Gene/Proteome Database (LMPD)

LMPD ID
LMP009181
Gene ID
33473
Species
Drosophila melanogaster (Drosophila)
Gene Name
Synaptotagmin 1
Gene Symbol
Syt1
Synonyms
CG3139; D. Syt I; Dmel\CG3139; Droso1; DSypt; dSYT; DSyt; DSYT; dsyt1; Dsyt2; DSYT2; dsytI; l(2)23AB1; l(2)23Ba; l(2)k05909; STY1; syt; Syt; SYT; syt 1; Syt 1; syt I; Syt I; SYT I; syt-1; Syt-1; syt1; SYT1; sytI; SytI
Chromosome
2L
Map Location
23A5-23B1

Proteins

synaptotagmin 1, isoform A
Refseq ID NP_523460
Protein GI 24581230
UniProt ID P21521
mRNA ID NM_078736
Length 474
RefSeq Status REVIEWED
MPPNAKSETDAKPEAEPAPASEPAADLESVDQKLEETHHSKFREVDRQEQEVLAEKAAEAASQRIAQVESTTRSATTEAQESTTTAVPVIKKIEHVGEVVTEVIAERTGLPTWGVVAIIILVFLVVFGIIFFCVRRFLKKRRTKDGKGKKGVDMKSVQLLGSAYKEKVQPDMEELTENAEEGDEEDKQSEQKLGRLNFKLEYDFNSNSLAVTVIQAEELPALDMGGTSDPYVKVYLLPDKKKKFETKVHRKTLSPVFNETFTFKSLPYADAMNKTLVFAIFDFDRFSKHDQIGEVKVPLCTIDLAQTIEEWRDLVSVEGEGGQEKLGDICFSLRYVPTAGKLTVVILEAKNLKKMDVGGLSDPYVKIAIMQNGKRLKKKKTSIKKCTLNPYYNESFSFEVPFEQIQKICLVVTVVDYDRIGTSEPIGRCILGCMGTGTELRHWSDMLASPRRPIAQWHTLKDPEETDEILKNMK
synaptotagmin 1, isoform B
Refseq ID NP_722838
Protein GI 24581226
UniProt ID X2J4C1
mRNA ID NM_164501
Length 472
RefSeq Status REVIEWED
Protein sequence is identical to GI:665404136 (mRNA isoform)
synaptotagmin 1, isoform C
Refseq ID NP_722839
Protein GI 24581228
UniProt ID X2J4C1
mRNA ID NM_164502
Length 472
RefSeq Status REVIEWED
Protein sequence is identical to GI:665404136 (mRNA isoform)
synaptotagmin 1, isoform E
Refseq ID NP_995619
Protein GI 442625570
UniProt ID P21521
mRNA ID NM_205897
Length 472
RefSeq Status REVIEWED
MPPNAKSETDAKPEAEPAPASEPAADLESVDQKLEETHHSKFREVDRQEQEVLAEKAAEAASQRIAQVESTTRSATTEAQESTTTAVPVIKKIEHVGEVVTEVIAERTGLPTWGVVAIIILVFLVVFGIIFFCVRRFLKKRRTKDGKGKKGVDMKSVQLLGSAYKEKVQPDMEELTENAEEGDEEDKQSEQKLGRLNFKLEYDFNSNSLAVTVIQAEELPALDMGGTSDPYVKVYLLPDKKKKFETKVHRKTLSPVFNETFTFKSLPYADAMNKTLVFAIFDFDRFSKHDQIGEVKVPLCTIDLAQTIEEWRDLVSVEGEGGQLGDICFSLRYVPTAGKLTVVILEAKNLKKMDVGGLSDPYVKIAIMQNGKRLKKKKTSIKKCTLNPYYNESFSFEVPFEQIQKICLVVTVVDYDRIGTSEPIGRCILGCMGTGTELRHWSDMLASPRRPIAQWHTLKDPEETDEILKNMK
synaptotagmin 1, isoform F
Refseq ID NP_001259965
Protein GI 442625572
UniProt ID P21521
mRNA ID NM_001273036
Length 170
RefSeq Status REVIEWED
MPPNAKSETDAKPEAEPAPASEPAADLESVDQKLEETHHSKFREVDRQEQEVLAEKAAEAASQRIAQVESTTRSATTEAQESTTTAVPVIKKIEHVGEVVTEVIAERTGLPTWGVVAIIILVFLVVFGIIFFCVRRFLKKRRTKDGKGKKGVDMKSVQLLGSAYKEKVSV
synaptotagmin 1, isoform G
Refseq ID NP_001259966
Protein GI 442625574
UniProt ID P21521
mRNA ID NM_001273037
Length 331
RefSeq Status REVIEWED
MPPNAKSETDAKPEAEPAPASEPAADLESVDQKLEETHHSKFREVDRQEQEVLAEKAAEAASQRIAQVESTTRSATTEAQESTTTAVPVIKKIEHVGEVVTEVIAERTGLPTWGVVAIIILVFLVVFGIIFFCVRRFLKKRRTKDGKGKKGVDMKSVQLLGSAYKEKVQPDMEELTENAEEGDEEDKQSEQKLGRLNFKLEYDFNSNSLAVTVIQAEELPALDMGGTSDPYVKVYLLPDKKKKFETKVHRKTLSPVFNETFTFKSLPYADAMNKTLVFAIFDFDRFSKHDQIGEVKVPLCTIDLAQTIEEWRDLVSVEGEGGQVVLREVNI
synaptotagmin 1, isoform H
Refseq ID NP_001285567
Protein GI 665404134
UniProt ID X2J979
mRNA ID NM_001298638
Length 473
RefSeq Status REVIEWED
MPPNAKSETDAKPEAEPAPASEPAADLESVDQKLEETHHSKFREVDRQEQEVLAEKAAEAASQRIAQVESTTRSATTEAQESTTTAVPVIKKIEHVGEVVTEVIAERTGLPTWGVVAIIILVFLVVFGIIFFCVRRFLKKRRTKDGKGKKGVDMKSVQLLGSAYKEKVQPDMEELTENAEEGDEEDKQSEQKLGRLNFKLEYDFNSNSLAVTVIQAEELPALDMGGTSDPYVKVYLLPDKKKKFETKVHRKTLSPVFNETFTFKSLPYADAMNKTLVFAIFDFDRFSKHDQIGEVKVPLCTIDLAQTIEEWRDLVSVEGEGGQKLGDICFSLRYVPTAGKLTVVILEAKNLKKMDVGGLSDPYVKIAIMQNGKRLKKKKTSIKKCTLNPYYNESFSFEVPFEQIQKICLVVTVVDYDRIGTSEPIGRCILGCMGTGTELRHWSDMLASPRRPIAQWHTLKDPEETDEILKNMK
synaptotagmin 1, isoform I
Refseq ID NP_001285568
Protein GI 665404136
UniProt ID X2J4C1
mRNA ID NM_001298639
Length 472
RefSeq Status REVIEWED
MPPNAKSETDAKPEAEPAPASEPAADLESVDQKLEETHHSKFREVDRQEQEVLAEKAAEAASQRIAQVESTTRSATTEAQESTTTAVPVIKKIEHVGEVVTEVIAERTGLPTWGVVAIIILVFLVVFGIIFFCVRRFLKKRRTKDGKGKKGVDMKSVQLLGSAYKEKPDMEELTENAEEGDEEDKQSEQKLGRLNFKLEYDFNSNSLAVTVIQAEELPALDMGGTSDPYVKVYLLPDKKKKFETKVHRKTLSPVFNETFTFKSLPYADAMNKTLVFAIFDFDRFSKHDQIGEVKVPLCTIDLAQTIEEWRDLVSVEGEGGQEKLGDICFSLRYVPTAGKLTVVILEAKNLKKMDVGGLSDPYVKIAIMQNGKRLKKKKTSIKKCTLNPYYNESFSFEVPFEQIQKICLVVTVVDYDRIGTSEPIGRCILGCMGTGTELRHWSDMLASPRRPIAQWHTLKDPEETDEILKNMK

