Gene/Proteome Database (LMPD)

LMPD ID
LMP009747
Gene ID
838122
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
ABC transporter G family member 40
Gene Symbol
PDR12
Synonyms
ABCG40; ARABIDOPSIS THALIANA ATP-BINDING CASSETTE FAMILY G 40; ATABCG40; ATP-BINDING CASSETTE FAMILY G40; ATPDR12; PDR12; pleiotropic drug resistance 12; PLEIOTROPIC DRUG RESISTANCE 12; T16N11.3; T16N11_3
Alternate Names
ABC transporter G family member 40
Chromosome
1
Summary
ABC transporter family involved in ABA transport and resistance to lead. Localizes to plasma membrane. Upregulated by lead. Expressed in leaves, flowers, stomata and roots.
Orthologs
View orthologs and multiple alignments for PDR12

Proteins

ABC transporter G family member 40
Refseq ID NP_173005
Protein GI 15218218
UniProt ID Q9M9E1
mRNA ID NM_101421
Length 1423
RefSeq Status REVIEWED
MEGTSFHQASNSMRRNSSVWKKDSGREIFSRSSREEDDEEALRWAALEKLPTFDRLRKGILTASHAGGPINEIDIQKLGFQDTKKLLERLIKVGDDEHEKLLWKLKKRIDRVGIDLPTIEVRFDHLKVEAEVHVGGRALPTFVNFISNFADKFLNTLHLVPNRKKKFTILNDVSGIVKPGRMALLLGPPSSGKTTLLLALAGKLDQELKQTGRVTYNGHGMNEFVPQRTAAYIGQNDVHIGEMTVRETFAYAARFQGVGSRYDMLTELARREKEANIKPDPDIDIFMKAMSTAGEKTNVMTDYILKILGLEVCADTMVGDDMLRGISGGQKKRVTTGEMLVGPSRALFMDEISTGLDSSTTYQIVNSLRNYVHIFNGTALISLLQPAPETFNLFDDIILIAEGEIIYEGPRDHVVEFFETMGFKCPPRKGVADFLQEVTSKKDQMQYWARRDEPYRFIRVREFAEAFQSFHVGRRIGDELALPFDKTKSHPAALTTKKYGVGIKELVKTSFSREYLLMKRNSFVYYFKFGQLLVMAFLTMTLFFRTEMQKKTEVDGSLYTGALFFILMMLMFNGMSELSMTIAKLPVFYKQRDLLFYPAWVYSLPPWLLKIPISFMEAALTTFITYYVIGFDPNVGRLFKQYILLVLMNQMASALFKMVAALGRNMIVANTFGAFAMLVFFALGGVVLSRDDIKKWWIWGYWISPIMYGQNAILANEFFGHSWSRAVENSSETLGVTFLKSRGFLPHAYWYWIGTGALLGFVVLFNFGFTLALTFLNSLGKPQAVIAEEPASDETELQSARSEGVVEAGANKKRGMVLPFEPHSITFDNVVYSVDMPQEMIEQGTQEDRLVLLKGVNGAFRPGVLTALMGVSGAGKTTLMDVLAGRKTGGYIDGNITISGYPKNQQTFARISGYCEQTDIHSPHVTVYESLVYSAWLRLPKEVDKNKRKIFIEEVMELVELTPLRQALVGLPGESGLSTEQRKRLTIAVELVANPSIIFMDEPTSGLDARAAAIVMRTVRNTVDTGRTVVCTIHQPSIDIFEAFDELFLLKRGGEEIYVGPLGHESTHLINYFESIQGINKITEGYNPATWMLEVSTTSQEAALGVDFAQVYKNSELYKRNKELIKELSQPAPGSKDLYFPTQYSQSFLTQCMASLWKQHWSYWRNPPYTAVRFLFTIGIALMFGTMFWDLGGKTKTRQDLSNAMGSMYTAVLFLGLQNAASVQPVVNVERTVFYREQAAGMYSAMPYAFAQVFIEIPYVLVQAIVYGLIVYAMIGFEWTAVKFFWYLFFMYGSFLTFTFYGMMAVAMTPNHHIASVVSSAFYGIWNLFSGFLIPRPSMPVWWEWYYWLCPVAWTLYGLIASQFGDITEPMADSNMSVKQFIREFYGYREGFLGVVAAMNVIFPLLFAVIFAIGIKSFNFQKR

Gene Information

Entrez Gene ID
838122
Gene Name
ABC transporter G family member 40
Gene Symbol
PDR12
Species
Arabidopsis thaliana

