Gene/Proteome Database (LMPD)

LMPD ID
LMP009753
Gene ID
840521
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
acetyl-CoA carboxylase 1
Gene Symbol
ACC1
Synonyms
acetyl-CoA carboxylase 1; AT-ACC1; EMB22; EMBRYO DEFECTIVE 22; GK; GURKE; PAS3; PASTICCINO 3
Alternate Names
acetyl-CoA carboxylase 1
Chromosome
1
EC Number
6.4.1.2
Summary
Encodes acetyl-CoA carboxylase. Mutant displays uncoordinated cell divisions which are enhanced by cytokinins. Mutant also has aberrant organization of the apical region in the embryo and abnormal root and shoot development. Essential for very long chain fatty acid elongation.
Orthologs
View orthologs and multiple alignments for ACC1

Proteins

acetyl-CoA carboxylase 1
Refseq ID NP_001185143
Protein GI 334183050
UniProt ID Q38970
mRNA ID NM_001198214
Length 2254
RefSeq Status REVIEWED
MAGSVNGNHSAVGPGINYETVSQVDEFCKALRGKRPIHSILIANNGMAAVKFIRSVRTWAYETFGTEKAILLVGMATPEDMRINAEHIRIADQFVEVPGGTNNNNYANVQLIVEMAEVTRVDAVWPGWGHASENPELPDALDAKGIIFLGPPASSMAALGDKIGSSLIAQAADVPTLPWSGSHVKIPPNSNLVTIPEEIYRQACVYTTEEAIASCQVVGYPAMIKASWGGGGKGIRKVHNDDEVRALFKQVQGEVPGSPIFIMKVASQSRHLEVQLLCDKHGNVSALHSRDCSVQRRHQKIIEEGPITVAPPETVKKLEQAARRLAKSVNYVGAATVEYLYSMDTGEYYFLELNPRLQVEHPVTEWIAEINLPAAQVAVGMGIPLWQIPEIRRFYGIEHGGGYDSWRKTSVVAFPFDFDKAQSIRPKGHCVAVRVTSEDPDDGFKPTSGRVQELSFKSKPNVWAYFSVKSGGGIHEFSDSQFGHVFAFGESRALAIANMVLGLKEIQIRGEIRTNVDYTIDLLHASDYRDNKIHTGWLDSRIAMRVRAERPPWYLSVVGGALYKASATSAAVVSDYVGYLEKGQIPPKHISLVHSQVSLNIEGSKYTIDVVRGGSGTYRLRMNKSEVVAEIHTLRDGGLLMQLDGKSHVIYAEEEAAGTRLLIDGRTCLLQNDHDPSKLMAETPCKLMRYLISDNSNIDADTPYAEVEVMKMCMPLLSPASGVIHFKMSEGQAMQAGELIANLDLDDPSAVRKAEPFHGSFPRLGLPTAISGRVHQRCAATLNAARMILAGYEHKVDEVVQDLLNCLDSPELPFLQWQECFAVLATRLPKNLRNMLESKYREFESISRNSLTTDFPAKLLKGILEAHLSSCDEKERGALERLIEPLMSLAKSYEGGRESHARVIVHSLFEEYLSVEELFNDNMLADVIERMRQLYKKDLLKIVDIVLSHQGIKNKNKLVLRLMEQLVYPNPAAYRDKLIRFSTLNHTNYSELALKASQLLEQTKLSELRSNIARSLSELEMFTEDGENMDTPKRKSAINERIEDLVSASLAVEDALVGLFDHSDHTLQRRVVETYIRRLYQPYVVKDSVRMQWHRSGLLASWEFLEEHMERKNIGLDDPDTSEKGLVEKRSKRKWGAMVIIKSLQFLPSIISAALRETKHNDYETAGAPLSGNMMHIAIVGINNQMSLLQDSGDEDQAQERVNKLAKILKEEEVSSSLCSAGVGVISCIIQRDEGRTPMRHSFHWSLEKQYYVEEPLLRHLEPPLSIYLELDKLKGYSNIQYTPSRDRQWHLYTVTDKPVPIKRMFLRSLVRQATMNDGFILQQGQDKQLSQTLISMAFTSKCVLRSLMDAMEELELNAHNAAMKPDHAHMFLCILREQQIDDLVPFPRRVEVNAEDEETTVEMILEEAAREIHRSVGVRMHRLGVCEWEVRLWLVSSGLACGAWRVVVANVTGRTCTVHIYREVETPGRNSLIYHSITKKGPLHETPISDQYKPLGYLDRQRLAARRSNTTYCYDFPLAFGTALELLWASQHPGVKKPYKDTLINVKELVFSKPEGSSGTSLDLVERPPGLNDFGMVAWCLDMSTPEFPMGRKLLVIANDVTFKAGSFGPREDAFFLAVTELACAKKLPLIYLAANSGARLGVAEEVKACFKVGWSDEISPENGFQYIYLSPEDHERIGSSVIAHEVKLSSGETRWVIDTIVGKEDGIGVENLTGSGAIAGAYSKAYNETFTLTFVSGRTVGIGAYLARLGMRCIQRLDQPIILTGFSTLNKLLGREVYSSHMQLGGPKIMGTNGVVHLTVSDDLEGVSAILNWLSYIPAYVGGPLPVLAPLDPPERIVEYVPENSCDPRAAIAGVKDNTGKWLGGIFDKNSFIETLEGWARTVVTGRAKLGGIPVGVVAVETQTVMQIIPADPGQLDSHERVVPQAGQVWFPDSAAKTAQALMDFNREELPLFILANWRGFSGGQRDLFEGILQAGSTIVENLRTYRQPVFVYIPMMGELRGGAWVVVDSQINSDYVEMYADETARGNVLEPEGTIEIKFRTKELLECMGRLDQKLISLKAKLQDAKQSEAYANIELLQQQIKAREKQLLPVYIQIATKFAELHDTSMRMAAKGVIKSVVEWSGSRSFFYKKLNRRIAESSLVKNVREASGDNLAYKSSMRLIQDWFCNSDIAKGKEEAWTDDQVFFTWKDNVSNYELKLSELRAQKLLNQLAEIGNSSDLQALPQGLANLLNKVEPSKREELVAAIRKVLG
acetyl-CoA carboxylase 1
Refseq ID NP_174849
Protein GI 79358114
UniProt ID Q38970
mRNA ID NM_103313
Length 2254
RefSeq Status REVIEWED
Protein sequence is identical to GI:334183050 (mRNA isoform)

