Gene/Proteome Database (LMPD)

LMPD ID
LMP009699
Gene ID
829603
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
3-ketoacyl-CoA synthase 18
Gene Symbol
KCS18
Synonyms
3-ketoacyl-CoA synthase 18; FAE1; FATTY ACID ELONGATION1; KCS18; T4L20.100; T4L20_100
Alternate Names
3-ketoacyl-CoA synthase 18
Chromosome
4
EC Number
2.3.1.119
Summary
Encodes KCS18, a member of the 3-ketoacyl-CoA synthase family involved in the biosynthesis of VLCFA (very long chain fatty acids).
Orthologs
View orthologs and multiple alignments for KCS18

Proteins

3-ketoacyl-CoA synthase 18
Refseq ID NP_195178
Protein GI 15236144
UniProt ID Q38860
mRNA ID NM_119617
Length 506
RefSeq Status REVIEWED
MTSVNVKLLYRYVLTNFFNLCLFPLTAFLAGKASRLTINDLHNFLSYLQHNLITVTLLFAFTVFGLVLYIVTRPNPVYLVDYSCYLPPPHLKVSVSKVMDIFYQIRKADTSSRNVACDDPSSLDFLRKIQERSGLGDETYSPEGLIHVPPRKTFAASREETEKVIIGALENLFENTKVNPREIGILVVNSSMFNPTPSLSAMVVNTFKLRSNIKSFNLGGMGCSAGVIAIDLAKDLLHVHKNTYALVVSTENITQGIYAGENRSMMVSNCLFRVGGAAILLSNKSGDRRRSKYKLVHTVRTHTGADDKSFRCVQQEDDESGKIGVCLSKDITNVAGTTLTKNIATLGPLILPLSEKFLFFATFVAKKLLKDKIKHYYVPDFKLAVDHFCIHAGGRAVIDELEKNLGLSPIDVEASRSTLHRFGNTSSSSIWYELAYIEAKGRMKKGNKAWQIALGSGFKCNSAVWVALRNVKASANSPWQHCIDRYPVKIDSDLSKSKTHVQNGRS

Gene Information

Entrez Gene ID
829603
Gene Name
3-ketoacyl-CoA synthase 18
Gene Symbol
KCS18
Species
Arabidopsis thaliana

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0009922 IDA:TAIR F fatty acid elongase activity
GO:0033807 IEA:UniProtKB-EC F icosanoyl-CoA synthase activity
GO:0006633 IEA:UniProtKB-UniPathway P fatty acid biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
ath01110 Biosynthesis of secondary metabolites
ath_M00415 Fatty acid biosynthesis, elongation, endoplasmic reticulum
ath00062 Fatty acid elongation

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY-7036 very long chain fatty acid biosynthesis II

Domain Information

InterPro Annotations

Accession Description
IPR013747 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C-terminal
IPR013601 FAE1/Type III polyketide synthase-like protein
IPR016039 Thiolase-like
IPR016038 Thiolase-like, subgroup
IPR012392 Very-long-chain 3-ketoacyl-CoA synthase

UniProt Annotations

Entry Information

Gene Name
3-ketoacyl-CoA synthase 18
Protein Entry
KCS18_ARATH
UniProt ID
Q38860
Species
Arabidopsis

Comments

Comment Type Description
Catalytic Activity A very-long-chain acyl-CoA + malonyl-CoA = CoA + a very-long-chain 3-oxoacyl-CoA + CO(2).
Catalytic Activity Stearoyl-CoA + malonyl-CoA + 2 NAD(P)H = icosanoyl-CoA + CO(2) + CoA + 2 NAD(P)(+) + H(2)O.
Developmental Stage Accumulates in upper part of roots, hypocotyls and cotyledons of developing embryo. Levels increase in early stages (torpedo, 4 days after flowering) and decrease during late stages of embryo development. {ECO:0000269|PubMed:11575726}.
Enzyme Regulation Inhibited by K3 herbicides such as allidochlor, cafenstrole and flufenacet. {ECO:0000269|PubMed:15277688}.
Function Contributes to fatty acids elongation and stockage in developing seeds. Active on both saturated and mono-unsaturated acyl-CoAs of 16 and 18 carbons. Required for the elongation of C18 to C20 and of C20 to C22 fatty acids. Mediates also the synthesis of VLCFAs from 20 to 26 carbons in length (e.g. C20:1, C20, C22:1, C22, C24:1, C24, C26). {ECO:0000269|PubMed:15277688, ECO:0000269|PubMed:16765910, ECO:0000269|PubMed:7734965, ECO:0000269|PubMed:9263455, ECO:0000269|Ref.4, ECO:0000269|Ref.5}.
Induction Repressed by herbicides such as flufenacet and benfuresate. {ECO:0000269|PubMed:12916765}.
Pathway Lipid metabolism; fatty acid biosynthesis.
Similarity Belongs to the chalcone/stilbene synthases family. {ECO:0000305}.
Similarity Contains 1 FAE (fatty acid elongase) domain. {ECO:0000305}.
Subcellular Location Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Tissue Specificity Expressed specifically in seeds, especially in embryos. {ECO:0000269|PubMed:11575726, ECO:0000269|PubMed:7734965}.

Identical and Related Proteins

Unique RefSeq proteins for LMP009699 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
15236144 RefSeq NP_195178 506 3-ketoacyl-CoA synthase 18

Identical Sequences to LMP009699 proteins

Reference Database Accession Length Protein Name
GI:15236144 EMBL CAW45923.1 506 unnamed protein product [Arabidopsis thaliana]
GI:15236144 EMBL CAW71183.1 506 unnamed protein product [Arabidopsis thaliana]
GI:15236144 EMBL CBC11425.1 506 unnamed protein product [Arabidopsis thaliana]
GI:15236144 EMBL CBC60872.1 506 unnamed protein product [Arabidopsis thaliana]
GI:15236144 GenBank ACH17554.1 506 Sequence 151 from patent US 7402667
GI:15236144 GenBank AEE86388.1 506 3-ketoacyl-CoA synthase 18 [Arabidopsis thaliana]

Related Sequences to LMP009699 proteins

Reference Database Accession Length Protein Name
GI:15236144 EMBL CAD23313.1 506 unnamed protein product [synthetic construct]
GI:15236144 EMBL CAD23316.1 506 unnamed protein product [synthetic construct]
GI:15236144 GenBank AAT24354.1 506 Sequence 30 from patent US 6713664
GI:15236144 GenBank AAT24357.1 506 Sequence 36 from patent US 6713664
GI:15236144 GenBank EFH45401.1 505 hypothetical protein ARALYDRAFT_912937 [Arabidopsis lyrata subsp. lyrata]
GI:15236144 RefSeq XP_002869142.1 505 hypothetical protein ARALYDRAFT_912937 [Arabidopsis lyrata subsp. lyrata]