Gene Information

Entrez Gene ID
33473
Gene Name
Synaptotagmin 1
Gene Symbol
Syt1
Species
Drosophila melanogaster

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0030054 IEA:UniProtKB-KW C cell junction
GO:0030285 NAS:FlyBase C integral component of synaptic vesicle membrane
GO:0031594 IDA:FlyBase C neuromuscular junction
GO:0008021 IDA:FlyBase C synaptic vesicle
GO:0043195 IDA:FlyBase C terminal bouton
GO:0005544 IDA:FlyBase F calcium-dependent phospholipid binding
GO:0005509 IDA:FlyBase F calcium ion binding
GO:0001786 IDA:FlyBase F phosphatidylserine binding
GO:0042803 IDA:FlyBase F protein homodimerization activity
GO:0000149 IPI:FlyBase F SNARE binding
GO:0005215 IEA:InterPro F transporter activity
GO:0048791 IMP:FlyBase P calcium ion-dependent exocytosis of neurotransmitter
GO:0008345 IMP:FlyBase P larval locomotory behavior
GO:0007269 IMP:FlyBase P neurotransmitter secretion
GO:0031340 IDA:FlyBase P positive regulation of vesicle fusion
GO:1900073 IMP:FlyBase P regulation of neuromuscular synaptic transmission
GO:0007317 IMP:FlyBase P regulation of pole plasm oskar mRNA localization
GO:0050803 IMP:FlyBase P regulation of synapse structure and activity
GO:0060024 IDA:FlyBase P rhythmic synaptic transmission
GO:0007268 IDA:FlyBase P synaptic transmission
GO:0048488 IDA:FlyBase P synaptic vesicle endocytosis
GO:0016079 ISS:FlyBase P synaptic vesicle exocytosis
GO:0016192 IMP:FlyBase P vesicle-mediated transport

