Gene/Proteome Database (LMPD)

LMPD ID
LMP009708
Gene ID
815998
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
3-ketoacyl-CoA synthase 8
Gene Symbol
KCS8
Synonyms
3-ketoacyl-CoA synthase 8; KCS8; T15J14.13; T15J14_13
Alternate Names
3-ketoacyl-CoA synthase 8
Chromosome
2
EC Number
2.3.1.199
Summary
Encodes KCS8, a member of the 3-ketoacyl-CoA synthase family involved in the biosynthesis of VLCFA (very long chain fatty acids).
Orthologs
View orthologs and multiple alignments for KCS8

Proteins

3-ketoacyl-CoA synthase 8
Refseq ID NP_179113
Protein GI 30679326
UniProt ID Q4V3C9
mRNA ID NM_127071
Length 481
RefSeq Status REVIEWED
MKNLKMVFFKILFISLMAGLAMKGSKINVEDLQKFSLHHTQNNLQTISLLLFLVVFVWILYMLTRPKPVYLVDFSCYLPPSHLKVSIQTLMGHARRAREAGMCWKNKESDHLVDFQEKILERSGLGQETYIPEGLQCFPLQQGMGASRKETEEVIFGALDNLFRNTGVKPDDIGILVVNSSTFNPTPSLASMIVNKYKLRDNIKSLNLGGMGCSAGVIAVDVAKGLLQVHRNTYAIVVSTENITQNLYLGKNKSMLVTNCLFRVGGAAVLLSNRSRDRNRAKYELVHTVRIHTGSDDRSFECATQEEDEDGIIGVTLTKNLPMVAARTLKINIATLGPLVLPLKEKLAFFITFVKKKYFKPELRNYTPDFKLAFEHFCIHAGGRALIDELEKNLKLSPLHVEASRMTLHRFGNTSSSSIWYELAYTEAKGRMKEGDRIWQIALGSGFKCNSSVWVALRDVKPSANSPWEDCMDRYPVEIDI

Gene Information

Entrez Gene ID
815998
Gene Name
3-ketoacyl-CoA synthase 8
Gene Symbol
KCS8
Species
Arabidopsis thaliana

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IDA:TAIR C endoplasmic reticulum
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0016747 IEA:InterPro F transferase activity, transferring acyl groups other than amino-acyl groups
GO:0006633 IEA:UniProtKB-UniPathway P fatty acid biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
ath01110 Biosynthesis of secondary metabolites
ath_M00415 Fatty acid biosynthesis, elongation, endoplasmic reticulum
ath00062 Fatty acid elongation

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY-5080 very long chain fatty acid biosynthesis I

Domain Information

InterPro Annotations

Accession Description
IPR013747 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C-terminal
IPR013601 FAE1/Type III polyketide synthase-like protein
IPR016039 Thiolase-like
IPR016038 Thiolase-like, subgroup
IPR012392 Very-long-chain 3-ketoacyl-CoA synthase

UniProt Annotations

Entry Information

Gene Name
3-ketoacyl-CoA synthase 8
Protein Entry
KCS8_ARATH
UniProt ID
Q4V3C9
Species
Arabidopsis

Comments

Comment Type Description
Catalytic Activity A very-long-chain acyl-CoA + malonyl-CoA = CoA + a very-long-chain 3-oxoacyl-CoA + CO(2).
Induction Repressed by herbicides such as flufenacet and benfuresate. {ECO:0000269|PubMed:12916765}.
Pathway Lipid metabolism; fatty acid biosynthesis.
Sequence Caution Sequence=AAD03366.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Similarity Belongs to the chalcone/stilbene synthases family. {ECO:0000305}.
Similarity Contains 1 FAE (fatty acid elongase) domain. {ECO:0000305}.
Subcellular Location Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.

Identical and Related Proteins

Unique RefSeq proteins for LMP009708 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
30679326 RefSeq NP_179113 481 3-ketoacyl-CoA synthase 8

Identical Sequences to LMP009708 proteins

Reference Database Accession Length Protein Name
GI:30679326 EMBL CAW45919.1 481 unnamed protein product [Arabidopsis thaliana]
GI:30679326 EMBL CAW71179.1 481 unnamed protein product [Arabidopsis thaliana]
GI:30679326 EMBL CBC11421.1 481 unnamed protein product [Arabidopsis thaliana]
GI:30679326 EMBL CBC60864.1 481 unnamed protein product [Arabidopsis thaliana]
GI:30679326 GenBank ACX06079.1 481 Sequence 29496 from patent US 7569389
GI:30679326 GenBank AEC06369.1 481 3-ketoacyl-CoA synthase 8 [Arabidopsis thaliana]

Related Sequences to LMP009708 proteins

Reference Database Accession Length Protein Name
GI:30679326 EMBL CAW45975.1 476 unnamed protein product [Arabidopsis thaliana]
GI:30679326 EMBL CAW71235.1 476 unnamed protein product [Arabidopsis thaliana]
GI:30679326 EMBL CBC11477.1 476 unnamed protein product [Arabidopsis thaliana]
GI:30679326 EMBL CBC60973.1 476 unnamed protein product [Arabidopsis thaliana]
GI:30679326 GenBank AAE84923.1 504 Sequence 6 from patent US 6307128
GI:30679326 GenBank ACX06080.1 476 Sequence 29497 from patent US 7569389