Gene/Proteome Database (LMPD)

LMPD ID
LMP009698
Gene ID
839578
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
3-ketoacyl-CoA synthase 2
Gene Symbol
KCS2
Synonyms
3-ketoacyl-CoA synthase 2; F20D22.1; F20D22_1; KCS2
Alternate Names
3-ketoacyl-CoA synthase 2
Chromosome
1
EC Number
2.3.1.199
Summary
Encodes KCS2, a member of the 3-ketoacyl-CoA synthase family involved in the biosynthesis of VLCFA (very long chain fatty acids).
Orthologs
View orthologs and multiple alignments for KCS2

Proteins

3-ketoacyl-CoA synthase 2
Refseq ID NP_171918
Protein GI 15219676
UniProt ID Q5XEP9
mRNA ID NM_100303
Length 528
RefSeq Status REVIEWED
MNENHIQSDHMNNTIHVTNKKLPNFLLSVRLKYVKLGYHYLISNAVYILILPVGLLAATSSSFSLTDLTLLYNHLLKFHFLSSTLFAALLIFLTTLYFTTRPRRIFLLDFACYKPDSSLICTRETFMDRSQRVGIFTEDNLAFQQKILERSGLGQKTYFPEALLRVPPNPCMSEARKEAETVMFGAIDAVLEKTGVNPKDIGILVVNCSLFNPTPSLSAMIVNKYKLRGNVLSYNLGGMGCSAGLISIDLAKQLLQVQPNSYALVVSTENITLNWYLGNDRSMLLSNCIFRMGGAAVLLSNRSSDRCRSKYQLIHTVRTHKGSDDNAFNCVYQREDNDDNKQIGVSLSKNLMAIAGEALKTNITTLGPLVLPMSEQLLFFATLVARKVFNVKKIKPYIPDFKLAFEHFCIHAGGRAVLDEIEKNLDLSEWHMEPSRMTLNRFGNTSSSSLWYELAYSEAKGRIKRGDRTWQIAFGSGFKCNSAVWRALRTIDPSKEKKKKTNPWIDEIHEFPVPVPRTSPVTSSSESR

Gene Information

Entrez Gene ID
839578
Gene Name
3-ketoacyl-CoA synthase 2
Gene Symbol
KCS2
Species
Arabidopsis thaliana

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0009922 IDA:TAIR F fatty acid elongase activity
GO:0006633 IEA:UniProtKB-UniPathway P fatty acid biosynthetic process
GO:0006970 IEP:TAIR P response to osmotic stress
GO:0009611 IEP:TAIR P response to wounding
GO:0010345 IMP:TAIR P suberin biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
ath01110 Biosynthesis of secondary metabolites
ath_M00415 Fatty acid biosynthesis, elongation, endoplasmic reticulum
ath00062 Fatty acid elongation

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY-6803 phosphatidylcholine acyl editing

Domain Information

InterPro Annotations

Accession Description
IPR013747 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C-terminal
IPR013601 FAE1/Type III polyketide synthase-like protein
IPR016039 Thiolase-like
IPR016038 Thiolase-like, subgroup
IPR012392 Very-long-chain 3-ketoacyl-CoA synthase

UniProt Annotations

Entry Information

Gene Name
3-ketoacyl-CoA synthase 2
Protein Entry
KCS17_ARATH
UniProt ID
Q5XEP9
Species
Arabidopsis

Comments

Comment Type Description
Catalytic Activity A very-long-chain acyl-CoA + malonyl-CoA = CoA + a very-long-chain 3-oxoacyl-CoA + CO(2).
Caution It is uncertain whether Met-1 or Met-11 is the initiator. {ECO:0000305}.
Enzyme Regulation Inhibited by K3 herbicides such as allidochlor, anilofos, cafenstrole and flufenacet. {ECO:0000269|PubMed:15277688}.
Function Mediates the synthesis of VLCFAs from 22 to 26 carbons in length (e.g. C22, C24, C26). {ECO:0000269|PubMed:15277688}.
Induction Repressed by herbicides such as flufenacet and benfuresate. {ECO:0000269|PubMed:12916765}.
Pathway Lipid metabolism; fatty acid biosynthesis.
Sequence Caution Sequence=BAD95022.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Similarity Belongs to the chalcone/stilbene synthases family. {ECO:0000305}.
Similarity Contains 1 FAE (fatty acid elongase) domain. {ECO:0000305}.
Subcellular Location Membrane {ECO:0000269|PubMed:15277688}; Multi-pass membrane protein {ECO:0000269|PubMed:15277688}.

Identical and Related Proteins

Unique RefSeq proteins for LMP009698 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
15219676 RefSeq NP_171918 528 3-ketoacyl-CoA synthase 2

Identical Sequences to LMP009698 proteins

Reference Database Accession Length Protein Name
GI:15219676 EMBL CAW45915.1 528 unnamed protein product [Arabidopsis thaliana]
GI:15219676 EMBL CAW71175.1 528 unnamed protein product [Arabidopsis thaliana]
GI:15219676 EMBL CBC11417.1 528 unnamed protein product [Arabidopsis thaliana]
GI:15219676 EMBL CBC60856.1 528 unnamed protein product [Arabidopsis thaliana]
GI:15219676 GenBank AEE27671.1 528 3-ketoacyl-CoA synthase 2 [Arabidopsis thaliana]
GI:15219676 SwissProt Q5XEP9.2 528 RecName: Full=3-ketoacyl-CoA synthase 17; Short=KCS-17; AltName: Full=Very long-chain fatty acid condensing enzyme 17; Short=VLCFA condensing enzyme 17 [Arabidopsis thaliana]

Related Sequences to LMP009698 proteins

Reference Database Accession Length Protein Name
GI:15219676 GenBank AAL67132.1 523 putative beta-ketoacyl-CoA synthase, partial [Arabidopsis thaliana]
GI:15219676 GenBank AAU95453.1 518 At1g04220 [Arabidopsis thaliana]
GI:15219676 GenBank EFH68460.1 524 hypothetical protein ARALYDRAFT_470398 [Arabidopsis lyrata subsp. lyrata]
GI:15219676 GenBank EOA40149.1 518 hypothetical protein CARUB_v10008867mg [Capsella rubella]
GI:15219676 RefSeq XP_002892201.1 524 hypothetical protein ARALYDRAFT_470398 [Arabidopsis lyrata subsp. lyrata]
GI:15219676 RefSeq XP_006307251.1 518 hypothetical protein CARUB_v10008867mg [Capsella rubella]