REACTOME Pathway Links

REACTOME Pathway ID Description
6226572 Acetylcholine Neurotransmitter Release Cycle
6225910 Glutamate Neurotransmitter Release Cycle
6225909 Neuronal System
6225911 Neurotransmitter Release Cycle
6225908 Transmission across Chemical Synapses

Domain Information

InterPro Annotations

Accession Description
IPR000008 C2 domain
IPR001565 Synaptotagmin
IPR015428 Synaptotagmin 1

UniProt Annotations

Entry Information

Gene Name
Synaptotagmin 1
Protein Entry
SY65_DROME
UniProt ID
X2J979
Species
Drosophila

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=5; Name=A; IsoId=P21521-1; Sequence=Displayed; Name=B; Synonyms=C, I; IsoId=P21521-2; Sequence=VSP_011862; Note=No experimental confirmation available.; Name=E; IsoId=P21521-4; Sequence=VSP_054631; Note=No experimental confirmation available.; Name=G; IsoId=P21521-5; Sequence=VSP_054630, VSP_054632; Note=No experimental confirmation available.; Name=F; IsoId=P21521-6; Sequence=VSP_054628, VSP_054629; Note=No experimental confirmation available.;
Cofactor Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000250}; Note=Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domains. {ECO:0000250};
Function May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. {ECO:0000269|PubMed:1840599}.
Interaction Q24211:stnA; NbExp=2; IntAct=EBI-484504, EBI-604915; Q24212:stnB; NbExp=5; IntAct=EBI-484504, EBI-604879;
Rna Editing Modified_positions=367 {ECO:0000269|PubMed:12907802, ECO:0000269|Ref.4}, 379 {ECO:0000269|PubMed:12907802}, 383 {ECO:0000269|PubMed:10731132, ECO:0000269|PubMed:12907802}, 405 {ECO:0000269|PubMed:10731132, ECO:0000269|PubMed:12907802}; Note=Partially edited.;
Sequence Caution Sequence=AAM50109.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=AAM50109.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
Similarity Belongs to the synaptotagmin family. {ECO:0000305}.
Similarity Contains 2 C2 domains. {ECO:0000255|PROSITE- ProRule:PRU00041}.
Subcellular Location Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000269|PubMed:1840599}; Single- pass membrane protein {ECO:0000269|PubMed:1840599}. Cell junction, synapse {ECO:0000269|PubMed:1840599}. Note=Synaptic vesicles in neurons.
Subunit Homodimer or homotrimer (Potential). Interacts with StnA and StnB via its second C2 domain. This interaction may mediate its retrieval from the plasma membrane, thereby facilitating the internalization of multiple synaptic vesicles from the plasma membrane. {ECO:0000269|PubMed:11069931, ECO:0000305}.

Identical and Related Proteins

Unique RefSeq proteins for LMP009181 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
24581230 RefSeq NP_523460 474 synaptotagmin 1, isoform A
442625570 RefSeq NP_995619 472 synaptotagmin 1, isoform E
442625572 RefSeq NP_001259965 170 synaptotagmin 1, isoform F
442625574 RefSeq NP_001259966 331 synaptotagmin 1, isoform G
665404134 RefSeq NP_001285567 473 synaptotagmin 1, isoform H
665404136 RefSeq NP_001285568 472 synaptotagmin 1, isoform I

Identical Sequences to LMP009181 proteins

Reference Database Accession Length Protein Name
GI:24581230 gnl FlyBase 474 synaptotagmin 1, isoform A [Drosophila melanogaster]
GI:665404136 gnl FlyBase 472 synaptotagmin 1, isoform B [Drosophila melanogaster]
GI:665404136 gnl FlyBase 472 synaptotagmin 1, isoform C [Drosophila melanogaster]
GI:442625570 gnl FlyBase 472 synaptotagmin 1, isoform E [Drosophila melanogaster]
GI:442625572 gnl FlyBase 170 synaptotagmin 1, isoform F [Drosophila melanogaster]
GI:442625574 gnl FlyBase 331 synaptotagmin 1, isoform G [Drosophila melanogaster]
GI:665404134 gnl FlyBase 473 synaptotagmin 1, isoform H [Drosophila melanogaster]
GI:665404136 gnl FlyBase 472 synaptotagmin 1, isoform I [Drosophila melanogaster]
GI:665404136 RefSeq NP_722838.1 472 synaptotagmin 1, isoform B [Drosophila melanogaster]
GI:665404136 RefSeq NP_722839.1 472 synaptotagmin 1, isoform C [Drosophila melanogaster]
GI:24581230 SwissProt P21521.3 474 RecName: Full=Synaptotagmin 1; AltName: Full=p65 [Drosophila melanogaster]

