Gene/Proteome Database (LMPD)

LMPD ID
LMP009693
Gene ID
817205
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
3-ketoacyl-CoA synthase 11
Gene Symbol
KCS11
Synonyms
3-ketoacyl-CoA synthase 11; F18A8.1; F18A8_1; KCS11
Alternate Names
3-ketoacyl-CoA synthase 11
Chromosome
2
EC Number
2.3.1.119
Summary
Encodes KCS11, a member of the 3-ketoacyl-CoA synthase family involved in the biosynthesis of VLCFA (very long chain fatty acids).
Orthologs
View orthologs and multiple alignments for KCS11

Proteins

3-ketoacyl-CoA synthase 11
Refseq ID NP_180232
Protein GI 15225767
UniProt ID O48780
mRNA ID NM_128221
Length 509
RefSeq Status REVIEWED
MDVEQKKPLIESSDRNLPDFKKSVKLKYVKLGYHYLITHGMYLFLSPLVLVIAAQISTFSVTDLRSLWEHLQYNLISVVVCSMLLVFLMTIYFMTRPRPVYLVNFSCFKPDESRKCTKKIFMDRSKLTGSFTEENLEFQRKILQRSGLGESTYLPEAVLNVPPNPCMKEARKEAETVMFGAIDELLAKTNVNPKDIGILIVNCSLFNPTPSLSAMVVNHYKLRGNILSYNLGGMGCSAGLISIDLAKHLLHSIPNTYAMVISMENITLNWYFGNDRSKLVSNCLFRMGGAAILLSNKRWDRRRSKYELVDTVRTHKGADDKCFGCITQEEDSASKIGVTLSKELMAVAGDALKTNITTLGPLVLPTSEQLLFFATLVGRKLFKMKIKPYIPDFKLAFEHFCIHAGGRAVLDELEKNLKLTEWHMEPSRMTLYRFGNTSSSSLWYELAYSEAKGRIKKGDRIWQIAFGSGFKCNSSVWRAVRSVNPKKEKNPWMDEIHEFPVEVPKVSTI

Gene Information

Entrez Gene ID
817205
Gene Name
3-ketoacyl-CoA synthase 11
Gene Symbol
KCS11
Species
Arabidopsis thaliana

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0033807 IEA:UniProtKB-EC F icosanoyl-CoA synthase activity
GO:0006633 IEA:UniProtKB-UniPathway P fatty acid biosynthetic process
GO:0009409 IEP:TAIR P response to cold
GO:0009416 IEP:TAIR P response to light stimulus

KEGG Pathway Links

KEGG Pathway ID Description
ath01110 Biosynthesis of secondary metabolites
ath_M00415 Fatty acid biosynthesis, elongation, endoplasmic reticulum
ath00062 Fatty acid elongation

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY-6803 phosphatidylcholine acyl editing

Domain Information

InterPro Annotations

Accession Description
IPR013747 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C-terminal
IPR013601 FAE1/Type III polyketide synthase-like protein
IPR016039 Thiolase-like
IPR016038 Thiolase-like, subgroup
IPR012392 Very-long-chain 3-ketoacyl-CoA synthase

UniProt Annotations

Entry Information

Gene Name
3-ketoacyl-CoA synthase 11
Protein Entry
KCS11_ARATH
UniProt ID
O48780
Species
Arabidopsis

Comments

Comment Type Description
Catalytic Activity A very-long-chain acyl-CoA + malonyl-CoA = CoA + a very-long-chain 3-oxoacyl-CoA + CO(2).
Catalytic Activity Stearoyl-CoA + malonyl-CoA + 2 NAD(P)H = icosanoyl-CoA + CO(2) + CoA + 2 NAD(P)(+) + H(2)O.
Function Active on both saturated and mono-unsaturated acyl chains C16 to C20. {ECO:0000269|PubMed:16765910}.
Induction Repressed by herbicides such as flufenacet and benfuresate. {ECO:0000269|PubMed:12916765}.
Pathway Lipid metabolism; fatty acid biosynthesis.
Similarity Belongs to the chalcone/stilbene synthases family. {ECO:0000305}.
Similarity Contains 1 FAE (fatty acid elongase) domain. {ECO:0000305}.
Subcellular Location Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Tissue Specificity Only expressed in guard cells.

Identical and Related Proteins

Unique RefSeq proteins for LMP009693 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
15225767 RefSeq NP_180232 509 3-ketoacyl-CoA synthase 11

Identical Sequences to LMP009693 proteins

Reference Database Accession Length Protein Name
GI:15225767 EMBL CAW71180.1 509 unnamed protein product [Arabidopsis thaliana]
GI:15225767 EMBL CBC11422.1 509 unnamed protein product [Arabidopsis thaliana]
GI:15225767 EMBL CBC60866.1 509 unnamed protein product [Arabidopsis thaliana]
GI:15225767 GenBank ACW92890.1 509 Sequence 11552 from patent US 7569389
GI:15225767 GenBank ACW93328.1 509 Sequence 12145 from patent US 7569389
GI:15225767 GenBank AEC07869.1 509 3-ketoacyl-CoA synthase 11 [Arabidopsis thaliana]

Related Sequences to LMP009693 proteins

Reference Database Accession Length Protein Name
GI:15225767 GenBank EFH55253.1 509 hypothetical protein ARALYDRAFT_901443 [Arabidopsis lyrata subsp. lyrata]
GI:15225767 GenBank EOA26425.1 509 hypothetical protein CARUB_v10024547mg [Capsella rubella]
GI:15225767 RefSeq XP_002878994.1 509 hypothetical protein ARALYDRAFT_901443 [Arabidopsis lyrata subsp. lyrata]
GI:15225767 RefSeq XP_006293527.1 509 hypothetical protein CARUB_v10024547mg [Capsella rubella]
GI:15225767 RefSeq XP_010417808.1 509 PREDICTED: 3-ketoacyl-CoA synthase 11 [Camelina sativa]
GI:15225767 RefSeq XP_010473049.1 509 PREDICTED: 3-ketoacyl-CoA synthase 11-like isoform X2 [Camelina sativa]