Gene/Proteome Database (LMPD)

LMPD ID
LMP009177
Gene ID
38823
Species
Drosophila melanogaster (Drosophila)
Gene Name
CG32380 gene product from transcript CG32380-RA
Gene Symbol
SMSr
Synonyms
CG32380; CG8572; CG8576; Css3beta; Dmel\CG32380; dmSMSr; dSMSr
Chromosome
3L
Map Location
65F7-65F9

Proteins

SMSr
Refseq ID NP_648114
Protein GI 21356655
UniProt ID Q9VS60
mRNA ID NM_139857
Length 600
RefSeq Status REVIEWED
MCDGEIGDPVTQPRSEGGGLVTMDQETRTHYLDAATDKHLTNGSPDPEPVDPLLVAQWSIENVTSWATCMEHFSRTLLDCLRQEAIDGEVLLSLTEEDVRDMRYKLGYKLTFGELKKFWIAVLKLQLLVKNSSAESVILGIECHGNGNSVYMPLASTGCGPPSSSTCPCPQAECPSYVSDCDTYLRMGGRYVPPEYFKTAMSLGYSFVVTWITSLTMVIVHERVPDMKRYPPLPDIFLDNVPHIPWAFNMCEITGSLLFTIWVVVLTFHKYRLVLLRRFFALAGTVFLLRCVTMLITSLSVPGTHLQCSQKDFAIDDPNVDMVGALIIRMSRAYRIWSGLGMSIQGVRTCGDYMFSGHTVALTLLNFFITEYTPRNLYFLHTLTWLLNMFGIFFILAAHEHYSIDVFVAFYITSRLFLYYHTLANNRALMQSDSKRTRVWFPMFSYFESSVDGMVPNEYDTLGSLIDGIIEQIFKAKDQLAISVKRCWLDAPLSGNSSAHMFGGESEQCLRNGTASAAFFSPHQSLIGGLGGQRSQTHLNSAQSGSSTPTPATSAPTKSLPTQKKTFRDASVDPFSRTTFAAVQQAENVKDSPMKEKKHL

Gene Information

Entrez Gene ID
38823
Gene Name
CG32380 gene product from transcript CG32380-RA
Gene Symbol
SMSr
Species
Drosophila melanogaster

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0030176 IDA:UniProtKB C integral component of endoplasmic reticulum membrane
GO:0016021 NAS:UniProtKB C integral component of membrane
GO:0047493 IDA:UniProtKB F ceramide cholinephosphotransferase activity
GO:0033188 IDA:UniProtKB F sphingomyelin synthase activity
GO:0046513 IDA:UniProtKB P ceramide biosynthetic process
GO:0007030 IMP:FlyBase P Golgi organization
GO:0060305 IMP:FlyBase P regulation of cell diameter
GO:2000303 IDA:UniProtKB P regulation of ceramide biosynthetic process
GO:0006686 NAS:UniProtKB P sphingomyelin biosynthetic process

Domain Information

InterPro Annotations

Accession Description
IPR025749 Sphingomyelin synthase-like domain
IPR001660 Sterile alpha motif domain
IPR013761 Sterile alpha motif/pointed domain

UniProt Annotations

Entry Information

Gene Name
CG32380 gene product from transcript CG32380-RA
Protein Entry
Q9VS60_DROME
UniProt ID
Q9VS60
Species
Drosophila

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=A ; IsoId=Q9VS60-1; Sequence=Displayed; Note=No experimental confirmation available. ; Name=B ; IsoId=Q9VS60-2; Sequence=VSP_050675; Note=No experimental confirmation available. ;
Domain The SAM domain is required to retain SMSR in the endoplasmic reticulum.
Function Sphingomyelin synthases synthesize sphingolipids through transfer of a phosphatidyl head group on to the primary hydroxyl of ceramide. SAMD8 is an endoplasmic reticulum (ER) transferase that has no sphingomyelin synthase activity but can convert phosphatidylethanolamine (PE) and ceramide to ceramide phosphoethanolamine (CPE) albeit with low product yield. Appears to operate as a ceramide sensor to control ceramide homeostasis in the endoplasmic reticulum rather than a converter of ceramides. Seems to be critical for the integrity of the early secretory pathway.
Similarity Belongs to the sphingomyelin synthase family.
Similarity Contains 1 SAM (sterile alpha motif) domain.
Subcellular Location Endoplasmic reticulum membrane ; Multi-pass membrane protein .

Identical and Related Proteins

Unique RefSeq proteins for LMP009177 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
21356655 RefSeq NP_648114 600 SMSr

Identical Sequences to LMP009177 proteins

Reference Database Accession Length Protein Name
GI:21356655 GenBank AAK93029.1 600 GH24627p [Drosophila melanogaster]
GI:21356655 GenBank ACL85413.1 600 SMSr-PA, partial [synthetic construct]
GI:21356655 GenBank ACL90262.1 600 SMSr-PA [synthetic construct]
GI:21356655 gnl FlyBase 600 SMSr [Drosophila melanogaster]
GI:21356655 SwissProt Q9VS60.2 600 RecName: Full=Sphingomyelin synthase-related 1; AltName: Full=Ceramide phosphoethanolamine synthase; Short=CPE synthase [Drosophila melanogaster]

Related Sequences to LMP009177 proteins

Reference Database Accession Length Protein Name
GI:21356655 GenBank EDV50483.1 590 GG14968 [Drosophila erecta]
GI:21356655 GenBank EDW50831.1 601 GM13763 [Drosophila sechellia]
GI:21356655 GenBank EDW93749.1 590 GE20416 [Drosophila yakuba]
GI:21356655 RefSeq XP_001971457.1 590 GG14968 [Drosophila erecta]
GI:21356655 RefSeq XP_002035695.1 601 GM13763 [Drosophila sechellia]
GI:21356655 RefSeq XP_002094037.1 590 GE20416 [Drosophila yakuba]