Gene/Proteome Database (LMPD)

LMPD ID
LMP009712
Gene ID
834946
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
3-keto-acyl-CoA thiolase 2
Gene Symbol
PKT2
Synonyms
3-KETO-ACYL-COA THIOLASE; 3-KETO-ACYL-COENZYME A THIOLASE 5; K24G6.22; K24G6_22; KAT5; peroxisomal 3-keto-acyl-CoA thiolase 2; PEROXISOMAL 3-KETO-ACYL-COA THIOLASE 2; PEROXISOMAL-3-KETO-ACYL-COA THIOLASE 1; PKT1; PKT2
Alternate Names
3-keto-acyl-CoA thiolase 2
Chromosome
5
EC Number
2.3.1.16

Proteins

3-keto-acyl-CoA thiolase 2
Refseq ID NP_851157
Protein GI 30695561
UniProt ID Q570C8
mRNA ID NM_180826
Length 414
RefSeq Status REVIEWED
MAAFGDDIVIVAAYRTAICKARRGGFKDTLPDDLLASVLKAVVERTSLDPSEVGDIVVGTVIAPGSQRAMECRVAAYFAGFPDSVPVRTVNRQCSSGLQAVADVAASIRAGYYDIGIGAGVESMSTDHIPGGGFHGSNPRAQDFPKARDCLLPMGITSENVAERFGVTREEQDMAAVESHKRAAAAIASGKLKDEIIPVATKIVDPETKAEKAIVVSVDDGVRPNSNMADLAKLKTVFKQNGSTTAGNASQISDGAGAVLLMKRSLAMKKGLPILGVFRSFAVTGVEPSVMGIGPAVAIPAATKLAGLNVSDIDLFEINEAFASQYVYSCKKLELDMEKVNVNGGAIAIGHPLGATGARCVATLLHEMKRRGKDCRFGVISMCIGTGMGAAAVFERGDSVDNLSNARVANGDSH
3-keto-acyl-CoA thiolase 2
Refseq ID NP_001032037
Protein GI 79330284
UniProt ID Q570C8
mRNA ID NM_001036960
Length 457
RefSeq Status REVIEWED
MERAMERQKILLRHLNPVSSSNSSLKHEPSLLSPVNCVSEVSPMAAFGDDIVIVAAYRTAICKARRGGFKDTLPDDLLASVLKAVVERTSLDPSEVGDIVVGTVIAPGSQRAMECRVAAYFAGFPDSVPVRTVNRQCSSGLQAVADVAASIRAGYYDIGIGAGVESMSTDHIPGGGFHGSNPRAQDFPKARDCLLPMGITSENVAERFGVTREEQDMAAVESHKRAAAAIASGKLKDEIIPVATKIVDPETKAEKAIVVSVDDGVRPNSNMADLAKLKTVFKQNGSTTAGNASQISDGAGAVLLMKRSLAMKKGLPILGVFRSFAVTGVEPSVMGIGPAVAIPAATKLAGLNVSDIDLFEINEAFASQYVYSCKKLELDMEKVNVNGGAIAIGHPLGATGARCVATLLHEMKRRGKDCRFGVISMCIGTGMGAAAVFERGDSVDNLSNARVANGDSH
3-keto-acyl-CoA thiolase 2
Refseq ID NP_568704
Protein GI 30695564
UniProt ID Q570C8
mRNA ID NM_124265
Length 457
RefSeq Status REVIEWED
Protein sequence is identical to GI:79330284 (mRNA isoform)

Gene Information

Entrez Gene ID
834946
Gene Name
3-keto-acyl-CoA thiolase 2
Gene Symbol
PKT2
Species
Arabidopsis thaliana

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005777 IDA:TAIR C peroxisome
GO:0003988 IEA:UniProtKB-EC F acetyl-CoA C-acyltransferase activity
GO:0031408 IEA:UniProtKB-KW P oxylipin biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
ath01040 Biosynthesis of unsaturated fatty acids
ath_M00113 Jasmonic acid biosynthesis
ath04146 Peroxisome
ath_M00087 beta-Oxidation

Domain Information

InterPro Annotations

Accession Description
IPR002155 Thiolase
IPR020617 Thiolase, C-terminal
IPR020616 Thiolase, N-terminal
IPR020610 Thiolase, active site
IPR020615 Thiolase, acyl-enzyme intermediate active site
IPR020613 Thiolase, conserved site
IPR016039 Thiolase-like
IPR016038 Thiolase-like, subgroup

UniProt Annotations

Entry Information

Gene Name
3-keto-acyl-CoA thiolase 2
Protein Entry
THIK5_ARATH
UniProt ID
Q570C8
Species
Arabidopsis

