Gene/Proteome Database (LMPD)

LMPD ID
LMP009746
Gene ID
841575
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
ABC transporter G family member 12
Gene Symbol
CER5
Synonyms
ABC TRANSPORTER FROM THE ABCG SUBFAMILY 12; ABCG12; ARABIDOPSIS THALIANA WHITE-BROWN COMPLEX 12; ATWBC12; CER5; D3; ECERIFERUM 5; F5D21.6; F5D21_6; WBC12; WHITE-BROWN COMPLEX 12
Alternate Names
ABC transporter G family member 12
Chromosome
1
Summary
Encodes an ABC transporter involved in cuticular wax biosynthesis. Lines carrying recessive mutations in this locus have weakly glaucous stem surface, and relative elevated secondary alcohols and ketones.
Orthologs
View orthologs and multiple alignments for CER5

Proteins

ABC transporter G family member 12
Refseq ID NP_175561
Protein GI 15217942
UniProt ID Q9C8K2
mRNA ID NM_104028
Length 687
RefSeq Status REVIEWED
MELESTSNGRRPPPPAEIGRGAYLAWEDLTVVIPNFSGGPTRRLLDGLNGHAEPGRIMAIMGPSGSGKSTLLDSLAGRLARNVIMTGNLLLNGKKARLDYGLVAYVTQEDILMGTLTVRETITYSAHLRLSSDLTKEEVNDIVEGTIIELGLQDCADRVIGNWHSRGVSGGERKRVSVALEILTRPQILFLDEPTSGLDSASAFFVIQALRNIARDGGRTVVSSIHQPSSEVFALFDDLFLLSSGETVYFGESKFAVEFFAEAGFPCPKKRNPSDHFLRCINSDFDTVTATLKGSQRIRETPATSDPLMNLATSEIKARLVENYRRSVYAKSAKSRIRELASIEGHHGMEVRKGSEATWFKQLRTLTKRSFVNMCRDIGYYWSRIVIYIVVSFCVGTIFYDVGHSYTSILARVSCGGFITGFMTFMSIGGFPSFIEEMKVFYKERLSGYYGVSVYIISNYVSSFPFLVAIALITGSITYNMVKFRPGVSHWAFFCLNIFFSVSVIESLMMVVASLVPNFLMGLITGAGIIGIIMMTSGFFRLLPDLPKVFWRYPISFMSYGSWAIQGAYKNDFLGLEFDPMFAGEPKMTGEQVINKIFGVQVTHSKWWDLSAIVLILVCYRILFFIVLKLKERAEPALKAIQAKRTMKSLKKRPSFKKVPSLSSLSSRRHQPLHSLSSQEGLTSPIN

Gene Information

Entrez Gene ID
841575
Gene Name
ABC transporter G family member 12
Gene Symbol
CER5
Species
Arabidopsis thaliana

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005886 IEA:UniProtKB-KW C plasma membrane
GO:0016887 IEA:InterPro F ATPase activity
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0006869 IEA:UniProtKB-KW P lipid transport
GO:0009737 IDA:UniProtKB P response to abscisic acid
GO:0009651 IDA:UniProtKB P response to salt stress
GO:0010025 IMP:TAIR P wax biosynthetic process

REACTOME Pathway Links

REACTOME Pathway ID Description
6254129 ABCA transporters in lipid homeostasis
6254130 ABC-family proteins mediated transport
6253965 Lipid digestion, mobilization, and transport
6254128 Trafficking of dietary sterols

Domain Information

InterPro Annotations

Accession Description
IPR003593 AAA+ ATPase domain
IPR013525 ABC-2 type transporter
IPR017871 ABC transporter, conserved site
IPR003439 ABC_transporter-like
IPR027417 P-loop containing nucleoside triphosphate hydrolase

UniProt Annotations

Entry Information

Gene Name
ABC transporter G family member 12
Protein Entry
AB12G_ARATH
UniProt ID
Q9C8K2
Species
Arabidopsis

Comments

Comment Type Description
Disruption Phenotype Abnormal cuticle and unusual lipidic cytoplasmatic inclusions in epidermal cells,. {ECO:0000269|PubMed:17951461}.
Function Involved in the secretion of cuticular wax from epidermal cells to the cuticle. {ECO:0000269|PubMed:11336252, ECO:0000269|PubMed:15499022, ECO:0000269|PubMed:17951461}.
Induction By NaCl and abscisic acid (ABA). {ECO:0000269|PubMed:17951461}.
Similarity Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily. {ECO:0000305}.
Similarity Contains 1 ABC transmembrane type-2 domain. {ECO:0000305}.
Similarity Contains 1 ABC transporter domain. {ECO:0000255|PROSITE-ProRule:PRU00434}.
Subcellular Location Cell membrane {ECO:0000269|PubMed:15499022}; Multi-pass membrane protein {ECO:0000269|PubMed:15499022}.
Tissue Specificity Exclusively and constitutively expressed in epidermal cells. {ECO:0000269|PubMed:15499022}.

Identical and Related Proteins

Unique RefSeq proteins for LMP009746 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
15217942 RefSeq NP_175561 687 ABC transporter G family member 12

Identical Sequences to LMP009746 proteins

Reference Database Accession Length Protein Name
GI:15217942 GenBank AEE32674.1 687 ABC transporter G family member 12 [Arabidopsis thaliana]
GI:15217942 GenBank AEJ67197.1 687 Sequence 23 from patent US 7968321
GI:15217942 GenBank AER79689.1 687 Sequence 23 from patent US 8048666
GI:15217942 GenBank AFO04171.1 687 Sequence 23 from patent US 8216816
GI:15217942 GenBank AGP21860.1 687 Sequence 23 from patent US 8465954
GI:15217942 GenBank AGV98486.1 687 Sequence 910 from patent US 8513488

Related Sequences to LMP009746 proteins

Reference Database Accession Length Protein Name
GI:15217942 GenBank EFH70579.1 687 hypothetical protein ARALYDRAFT_892122 [Arabidopsis lyrata subsp. lyrata]
GI:15217942 GenBank EOA39818.1 687 hypothetical protein CARUB_v10008484mg [Capsella rubella]
GI:15217942 RefSeq XP_002894320.1 687 hypothetical protein ARALYDRAFT_892122 [Arabidopsis lyrata subsp. lyrata]
GI:15217942 RefSeq XP_006306920.1 687 hypothetical protein CARUB_v10008484mg [Capsella rubella]
GI:15217942 RefSeq XP_010500724.1 686 PREDICTED: ABC transporter G family member 12-like [Camelina sativa]
GI:15217942 RefSeq XP_010461981.1 686 PREDICTED: ABC transporter G family member 12 [Camelina sativa]