Gene/Proteome Database (LMPD)

LMPD ID
LMP009178
Gene ID
46059
Species
Drosophila melanogaster (Drosophila)
Gene Name
Sphingosine-1-phosphate lyase
Gene Symbol
Sply
Synonyms
anon-WO0142479.5; CG8946; Dmel\CG8946; l(2)05091; spl; Spl; SPL; sply
Alternate Names
CG8946-PA; CG8946-PB; Sphingosine-1-phosphate lyase; Sply-PA; Sply-PB; sphinganine-1-phosphate lyase; sphingosine-1-phosphate lyase
Chromosome
2R
Map Location
53F6-53F7
EC Number
4.1.2.27

Proteins

Sphingosine-1-phosphate lyase, isoform A
Refseq ID NP_652032
Protein GI 21355963
UniProt ID Q9V7Y2
mRNA ID NM_143775
Length 545
RefSeq Status REVIEWED
MRPFSGSDCLKPVTEGINRAFGAKEPWQVATITATTVLGGVWLWTVICQDENLYIRGKRQFFKFAKKIPAVRRQVETELAKAKNDFETEIKKSNAHLTYSETLPEKGLSKEEILRLVDEHLKTGHYNWRDGRVSGAVYGYKPDLVELVTEVYGKASYTNPLHADLFPGVCKMEAEVVRMACNLFHGNSASCGTMTTGGTESIVMAMKAYRDFAREYKGITRPNIVVPKTVHAAFDKGGQYFNIHVRSVDVDPETYEVDIKKFKRAINRNTILLVGSAPNFPYGTIDDIEAIAALGVKYDIPVHVDACLGSFVVALVRNAGYKLRPFDFEVKGVTSISADTHKYGFAPKGSSVILYSDKKYKDHQFTVTTDWPGGVYGSPTVNGSRAGGIIAACWATMMSFGYDGYLEATKRIVDTARYIERGVRDIDGIFIFGKPATSVIALGSNVFDIFRLSDSLCKLGWNLNALQFPSGIHLCVTDMHTQPGVADKFIADVRSCTAEIMKDPGQPVVGKMALYGMAQSIPDRSVIGEVTRLFLHSMYYTPSQK
Sphingosine-1-phosphate lyase, isoform B
Refseq ID NP_725652
Protein GI 24654344
UniProt ID Q9V7Y2
mRNA ID NM_166215
Length 545
RefSeq Status REVIEWED
Protein sequence is identical to GI:21355963 (mRNA isoform)

Gene Information

Entrez Gene ID
46059
Gene Name
Sphingosine-1-phosphate lyase
Gene Symbol
Sply
Species
Drosophila melanogaster

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IEA:UniProtKB-KW C endoplasmic reticulum
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0016831 IEA:InterPro F carboxy-lyase activity
GO:0030170 IEA:InterPro F pyridoxal phosphate binding
GO:0008117 IDA:FlyBase F sphinganine-1-phosphate aldolase activity
GO:0019752 IEA:InterPro P carboxylic acid metabolic process
GO:0046331 IMP:FlyBase P lateral inhibition
GO:0007275 IEA:UniProtKB-KW P multicellular organismal development
GO:0030149 IMP:FlyBase P sphingolipid catabolic process

KEGG Pathway Links

KEGG Pathway ID Description
dme01100 Metabolic pathways
dme00600 Sphingolipid metabolism
dme_M00100 Sphingosine degradation

REACTOME Pathway Links

REACTOME Pathway ID Description
6226701 Sphingolipid de novo biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR002129 Pyridoxal phosphate-dependent decarboxylase
IPR015424 Pyridoxal phosphate-dependent transferase
IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1

UniProt Annotations

Entry Information

Gene Name
Sphingosine-1-phosphate lyase
Protein Entry
SGPL_DROME
UniProt ID
Q9V7Y2
Species
Drosophila

Comments

Comment Type Description
Catalytic Activity Sphinganine 1-phosphate = phosphoethanolamine + palmitaldehyde.
Cofactor Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; Evidence={ECO:0000250};
Developmental Stage Expressed both maternally and zygotically. Expression is high in early and late embryos, and then again early in metamorphosis, followed by reduction to basal levels after eclosion of adult flies in both males and females. {ECO:0000269|PubMed:12702658}.
Function Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Sphingolipid catabolism is required for normal development including viability, reproduction and muscle development. {ECO:0000269|PubMed:12702658}.
Pathway Lipid metabolism; sphingolipid metabolism.
Similarity Belongs to the group II decarboxylase family. Sphingosine-1-phosphate lyase subfamily. {ECO:0000305}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}.
Tissue Specificity Localized to the developing gut primordium during embryogenesis. {ECO:0000269|PubMed:12702658}.

Identical and Related Proteins

Unique RefSeq proteins for LMP009178 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
21355963 RefSeq NP_652032 545 Sphingosine-1-phosphate lyase, isoform A

Identical Sequences to LMP009178 proteins

Reference Database Accession Length Protein Name
GI:21355963 GenBank ABL48152.1 545 Sequence 975 from patent US 7135558
GI:21355963 GenBank ABW46742.1 545 Sequence 16 from patent US 7262044
GI:21355963 GenBank ACL85818.1 545 Sply-PA, partial [synthetic construct]
GI:21355963 GenBank ACL90639.1 545 Sply-PA [synthetic construct]
GI:21355963 GenBank ADF21397.1 545 Sequence 16 from patent US 7674580
GI:21355963 GenBank AEK15393.1 545 Sequence 16 from patent US 7973143

Related Sequences to LMP009178 proteins

Reference Database Accession Length Protein Name
GI:21355963 GenBank EDW48244.1 545 GM20006 [Drosophila sechellia]
GI:21355963 GenBank EDW92191.1 545 GE14215 [Drosophila yakuba]
GI:21355963 GenBank EDX07450.1 545 GD25496 [Drosophila simulans]
GI:21355963 RefSeq XP_002034231.1 545 GM20006 [Drosophila sechellia]
GI:21355963 RefSeq XP_002092479.1 545 GE14215 [Drosophila yakuba]
GI:21355963 RefSeq XP_002081865.1 545 GD25496 [Drosophila simulans]