Related Sequences to LMP009181 proteins

Reference Database Accession Length Protein Name
GI:24581230 GenBank AAA28925.1 474 synaptotagmin p65 [Drosophila melanogaster]
GI:665404136 GenBank AAO42662.1 472 GH14933p [Drosophila melanogaster]
GI:665404136 GenBank EDW54050.1 474 GM18197 [Drosophila sechellia]
GI:24581230 GenBank EDW54050.1 474 GM18197 [Drosophila sechellia]
GI:24581230 GenBank EDX03524.1 474 GD22802 [Drosophila simulans]
GI:442625572 gnl FlyBase 474 synaptotagmin 1, isoform A [Drosophila melanogaster]
GI:665404134 gnl FlyBase 474 synaptotagmin 1, isoform A [Drosophila melanogaster]
GI:442625570 gnl FlyBase 474 synaptotagmin 1, isoform A [Drosophila melanogaster]
GI:442625574 gnl FlyBase 474 synaptotagmin 1, isoform A [Drosophila melanogaster]
GI:665404136 gnl FlyBase 474 synaptotagmin 1, isoform A [Drosophila melanogaster]
GI:442625574 gnl FlyBase 472 synaptotagmin 1, isoform E [Drosophila melanogaster]
GI:442625572 gnl FlyBase 472 synaptotagmin 1, isoform E [Drosophila melanogaster]
GI:665404134 gnl FlyBase 472 synaptotagmin 1, isoform E [Drosophila melanogaster]
GI:442625572 gnl FlyBase 331 synaptotagmin 1, isoform G [Drosophila melanogaster]
GI:442625570 gnl FlyBase 473 synaptotagmin 1, isoform H [Drosophila melanogaster]
GI:442625574 gnl FlyBase 473 synaptotagmin 1, isoform H [Drosophila melanogaster]
GI:665404136 RefSeq NP_523460.2 474 synaptotagmin 1, isoform A [Drosophila melanogaster]
GI:442625574 RefSeq NP_523460.2 474 synaptotagmin 1, isoform A [Drosophila melanogaster]
GI:442625572 RefSeq NP_523460.2 474 synaptotagmin 1, isoform A [Drosophila melanogaster]
GI:442625570 RefSeq NP_523460.2 474 synaptotagmin 1, isoform A [Drosophila melanogaster]
GI:665404134 RefSeq NP_523460.2 474 synaptotagmin 1, isoform A [Drosophila melanogaster]
GI:24581230 RefSeq XP_002037632.1 474 GM18197 [Drosophila sechellia]
GI:24581230 RefSeq XP_002087728.1 474 GE15027 [Drosophila yakuba]
GI:665404136 RefSeq XP_002077939.1 474 GD22802 [Drosophila simulans]
GI:24581230 RefSeq XP_002077939.1 474 GD22802 [Drosophila simulans]
GI:442625570 RefSeq XP_002077939.1 474 GD22802 [Drosophila simulans]
GI:665404134 RefSeq XP_002077939.1 474 GD22802 [Drosophila simulans]
GI:665404134 RefSeq NP_995619.2 472 synaptotagmin 1, isoform E [Drosophila melanogaster]
GI:442625574 RefSeq NP_995619.2 472 synaptotagmin 1, isoform E [Drosophila melanogaster]
GI:442625572 RefSeq NP_995619.2 472 synaptotagmin 1, isoform E [Drosophila melanogaster]
GI:442625570 RefSeq NP_001285567.1 473 synaptotagmin 1, isoform H [Drosophila melanogaster]
GI:442625572 SwissProt P21521.3 474 RecName: Full=Synaptotagmin 1; AltName: Full=p65 [Drosophila melanogaster]
GI:442625574 SwissProt P21521.3 474 RecName: Full=Synaptotagmin 1; AltName: Full=p65 [Drosophila melanogaster]
GI:665404136 SwissProt P21521.3 474 RecName: Full=Synaptotagmin 1; AltName: Full=p65 [Drosophila melanogaster]
GI:442625570 SwissProt P21521.3 474 RecName: Full=Synaptotagmin 1; AltName: Full=p65 [Drosophila melanogaster]
GI:665404134 SwissProt P21521.3 474 RecName: Full=Synaptotagmin 1; AltName: Full=p65 [Drosophila melanogaster]