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=PKT2; IsoId=Q570C8-1; Sequence=Displayed; Name=2; Synonyms=PKT1; IsoId=Q570C8-2; Sequence=VSP_015460;
Catalytic Activity Acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA.
Developmental Stage Slightly induced in leaves during senescence. {ECO:0000269|PubMed:11891244}.
Function Probably involved in long chain fatty-acid beta- oxidation prior to gluconeogenesis during germination and subsequent seedling growth. Involved in systemic jasmonic acid (JA) biosynthesis after wounding and may be during senescence. {ECO:0000269|PubMed:11696182, ECO:0000269|PubMed:15141068}.
Induction Induced by jasmonic acid (JA) and systemically by wounding. Slightly induced by dehydration. {ECO:0000269|PubMed:15141068}.
Pathway Lipid metabolism; fatty acid metabolism.
Similarity Belongs to the thiolase family. {ECO:0000305}.
Subcellular Location Peroxisome {ECO:0000305}.
Subunit Homodimer. {ECO:0000250}.
Tissue Specificity Expressed in seedlings and wounded leaves. {ECO:0000269|PubMed:11696182, ECO:0000269|PubMed:15141068}.

Identical and Related Proteins

Unique RefSeq proteins for LMP009712 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
79330284 RefSeq NP_001032037 457 3-keto-acyl-CoA thiolase 2
30695561 RefSeq NP_851157 414 3-keto-acyl-CoA thiolase 2

Identical Sequences to LMP009712 proteins

Reference Database Accession Length Protein Name
GI:79330284 GenBank AAO00649.1 457 Sequence 16 from patent US 6489461
GI:79330284 GenBank ACW85277.1 457 Sequence 1179 from patent US 7569389
GI:30695561 GenBank ACW85279.1 414 Sequence 1181 from patent US 7569389
GI:30695561 GenBank ACW86370.1 414 Sequence 2673 from patent US 7569389
GI:30695561 GenBank ACW86469.1 414 Sequence 2809 from patent US 7569389
GI:30695561 GenBank ACW88491.1 414 Sequence 5575 from patent US 7569389
GI:30695561 GenBank ADT60495.1 414 Sequence 1880 from patent US 7847156
GI:30695561 gnl TAIR 414 3-keto-acyl-CoA thiolase 2 [Arabidopsis thaliana]
GI:79330284 gnl TAIR 457 3-keto-acyl-CoA thiolase 2 [Arabidopsis thaliana]
GI:79330284 gnl TAIR 457 3-keto-acyl-CoA thiolase 2 [Arabidopsis thaliana]
GI:79330284 RefSeq NP_568704.2 457 3-keto-acyl-CoA thiolase 2 [Arabidopsis thaliana]
GI:79330284 SwissProt Q570C8.2 457 RecName: Full=3-ketoacyl-CoA thiolase 5, peroxisomal; AltName: Full=Acetyl-CoA acyltransferase 5; AltName: Full=Beta-ketothiolase 5; AltName: Full=Peroxisomal 3-oxoacyl-CoA thiolase 5; Flags: Precursor [Arabidopsis thaliana]

Related Sequences to LMP009712 proteins

Reference Database Accession Length Protein Name
GI:30695561 DBBJ BAB09441.1 457 3-keto-acyl-CoA thiolase 2 [Arabidopsis thaliana]
GI:30695561 GenBank AAC17877.1 457 3-keto-acyl-CoA thiolase 2 [Arabidopsis thaliana]
GI:30695561 GenBank AAC23571.1 457 peroxisomal 3-keto-acyl-CoA thiolase 2 precursor [Arabidopsis thaliana]
GI:30695561 GenBank AAO00649.1 457 Sequence 16 from patent US 6489461
GI:30695561 GenBank ACW85277.1 457 Sequence 1179 from patent US 7569389
GI:79330284 GenBank ACW85278.1 453 Sequence 1180 from patent US 7569389
GI:79330284 GenBank EFH41944.1 457 KAT5/PKT1/PKT2 peroxisomal 3-keto-acyl-CoA thiolase [Arabidopsis lyrata subsp. lyrata]
GI:79330284 GenBank EOA13339.1 457 hypothetical protein CARUB_v10026373mg [Capsella rubella]
GI:79330284 RefSeq XP_002865685.1 457 KAT5/PKT1/PKT2 peroxisomal 3-keto-acyl-CoA thiolase [Arabidopsis lyrata subsp. lyrata]
GI:79330284 RefSeq XP_006280441.1 457 hypothetical protein CARUB_v10026373mg [Capsella rubella]
GI:79330284 RefSeq XP_010439766.1 456 PREDICTED: 3-ketoacyl-CoA thiolase 5, peroxisomal isoform X1 [Camelina sativa]
GI:30695561 SwissProt Q570C8.2 457 RecName: Full=3-ketoacyl-CoA thiolase 5, peroxisomal; AltName: Full=Acetyl-CoA acyltransferase 5; AltName: Full=Beta-ketothiolase 5; AltName: Full=Peroxisomal 3-oxoacyl-CoA thiolase 5; Flags: Precursor [Arabidopsis thaliana]