3L
Map Location
61C1-61C1

Proteins

Roc1b
Refseq ID NP_652613
Protein GI 21358051
UniProt ID Q9NHX0
mRNA ID NM_144356
Length 122
RefSeq Status REVIEWED
MAEEIEVEETEDFHDMDFNDEEPSCSGGAVQARTERFVVKKWVAHAMWGWDVAVDNCAICRNHIMNLCIECQADPNANQDECTVAWGECNHAFHYHCIARWLKTRLVCPLDNKEWVYQKYGR

Gene Information

Entrez Gene ID
53445
Gene Name
CG16988 gene product from transcript CG16988-RA
Gene Symbol
Roc1b
Species
Drosophila melanogaster

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0019005 ISS:UniProtKB C SCF ubiquitin ligase complex
GO:0005737 IEA:UniProtKB-KW C cytoplasm
GO:0005634 ISS:UniProtKB C nucleus
GO:0004842 IDA:FlyBase F ubiquitin-protein transferase activity
GO:0008270 ISM:FlyBase F zinc ion binding
GO:0006919 IGI:FlyBase P activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0008283 ISS:UniProtKB P cell proliferation
GO:0019915 IDA:FlyBase P lipid storage
GO:0016567 IDA:FlyBase P protein ubiquitination
GO:0030317 IMP:FlyBase P sperm motility

KEGG Pathway Links

KEGG Pathway ID Description
dme04141 Protein processing in endoplasmic reticulum
dme04350 TGF-beta signaling pathway
dme04120 Ubiquitin mediated proteolysis
dme04310 Wnt signaling pathway

Domain Information

InterPro Annotations

Accession Description
IPR024766 Zinc finger, RING-H2-type
IPR001841 Zinc finger, RING-type
IPR013083 Zinc finger, RING/FYVE/PHD-type

UniProt Annotations

Entry Information

Gene Name
CG16988 gene product from transcript CG16988-RA
Protein Entry
RBX1B_DROME
UniProt ID
Q9NHX0
Species
Drosophila

Comments

Comment Type Description
Caution It is uncertain whether Met-1 or Met-16 is the initiator. {ECO:0000305}.
Domain The RING-type zinc finger domain is essential for ubiquitin ligase activity. It coordinates an additional third zinc ion (By similarity). {ECO:0000250}.
Function Component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate (By similarity). {ECO:0000250}.
Pathway Protein modification; protein ubiquitination.
Sequence Caution Sequence=AAF32313.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Similarity Belongs to the RING-box family. {ECO:0000305}.
Similarity Contains 1 RING-type zinc finger. {ECO:0000255|PROSITE-ProRule:PRU00175}.
Subcellular Location Cytoplasm. Nucleus.
Subunit Part of a SCF complex consisting of Skpa (SKP1), Lin19 (CUL1), Roc1B and a F-box protein. {ECO:0000250}.
Tissue Specificity Highly expressed in early embryos, and in pupae. Widely expressed in adult males, while it is weakly expressed in adult females. {ECO:0000269|PubMed:12062088}.

Identical and Related Proteins

Unique RefSeq proteins for LMP009168 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
21358051 RefSeq NP_652613 122 Roc1b

Identical Sequences to LMP009168 proteins

Reference Database Accession Length Protein Name
GI:21358051 GenBank AAL48432.1 122 AT21612p [Drosophila melanogaster]
GI:21358051 GenBank ACL87431.1 122 Roc1b-PA, partial [synthetic construct]
GI:21358051 GenBank ACL91994.1 122 Roc1b-PA [synthetic construct]
GI:21358051 gnl FlyBase 122 Roc1b [Drosophila melanogaster]
GI:21358051 SwissProt Q9NHX0.2 122 RecName: Full=RING-box protein 1B; AltName: Full=Regulator of cullins 1b [Drosophila melanogaster]

Related Sequences to LMP009168 proteins

Reference Database Accession Length Protein Name
GI:21358051 GenBank AAF32313.1 107 ring finger protein ROC1B [Drosophila melanogaster]
GI:21358051 GenBank EDW17157.1 130 GI16738 [Drosophila mojavensis]
GI:21358051 GenBank EDW68806.1 131 GJ12485 [Drosophila virilis]
GI:21358051 RefSeq XP_001983644.1 128 GH15458 [Drosophila grimshawi]
GI:21358051 RefSeq XP_002012026.1 130 GI16738 [Drosophila mojavensis]
GI:21358051 RefSeq XP_002046464.1 131 GJ12485 [Drosophila virilis]