Gene/Proteome Database (LMPD)

LMPD ID
LMP009704
Gene ID
838528
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
3-ketoacyl-CoA synthase 4
Gene Symbol
KCS4
Synonyms
3-ketoacyl-CoA synthase 4; F18O14.21; F18O14_21; KCS4
Alternate Names
3-ketoacyl-CoA synthase 4
Chromosome
1
EC Number
2.3.1.199
Summary
Encodes KCS4, a member of the 3-ketoacyl-CoA synthase family involved in the biosynthesis of VLCFA (very long chain fatty acids).
Orthologs
View orthologs and multiple alignments for KCS4

Proteins

3-ketoacyl-CoA synthase 4
Refseq ID NP_173376
Protein GI 15223556
UniProt ID Q9LN49
mRNA ID NM_101800
Length 516
RefSeq Status REVIEWED
MDGAGESRLGGDGGGDGSVGVQIRQTRMLPDFLQSVNLKYVKLGYHYLISNLLTLCLFPLAVVISVEASQMNPDDLKQLWIHLQYNLVSIIICSAILVFGLTVYVMTRPRPVYLVDFSCYLPPDHLKAPYARFMEHSRLTGDFDDSALEFQRKILERSGLGEDTYVPEAMHYVPPRISMAAAREEAEQVMFGALDNLFANTNVKPKDIGILVVNCSLFNPTPSLSAMIVNKYKLRGNIRSYNLGGMGCSAGVIAVDLAKDMLLVHRNTYAVVVSTENITQNWYFGNKKSMLIPNCLFRVGGSAVLLSNKSRDKRRSKYRLVHVVRTHRGADDKAFRCVYQEQDDTGRTGVSLSKDLMAIAGETLKTNITTLGPLVLPISEQILFFMTLVVKKLFNGKVKPYIPDFKLAFEHFCIHAGGRAVIDELEKNLQLSPVHVEASRMTLHRFGNTSSSSIWYELAYIEAKGRMRRGNRVWQIAFGSGFKCNSAIWEALRHVKPSNNSPWEDCIDKYPVTLSY

Gene Information

Entrez Gene ID
838528
Gene Name
3-ketoacyl-CoA synthase 4
Gene Symbol
KCS4
Species
Arabidopsis thaliana

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0016747 IEA:InterPro F transferase activity, transferring acyl groups other than amino-acyl groups
GO:0006633 IEA:UniProtKB-UniPathway P fatty acid biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
ath01110 Biosynthesis of secondary metabolites
ath_M00415 Fatty acid biosynthesis, elongation, endoplasmic reticulum
ath00062 Fatty acid elongation

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY-6803 phosphatidylcholine acyl editing

Domain Information

InterPro Annotations

Accession Description
IPR013747 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C-terminal
IPR013601 FAE1/Type III polyketide synthase-like protein
IPR016039 Thiolase-like
IPR016038 Thiolase-like, subgroup
IPR012392 Very-long-chain 3-ketoacyl-CoA synthase

UniProt Annotations

Entry Information

Gene Name
3-ketoacyl-CoA synthase 4
Protein Entry
KCS4_ARATH
UniProt ID
Q9LN49
Species
Arabidopsis

Comments

Comment Type Description
Catalytic Activity A very-long-chain acyl-CoA + malonyl-CoA = CoA + a very-long-chain 3-oxoacyl-CoA + CO(2).
Induction Repressed by herbicides such as flufenacet and benfuresate. {ECO:0000269|PubMed:12916765}.
Pathway Lipid metabolism; fatty acid biosynthesis.
Similarity Belongs to the chalcone/stilbene synthases family. {ECO:0000305}.
Similarity Contains 1 FAE (fatty acid elongase) domain. {ECO:0000305}.
Subcellular Location Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.

Identical and Related Proteins

Unique RefSeq proteins for LMP009704 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
15223556 RefSeq NP_173376 516 3-ketoacyl-CoA synthase 4

Identical Sequences to LMP009704 proteins

Reference Database Accession Length Protein Name
GI:15223556 EMBL CBC11419.1 516 unnamed protein product [Arabidopsis thaliana]
GI:15223556 EMBL CBC60860.1 516 unnamed protein product [Arabidopsis thaliana]
GI:15223556 GenBank ACW92823.1 516 Sequence 11462 from patent US 7569389
GI:15223556 GenBank ACX18089.1 516 Sequence 45798 from patent US 7569389
GI:15223556 GenBank AEE29852.1 516 3-ketoacyl-CoA synthase 4 [Arabidopsis thaliana]
GI:15223556 GenBank AFL64796.1 516 Sequence 42 from patent US 8188339

Related Sequences to LMP009704 proteins

Reference Database Accession Length Protein Name
GI:15223556 EMBL CAM90926.1 516 unnamed protein product [unidentified]
GI:15223556 EMBL CAZ79152.1 516 unnamed protein product [Arabidopsis thaliana]
GI:15223556 EMBL CAZ79153.1 516 unnamed protein product [Arabidopsis thaliana]
GI:15223556 RefSeq XP_010498362.1 516 PREDICTED: 3-ketoacyl-CoA synthase 4 [Camelina sativa]
GI:15223556 RefSeq XP_010459615.1 518 PREDICTED: 3-ketoacyl-CoA synthase 4-like [Camelina sativa]
GI:15223556 RefSeq XP_010477163.1 517 PREDICTED: 3-ketoacyl-CoA synthase 4-like [Camelina sativa]