Gene/Proteome Database (LMPD)

LMPD ID
LMP009172
Gene ID
31245
Species
Drosophila melanogaster (Drosophila)
Gene Name
CG9904 gene product from transcript CG9904-RA
Gene Symbol
Seipin
Synonyms
CG9904; Dmel\CG9904; dSeipin; EG:BACR7C10.1
Chromosome
X
Map Location
3A7-3A8

Proteins

seipin
Refseq ID NP_570012
Protein GI 20128943
UniProt ID Q9V3X4
mRNA ID NM_130656
Length 370
RefSeq Status REVIEWED
MNILLRLIVFALDPLGLGRRFLIRPAVNLGWNVYDRVRSKADEKVGTVRELVLRLGLIAFAVVLIIWLAVFMYAAFYYVYMPAISHTRPVHMQFKTCLETSTPCTFPHAHVSLTKKQQLLMVGQAYKVIVNIDMPESPQNLELGMFMVCAEMRDYDSMLRGHSCRSAMMRYRSPLIRMISTWVLSPLYVLGWKEEFQQVPVEIFSRYLEERQHPITDVYVEIQSQKIQFYTVTLHIVADFTGLRYIMFNWPVLSAIVAISTNLFFILVVFLLSWYHWSDAKWLHSVQIKYARLTKSLEPGVIHSKASSLRDDDDDLVAYSDKSDIADVGGDTLSDVDADDLVLVKKSRSGKRESPDALRKRPTKKTTADH

Gene Information

Entrez Gene ID
31245
Gene Name
CG9904 gene product from transcript CG9904-RA
Gene Symbol
Seipin
Species
Drosophila melanogaster

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IDA:FlyBase C endoplasmic reticulum
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0046339 IMP:FlyBase P diacylglycerol metabolic process
GO:0032469 IMP:FlyBase P endoplasmic reticulum calcium ion homeostasis
GO:0006635 IMP:FlyBase P fatty acid beta-oxidation
GO:0008610 IMP:FlyBase P lipid biosynthetic process
GO:0046473 IMP:FlyBase P phosphatidic acid metabolic process
GO:0010884 IMP:FlyBase P positive regulation of lipid storage
GO:0046890 IMP:FlyBase P regulation of lipid biosynthetic process
GO:0010883 IMP:FlyBase P regulation of lipid storage
GO:0090207 IMP:FlyBase P regulation of triglyceride metabolic process
GO:0042594 IMP:FlyBase P response to starvation

Domain Information

InterPro Annotations

Accession Description
IPR009617 Adipose-regulatory protein, Seipin

UniProt Annotations

Entry Information

Gene Name
CG9904 gene product from transcript CG9904-RA
Protein Entry
Q9V3X4_DROME
UniProt ID
Q9V3X4
Species
Drosophila

Comments

Comment Type Description
Developmental Stage At late embryonic stages, highly expressed in hindgut. At larval stages, expression detected in fat body, anterior midgut and salivary gland.
Disruption Phenotype Flies are viable and fertile with no noticeable behavior defects, but display reduced average weight. The size of the lipid droplets in larval fat bodies and the fat cells of young adults is significantly reduced, but exhibit ectopic lipid droplets in salivary gland and gut. Flies also display greatly reduced total glyceride levels and hypersensitivity to starvation.
Function Is a regulator of lipid catabolism essential for adipocyte differentiation. May also be involved in the central regulation of energy homeostasis (By similarity). Necessary for correct lipid storage and lipid droplets maintenance; plays a tissue-autonomous role in controlling lipid storage in adipocytes and in preventing ectopic lipid droplet formation in non-adipose tissues. May participate in phosphatidic acid metabolism and subsequently down-regulate lipogenesis.
Subcellular Location Endoplasmic reticulum membrane ; Multi-pass membrane protein {ECO:0000255, ECO:0000269|PubMed:21533227}.
Tissue Specificity Widely expressed, with highest levels detected in fat body, moderate levels detected in salivary gland, midgut and muscle, and weak expression detected in brain.

Identical and Related Proteins

Unique RefSeq proteins for LMP009172 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
20128943 RefSeq NP_570012 370 seipin

Identical Sequences to LMP009172 proteins

Reference Database Accession Length Protein Name
GI:20128943 EMBL CAB65856.1 370 EG:BACR7C10.1 [Drosophila melanogaster]
GI:20128943 GenBank AAM51042.1 370 SD04409p [Drosophila melanogaster]
GI:20128943 GenBank ACL87673.1 370 CG9904-PA, partial [synthetic construct]
GI:20128943 GenBank ACL92155.1 370 CG9904-PA [synthetic construct]
GI:20128943 gnl FlyBase 370 seipin [Drosophila melanogaster]
GI:20128943 SwissProt Q9V3X4.1 370 RecName: Full=Seipin; Flags: Precursor [Drosophila melanogaster]

Related Sequences to LMP009172 proteins

Reference Database Accession Length Protein Name
GI:20128943 GenBank EDV45642.1 369 GG12941 [Drosophila erecta]
GI:20128943 GenBank EDW44004.1 346 GM19233 [Drosophila sechellia]
GI:20128943 gnl WGS:AADE 368 GA22113 [Drosophila pseudoobscura pseudoobscura]
GI:20128943 RefSeq XP_001982673.1 369 GG12941 [Drosophila erecta]
GI:20128943 RefSeq XP_002040533.1 346 GM19233 [Drosophila sechellia]
GI:20128943 RefSeq XP_001355569.2 368 GA22113 [Drosophila pseudoobscura pseudoobscura]