Gene/Proteome Database (LMPD)

LMPD ID
LMP009639
Gene ID
835141
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
hydroxysteroid dehydrogenase 1
Gene Symbol
HSD1
Synonyms
hydroxysteroid dehydrogenase 1
Alternate Names
hydroxysteroid dehydrogenase 1
Chromosome
5
EC Number
1.1.1.146

Proteins

hydroxysteroid dehydrogenase 1
Refseq ID NP_680418
Protein GI 22327700
UniProt ID P0DKC6
mRNA ID NM_148113
Length 349
RefSeq Status REVIEWED
MELINDFLNLTAPFFTFFGLCFFLPPFYFFKFLQSIFSTIFSENLYGKVVLITGASSGIGEQLAYEYACRGACLALTARRKNRLEEVAEIARELGSPNVVTVHADVSKPDDCRRIVDDTITHFGRLDHLVNNAGMTQISMFENIEDITRTKAVLDTNFWGSVYTTRAALPYLRQSNGKIVAMSSSAAWLTAPRMSFYNASKAALLSFFETMRIELGGDVHITIVTPGYIESELTQGKYFSGEGELIVNQDMRDVQVGPFPVASASGCAKSIVNGVCRKQRYVTEPSWFKVTYLWKVLCPELIEWGCRLLYMTGTGMSEDTALNKRIMDIPGVRSTLYPESIRTPEIKSD

Gene Information

Entrez Gene ID
835141
Gene Name
hydroxysteroid dehydrogenase 1
Gene Symbol
HSD1
Species
Arabidopsis thaliana

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005811 IEA:UniProtKB-KW C lipid particle
GO:0070524 IEA:UniProtKB-EC F 11-beta-hydroxysteroid dehydrogenase (NADP+) activity
GO:0006694 IEA:UniProtKB-KW P steroid biosynthetic process

REACTOME Pathway Links

REACTOME Pathway ID Description
6254052 Glucocorticoid biosynthesis
6253653 Metabolism
6253725 Metabolism of lipids and lipoproteins
6254047 Metabolism of steroid hormones and vitamin D

Domain Information

InterPro Annotations

Accession Description
IPR002347 Glucose/ribitol dehydrogenase
IPR016040 NAD(P)-binding domain
IPR002198 Short-chain dehydrogenase/reductase SDR
IPR020904 Short-chain dehydrogenase/reductase, conserved site

UniProt Annotations

Entry Information

Gene Name
hydroxysteroid dehydrogenase 1
Protein Entry
HSD1A_ARATH
UniProt ID
P0DKC6
Species
Arabidopsis

Comments

Comment Type Description
Catalytic Activity An 11-beta-hydroxysteroid + NADP(+) = an 11- oxosteroid + NADPH. {ECO:0000269|PubMed:17074428}.
Developmental Stage Firstly detected during early seed maturation, at 9 days after anthesis (DAA), peaking at 18 DAA, before falling sharply during late maturation. {ECO:0000269|PubMed:19542545}.
Disruption Phenotype Semidwarf phenotype with reduced sensitivity to brassinosteroids (BRs) and enhanced sensitivity to abscisic acid (ABA) during germination. {ECO:0000269|PubMed:17616511}.
Function Catalyzes 11-beta, 17-beta-hydroxysteroid and reduces 17-beta-ketosteroids. Involved in regulating plant growth and development, probably promoting or mediating brassinosteroid effects. Plays a role during seed maturation. {ECO:0000269|PubMed:17074428, ECO:0000269|PubMed:17616511, ECO:0000269|PubMed:19542545}.
Induction By brassinosteroids (BRs). Up-regulated by LEC2. {ECO:0000269|PubMed:17616511, ECO:0000269|PubMed:19542545}.
Similarity Belongs to the short-chain dehydrogenases/reductases (SDR) family. {ECO:0000305}.
Subcellular Location Lipid droplet. Membrane; Single-pass type II membrane protein.
Tissue Specificity Expressed in the above-ground part of seedlings, especially in the vascular tissues. Also detected in the buds and silique pedicels. Highly induced in oil-accumulating tissues of maturing seeds. {ECO:0000269|PubMed:17616511, ECO:0000269|PubMed:19542545}.

Identical and Related Proteins

Unique RefSeq proteins for LMP009639 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
22327700 RefSeq NP_680418 349 hydroxysteroid dehydrogenase 1

Identical Sequences to LMP009639 proteins

Reference Database Accession Length Protein Name
GI:22327700 DBBJ BAD95411.1 349 11-beta-hydroxysteroid dehydrogenase-like [Arabidopsis thaliana]
GI:22327700 GenBank AGO81599.1 349 Sequence 6 from patent US 8399735
GI:22327700 gnl TAIR 349 hydroxysteroid dehydrogenase 1 [Arabidopsis thaliana]
GI:22327700 gnl TAIR 349 hydroxysteroid dehydrogenase 1 [Arabidopsis thaliana]
GI:22327700 SwissProt P0DKC6.1 349 RecName: Full=11-beta-hydroxysteroid dehydrogenase 1B; AltName: Full=17-beta-hydroxysteroid dehydrogenase 1B; AltName: Full=Hydroxysteroid dehydrogenase 1; Short=AtHSD1 [Arabidopsis thaliana]
GI:22327700 SwissProt P0DKC5.1 349 RecName: Full=11-beta-hydroxysteroid dehydrogenase 1A; AltName: Full=17-beta-hydroxysteroid dehydrogenase 1A; AltName: Full=Hydroxysteroid dehydrogenase 1; Short=AtHSD1 [Arabidopsis thaliana]

Related Sequences to LMP009639 proteins

Reference Database Accession Length Protein Name
GI:22327700 GenBank EFH42078.1 349 short-chain dehydrogenase/reductase family protein [Arabidopsis lyrata subsp. lyrata]
GI:22327700 GenBank EOA14998.1 349 hypothetical protein CARUB_v10028347mg [Capsella rubella]
GI:22327700 RefSeq XP_002865819.1 349 short-chain dehydrogenase/reductase family protein [Arabidopsis lyrata subsp. lyrata]
GI:22327700 RefSeq XP_006282100.1 349 hypothetical protein CARUB_v10028347mg [Capsella rubella]
GI:22327700 RefSeq XP_010442253.1 350 PREDICTED: 11-beta-hydroxysteroid dehydrogenase 1B-like [Camelina sativa]
GI:22327700 RefSeq XP_010442549.1 350 PREDICTED: 11-beta-hydroxysteroid dehydrogenase 1B [Camelina sativa]