Gene/Proteome Database (LMPD)

LMPD ID
LMP009695
Gene ID
819284
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
3-ketoacyl-CoA synthase 13
Gene Symbol
KCS13
Synonyms
3-ketoacyl-CoA synthase 13; HIC; HIGH CARBON DIOXIDE; KCS13; T3A4.10
Alternate Names
3-ketoacyl-CoA synthase 13
Chromosome
2
EC Number
2.3.1.199
Summary
Encodes KCS13, a member of the 3-ketoacyl-CoA synthase family involved in the biosynthesis of VLCFA (very long chain fatty acids).
Orthologs
View orthologs and multiple alignments for KCS13

Proteins

3-ketoacyl-CoA synthase 13
Refseq ID NP_182195
Protein GI 15226428
UniProt ID Q9ZUZ0
mRNA ID NM_130237
Length 466
RefSeq Status REVIEWED
MFIAMADFKILLLILILISLFELDLLHFHHDFFSPFPVKIGLLLISIFFYAYSTTRSKPVYLVDFSCHQPTDSCKISSETFFNMAKGAQLYTDETIQFMTRILNRSGLGDDTYSPRCMLTSPPTPSMYEARHESELVIFGALNSLFKKTGIEPREVGIFIVNCSLFNPNPSLSSMIVNRYKLKTDVKTYNLSGMGCSAGAISVDLATNLLKANPNTYAVIVSTENMTLSMYRGNDRSMLVPNCLFRVGGAAVMLSNRSQDRVRSKYELTHIVRTHKGSSDKHYTCAEQKEDSKGIVGVALSKELTVVAGDSLKTNLTALGPLVLPLSEKLRFILFLVKSKLFRLKVSPYVPDFKLCFKHFCIHAGGRALLDAVEKGLGLSEFDLEPSRMTLHRFGNTSSSSLWYELAYVEAKCRVKRGDRVWQLAFGSGFKCNSIVWRALRTIPANESLVGNPWGDSVHKYPVHVT

Gene Information

Entrez Gene ID
819284
Gene Name
3-ketoacyl-CoA synthase 13
Gene Symbol
KCS13
Species
Arabidopsis thaliana

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0016747 IEA:InterPro F transferase activity, transferring acyl groups other than amino-acyl groups
GO:0006633 IEA:UniProtKB-UniPathway P fatty acid biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
ath01110 Biosynthesis of secondary metabolites
ath_M00415 Fatty acid biosynthesis, elongation, endoplasmic reticulum
ath00062 Fatty acid elongation

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY-5080 very long chain fatty acid biosynthesis I

Domain Information

InterPro Annotations

Accession Description
IPR013747 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C-terminal
IPR013601 FAE1/Type III polyketide synthase-like protein
IPR016039 Thiolase-like
IPR016038 Thiolase-like, subgroup
IPR012392 Very-long-chain 3-ketoacyl-CoA synthase

UniProt Annotations

Entry Information

Gene Name
3-ketoacyl-CoA synthase 13
Protein Entry
KCS13_ARATH
UniProt ID
Q9ZUZ0
Species
Arabidopsis

Comments

Comment Type Description
Catalytic Activity A very-long-chain acyl-CoA + malonyl-CoA = CoA + a very-long-chain 3-oxoacyl-CoA + CO(2).
Function Contributes to cuticular wax and suberin biosynthesis (By similarity). Regulates negatively the stomatal development in elevated CO(2) conditions. {ECO:0000250, ECO:0000269|PubMed:11130071}.
Induction Repressed by herbicides such as flufenacet and benfuresate. {ECO:0000269|PubMed:12916765}.
Pathway Lipid metabolism; fatty acid biosynthesis.
Similarity Belongs to the chalcone/stilbene synthases family. {ECO:0000305}.
Similarity Contains 1 FAE (fatty acid elongase) domain. {ECO:0000305}.
Subcellular Location Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.

Identical and Related Proteins

Unique RefSeq proteins for LMP009695 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
15226428 RefSeq NP_182195 466 3-ketoacyl-CoA synthase 13

Identical Sequences to LMP009695 proteins

Reference Database Accession Length Protein Name
GI:15226428 EMBL CAW45921.1 466 unnamed protein product [Arabidopsis thaliana]
GI:15226428 EMBL CAW71181.1 466 unnamed protein product [Arabidopsis thaliana]
GI:15226428 EMBL CBC11423.1 466 unnamed protein product [Arabidopsis thaliana]
GI:15226428 EMBL CBC60868.1 466 unnamed protein product [Arabidopsis thaliana]
GI:15226428 GenBank AEC10745.1 466 3-ketoacyl-CoA synthase 13 [Arabidopsis thaliana]
GI:15226428 SwissProt Q9ZUZ0.1 466 RecName: Full=3-ketoacyl-CoA synthase 13; Short=KCS-13; AltName: Full=Protein HIGH CARBON DIOXIDE; AltName: Full=Very long-chain fatty acid condensing enzyme 13; Short=VLCFA condensing enzyme 13; Flags: Precursor [Arabidopsis thaliana]

Related Sequences to LMP009695 proteins

Reference Database Accession Length Protein Name
GI:15226428 EMBL CAW45922.1 459 unnamed protein product [Arabidopsis thaliana]
GI:15226428 EMBL CAW71182.1 459 unnamed protein product [Arabidopsis thaliana]
GI:15226428 EMBL CBC11424.1 459 unnamed protein product [Arabidopsis thaliana]
GI:15226428 EMBL CBC60870.1 459 unnamed protein product [Arabidopsis thaliana]
GI:15226428 GenBank ACX06982.1 459 Sequence 30721 from patent US 7569389
GI:15226428 SwissProt Q9SS39.1 459 RecName: Full=Probable 3-ketoacyl-CoA synthase 14; Short=KCS-14; AltName: Full=Very long-chain fatty acid condensing enzyme 14; Short=VLCFA condensing enzyme 14; Flags: Precursor [Arabidopsis thaliana]