Gene/Proteome Database (LMPD)

LMPD ID
LMP009710
Gene ID
839434
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
3-ketoacyl-CoA thiolase 1
Gene Symbol
PKT4
Synonyms
3-KETO-ACYL-COA THIOLASE 1; KAT1; peroxisomal 3-ketoacyl-CoA thiolase 4; PKT4; T1G11.4; T1G11_4
Alternate Names
3-ketoacyl-CoA thiolase 1
Chromosome
1
EC Number
2.3.1.16
Summary
EC2.3.1.16 thiolase.
Orthologs
View orthologs and multiple alignments for PKT4

Proteins

3-ketoacyl-CoA thiolase 1
Refseq ID NP_171965
Protein GI 15219797
UniProt ID Q8LF48
mRNA ID NM_100351
Length 443
RefSeq Status REVIEWED
MEKATERQRILLRHLQPSSSSDASLSASACLSKDSAAYQYGDDVVIVAAQRTALCKAKRGSFKDTFPDELLASVLRALIEKTNVNPSEVGDIVVGTVLGPGSQRASECRMAAFYAGFPETVPIRTVNRQCSSGLQAVADVAAAIKAGFYDIGIGAGLESMTTNPRGWKGSVNPNVKKFEQAHNCLLPMGITSENVAHRFNVSREEQDQAAVDSHRKAASATASGKFKDEITPVKTKIVDPKTGDEKPITVSVDDGIRPNTTLSGLAKLKPVFKEDGTTTAGNSSQLSDGAGAVLLMRRNVAMQKGLPILGVFRTFSAVGVDPAIMGVGPAVAIPAAVKAAGLELNDVDLFEINEAFASQFVYCRNKLGLDAEKINVNGGAIAIGHPLGATGARCVATLLHEMKRRGKDCRFGVVSMCIGSGMGAAAVFERGGGVDELCDVRKV

Gene Information

Entrez Gene ID
839434
Gene Name
3-ketoacyl-CoA thiolase 1
Gene Symbol
PKT4
Species
Arabidopsis thaliana

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005777 IDA:TAIR C peroxisome
GO:0005773 IDA:TAIR C vacuole
GO:0003988 IEA:UniProtKB-EC F acetyl-CoA C-acyltransferase activity
GO:0031408 IEA:UniProtKB-KW P oxylipin biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
ath_M00087 beta-Oxidation
ath01040 Biosynthesis of unsaturated fatty acids
ath_M00113 Jasmonic acid biosynthesis
ath04146 Peroxisome

Domain Information

InterPro Annotations

Accession Description
IPR002155 Thiolase
IPR020610 Thiolase, active site
IPR020615 Thiolase, acyl-enzyme intermediate active site
IPR020613 Thiolase, conserved site
IPR020617 Thiolase, C-terminal
IPR016039 Thiolase-like
IPR016038 Thiolase-like, subgroup
IPR020616 Thiolase, N-terminal

UniProt Annotations

Entry Information

Gene Name
3-ketoacyl-CoA thiolase 1
Protein Entry
THIK1_ARATH
UniProt ID
Q8LF48
Species
Arabidopsis

Comments

Comment Type Description
Catalytic Activity Acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA.
Function Involved in fatty-acid beta-oxidation prior to gluconeogenesis during germination and subsequent seedling growth. Implicated in jasmonic acid (JA) biosynthesis (By similarity). {ECO:0000250}.
Pathway Lipid metabolism; fatty acid metabolism.
Sequence Caution Sequence=AAB80634.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Similarity Belongs to the thiolase family. {ECO:0000305}.
Subcellular Location Peroxisome {ECO:0000250}.
Subunit Homodimer. {ECO:0000250}.
Tissue Specificity Low levels in seedlings and leaves. {ECO:0000269|PubMed:11696182, ECO:0000269|PubMed:15141068}.

Identical and Related Proteins

Unique RefSeq proteins for LMP009710 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
15219797 RefSeq NP_171965 443 3-ketoacyl-CoA thiolase 1

Identical Sequences to LMP009710 proteins

Reference Database Accession Length Protein Name
GI:15219797 GenBank AAO00648.1 443 Sequence 14 from patent US 6489461
GI:15219797 GenBank AAO30078.1 443 putative acetyl-CoA acyltransferase [Arabidopsis thaliana]
GI:15219797 GenBank ACW86547.1 443 Sequence 2916 from patent US 7569389
GI:15219797 GenBank ACW87193.1 443 Sequence 3794 from patent US 7569389
GI:15219797 GenBank AEE27736.1 443 3-ketoacyl-CoA thiolase 1 [Arabidopsis thaliana]
GI:15219797 SwissProt Q8LF48.2 443 RecName: Full=3-ketoacyl-CoA thiolase 1, peroxisomal; AltName: Full=Acetyl-CoA acyltransferase 1; AltName: Full=Beta-ketothiolase 1; AltName: Full=Peroxisomal 3-oxoacyl-CoA thiolase 1; Flags: Precursor [Arabidopsis thaliana]

Related Sequences to LMP009710 proteins

Reference Database Accession Length Protein Name
GI:15219797 GenBank AAB80634.1 460 Strong similarity to Cucumis acetyl-CoA acyltransferase (gb|D70895) [Arabidopsis thaliana]
GI:15219797 GenBank AAM61609.1 443 putative acetyl-CoA acyltransferase [Arabidopsis thaliana]
GI:15219797 GenBank ACW86546.1 453 Sequence 2915 from patent US 7569389
GI:15219797 GenBank ACW87192.1 453 Sequence 3793 from patent US 7569389
GI:15219797 GenBank EOA40415.1 444 hypothetical protein CARUB_v10009140mg [Capsella rubella]
GI:15219797 RefSeq XP_006307517.1 444 hypothetical protein CARUB_v10009140mg [Capsella rubella]