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005886 IDA:TAIR C plasma membrane
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0016887 IEA:InterPro F ATPase activity
GO:0080168 IDA:TAIR P abscisic acid transport
GO:0006952 IEA:UniProtKB-KW P defense response
GO:0006855 ISS:TAIR P drug transmembrane transport
GO:0015692 IMP:TAIR P lead ion transport
GO:0009723 TAS:TAIR P response to ethylene
GO:0009753 TAS:TAIR P response to jasmonic acid
GO:0010193 IEP:TAIR P response to ozone
GO:0009751 TAS:TAIR P response to salicylic acid
GO:0046865 IDA:TAIR P terpenoid transport

Domain Information

InterPro Annotations

Accession Description
IPR003593 AAA+ ATPase domain
IPR013525 ABC-2 type transporter
IPR029481 ABC-transporter extracellular N-terminal domain
IPR003439 ABC_transporter-like
IPR027417 P-loop containing nucleoside triphosphate hydrolase
IPR013581 Plant PDR ABC transporter associated

UniProt Annotations

Entry Information

Gene Name
ABC transporter G family member 40
Protein Entry
AB40G_ARATH
UniProt ID
Q9M9E1
Species
Arabidopsis

Comments

Comment Type Description
Function May be a general defense protein (By similarity). Functions as a pump to exclude Pb(2+) ions and/or Pb(2+)- containing toxic compounds from the cytoplasm. Contributes to Pb(2+) ions resistance. Confers some resistance to the terpene sclareol. {ECO:0000250, ECO:0000269|PubMed:14526118, ECO:0000269|PubMed:15923333}.
Induction Circadian-regulation. Expression increase during the dark phase and decrease during the light phase. Induced by cycloheximide (CHX), sclareol, and heavy metals such as Pb(2+) ions. ETR1-, EIN2-, JAR1-, NPR1- and EDS5-dependent induction by incompatible fungal pathogens (A.brassicicola), by compatible fungal pathogens (S.sclerotiorum and F.oxysporum), and by compatible bacterial pathogens (P.syringae pv tomato). Also induced by phytohormones such as salicylic acid (SA), methyl jasmonate (MeJA) and ethylene. {ECO:0000269|PubMed:12430018, ECO:0000269|PubMed:14526118, ECO:0000269|PubMed:15923333}.
Similarity Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily. {ECO:0000305}.
Similarity Contains 2 ABC transmembrane type-2 domains. {ECO:0000305}.
Similarity Contains 2 ABC transporter domains. {ECO:0000255|PROSITE-ProRule:PRU00434}.
Subcellular Location Cell membrane {ECO:0000269|PubMed:15923333}; Multi-pass membrane protein {ECO:0000269|PubMed:15923333}.
Tissue Specificity Ubiquitous with higher levels in leaves, stems and flowers. {ECO:0000269|PubMed:12430018, ECO:0000269|PubMed:14526118, ECO:0000269|PubMed:15923333}.

Identical and Related Proteins

Unique RefSeq proteins for LMP009747 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
15218218 RefSeq NP_173005 1423 ABC transporter G family member 40

Identical Sequences to LMP009747 proteins

Reference Database Accession Length Protein Name
GI:15218218 EMBL CBD19743.1 1423 unnamed protein product [Arabidopsis thaliana]
GI:15218218 EMBL CBD23798.1 1423 unnamed protein product [Arabidopsis thaliana]
GI:15218218 EMBL CBD23884.1 1423 unnamed protein product [Arabidopsis thaliana]
GI:15218218 EMBL CBD26091.1 1423 unnamed protein product [Arabidopsis thaliana]
GI:15218218 EMBL CBD24010.1 1423 unnamed protein product [Arabidopsis thaliana]
GI:15218218 GenBank AEE29332.1 1423 ABC transporter G family member 40 [Arabidopsis thaliana]

Related Sequences to LMP009747 proteins

Reference Database Accession Length Protein Name
GI:15218218 GenBank EFH69130.1 1422 ATPDR12/PDR12 [Arabidopsis lyrata subsp. lyrata]
GI:15218218 RefSeq XP_002892871.1 1422 ATPDR12/PDR12 [Arabidopsis lyrata subsp. lyrata]
GI:15218218 RefSeq XP_010497221.1 1424 PREDICTED: ABC transporter G family member 40-like [Camelina sativa]
GI:15218218 RefSeq XP_010459089.1 1424 PREDICTED: ABC transporter G family member 40 isoform X1 [Camelina sativa]
GI:15218218 RefSeq XP_010459091.1 1436 PREDICTED: ABC transporter G family member 40 isoform X3 [Camelina sativa]
GI:15218218 RefSeq XP_010476642.1 1424 PREDICTED: ABC transporter G family member 40-like [Camelina sativa]