Gene/Proteome Database (LMPD)

LMPD ID
LMP009694
Gene ID
817412
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
3-ketoacyl-CoA synthase 12
Gene Symbol
KCS12
Synonyms
3-ketoacyl-CoA synthase 12; KCS12; T8O18.8; T8O18_8
Alternate Names
3-ketoacyl-CoA synthase 12
Chromosome
2
EC Number
2.3.1.199
Summary
Encodes KCS12, a member of the 3-ketoacyl-CoA synthase family involved in the biosynthesis of VLCFA (very long chain fatty acids).
Orthologs
View orthologs and multiple alignments for KCS12

Proteins

3-ketoacyl-CoA synthase 12
Refseq ID NP_180431
Protein GI 15226916
UniProt ID Q9SIB2
mRNA ID NM_128424
Length 476
RefSeq Status REVIEWED
MDLLFLFFSLLLSYLFFKIWKLIDSKQDKDCYILDYQCHKPTDDRMVSTQFSGEIIYRNQNLGLTEYKFLLKAIVSSGIGEQTYAPRLVFEGREERPSLQDGISEMEEFYVDSIGKLLERNQISPKDIDILVVNVSMLSSTPSLASRIINHYKMRDDVKVFNLTGMGCSASLISVDIVKNIFKSYANKLALVATSESLSPNWYSGNNRSMILANCLFRSGGCAILLTNKRSLRKKAMFKLKCMVRTHHGAREESYNCCIQAEDEQGRVGFYLGKNLPKAATRAFVENLKVITPKILPVTELIRFMLKLLIKKIKIRQNPSKGSTNLPPGTPLKAGINFKTGIEHFCIHTGGKAVIDGIGHSLDLNEYDIEPARMTLHRFGNTSASSLWYVLAYMEAKKRLKRGDRVFMISFGAGFKCNSCVWEVVRDLTGGESKGNVWNHCIDDYPPKSILNPYLEKFGWIQDEDPDTFKVPDAFM

Gene Information

Entrez Gene ID
817412
Gene Name
3-ketoacyl-CoA synthase 12
Gene Symbol
KCS12
Species
Arabidopsis thaliana

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IDA:TAIR C endoplasmic reticulum
GO:0016020 IEA:InterPro C membrane
GO:0016747 IEA:InterPro F transferase activity, transferring acyl groups other than amino-acyl groups
GO:0006633 IEA:UniProtKB-UniPathway P fatty acid biosynthetic process

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY-5080 very long chain fatty acid biosynthesis I

Domain Information

InterPro Annotations

Accession Description
IPR013747 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C-terminal
IPR013601 FAE1/Type III polyketide synthase-like protein
IPR016039 Thiolase-like
IPR016038 Thiolase-like, subgroup
IPR012392 Very-long-chain 3-ketoacyl-CoA synthase

UniProt Annotations

Entry Information

Gene Name
3-ketoacyl-CoA synthase 12
Protein Entry
KCS12_ARATH
UniProt ID
Q9SIB2
Species
Arabidopsis

Comments

Comment Type Description
Catalytic Activity A very-long-chain acyl-CoA + malonyl-CoA = CoA + a very-long-chain 3-oxoacyl-CoA + CO(2).
Induction Repressed by herbicides such as flufenacet and benfuresate. {ECO:0000269|PubMed:12916765}.
Pathway Lipid metabolism; fatty acid biosynthesis.
Similarity Belongs to the chalcone/stilbene synthases family. {ECO:0000305}.
Similarity Contains 1 FAE (fatty acid elongase) domain. {ECO:0000305}.

Identical and Related Proteins

Unique RefSeq proteins for LMP009694 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
15226916 RefSeq NP_180431 476 3-ketoacyl-CoA synthase 12

Identical Sequences to LMP009694 proteins

Reference Database Accession Length Protein Name
GI:15226916 GenBank AAL07019.1 476 putative fatty acid elongase [Arabidopsis thaliana]
GI:15226916 GenBank AAM14134.1 476 putative fatty acid elongase [Arabidopsis thaliana]
GI:15226916 GenBank AEC08152.1 476 3-ketoacyl-CoA synthase 12 [Arabidopsis thaliana]
GI:15226916 GenBank AGD03267.1 476 Sequence 723 from patent US 8343764
GI:15226916 gnl TIGR 476 putative fatty acid elongase [Arabidopsis thaliana]
GI:15226916 SwissProt Q9SIB2.1 476 RecName: Full=3-ketoacyl-CoA synthase 12; Short=KCS-12; AltName: Full=Very long-chain fatty acid condensing enzyme 12; Short=VLCFA condensing enzyme 12; Flags: Precursor [Arabidopsis thaliana]

Related Sequences to LMP009694 proteins

Reference Database Accession Length Protein Name
GI:15226916 GenBank AAM61290.1 476 putative fatty acid elongase [Arabidopsis thaliana]
GI:15226916 GenBank AGD17931.1 476 Sequence 15387 from patent US 8343764
GI:15226916 GenBank EOA27024.1 476 hypothetical protein CARUB_v10023121mg [Capsella rubella]
GI:15226916 GenBank ESQ51349.1 478 hypothetical protein EUTSA_v10016592mg [Eutrema salsugineum]
GI:15226916 RefSeq XP_006294126.1 476 hypothetical protein CARUB_v10023121mg [Capsella rubella]
GI:15226916 RefSeq XP_010510599.1 476 PREDICTED: 3-ketoacyl-CoA synthase 12 [Camelina sativa]