Gene Information

Entrez Gene ID
840521
Gene Name
acetyl-CoA carboxylase 1
Gene Symbol
ACC1
Species
Arabidopsis thaliana

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IEA:UniProtKB-KW C cytoplasm
GO:0005886 IDA:TAIR C plasma membrane
GO:0003989 ISS:TAIR F acetyl-CoA carboxylase activity
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0004075 IEA:UniProtKB-EC F biotin carboxylase activity
GO:0046872 IEA:UniProtKB-KW F metal ion binding
GO:0009793 IMP:TAIR P embryo development ending in seed dormancy
GO:0030497 IMP:TAIR P fatty acid elongation
GO:2001295 IEA:UniProtKB-UniPathway P malonyl-CoA biosynthetic process
GO:0009933 IMP:TAIR P meristem structural organization
GO:0010072 IMP:TAIR P primary shoot apical meristem specification
GO:0009735 IMP:TAIR P response to cytokinin
GO:0048364 IMP:TAIR P root development
GO:0048367 IMP:TAIR P shoot system development

KEGG Pathway Links

KEGG Pathway ID Description
ath00061 Fatty acid biosynthesis
ath_M00082 Fatty acid biosynthesis, initiation
ath00620 Pyruvate metabolism

REACTOME Pathway Links

REACTOME Pathway ID Description
6254406 Biotin transport and metabolism

Domain Information

InterPro Annotations

Accession Description
IPR013537 Acetyl-CoA carboxylase, central domain
IPR011763 Acetyl-coenzyme A carboxyltransferase, C-terminal
IPR011762 Acetyl-coenzyme A carboxyltransferase, N-terminal
IPR011761 ATP-grasp fold
IPR013815 ATP-grasp fold, subdomain 1
IPR013816 ATP-grasp fold, subdomain 2
IPR001882 Biotin-binding site
IPR005482 Biotin carboxylase, C-terminal
IPR011764 Biotin carboxylation domain
IPR000089 Biotin/lipoyl attachment
IPR005481 Carbamoyl-phosphate synthase, large subunit, N-terminal
IPR005479 Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain
IPR000022 Carboxyl transferase
IPR029045 ClpP/crotonase-like domain
IPR016185 Pre-ATP-grasp domain
IPR011054 Rudiment single hybrid motif
IPR011053 Single hybrid motif

UniProt Annotations

Entry Information

Gene Name
acetyl-CoA carboxylase 1
Protein Entry
ACC1_ARATH
UniProt ID
Q38970
Species
Arabidopsis

Comments

Comment Type Description
Catalytic Activity ATP + acetyl-CoA + HCO(3)(-) = ADP + phosphate + malonyl-CoA.
Catalytic Activity ATP + biotin-[carboxyl-carrier-protein] + CO(2) = ADP + phosphate + carboxy-biotin-[carboxyl-carrier- protein].
Cofactor Name=biotin; Xref=ChEBI:CHEBI:57586; Evidence={ECO:0000250}; Note=Biotin. {ECO:0000250};
Cofactor Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250}; Note=Binds 2 magnesium or manganese ions per subunit. {ECO:0000250};
Developmental Stage Expressed in flower buds at stage 6 of development in tapetal cells and at stage 10 in the epidermal cells of growing petals and ovaries. In young siliques, expressed transiently in the inner integument of the ovules just prior to testal deposition. {ECO:0000269|PubMed:12376641}.
Disruption Phenotype Embryo lethal with an arrest in development at the late globular stage in acc1-1 and acc1-2 null allele mutants. In the leaky pas3 and gk alleles, defect in embryo development, very short and thick hypocotyl and misshaped cotyledons that do not expand. Abnormal root development, abnormal fused leaves and compact rosettes with multiple shoots. Uncoordinated cell divisions in the apical region. Reduced levels of very long chain fatty acids in seeds. {ECO:0000269|PubMed:12943542, ECO:0000269|PubMed:15088065, ECO:0000269|PubMed:15509834, ECO:0000269|PubMed:9011083, ECO:0000269|PubMed:9449673}.
Function Multifunctional enzyme that catalyzes the carboxylation of acetyl-CoA, forming malonyl-CoA, which is used in the plastid for fatty acid synthesis and in the cytosol in various biosynthetic pathways including fatty acid elongation. Required for very long chain fatty acids elongation. Necessary for embryo and plant development. Plays a central function in embryo morphogenesis, especially in apical meristem development. Involved in cell proliferation and tissue patterning. May act as a repressor of cytokinin response. {ECO:0000269|PubMed:12943542, ECO:0000269|PubMed:15088065, ECO:0000269|PubMed:15509834, ECO:0000269|PubMed:20145257, ECO:0000269|PubMed:9008389, ECO:0000269|PubMed:9449673}.
Miscellaneous The acc1-1 and pas3-1 mutants can be partially complemented by exogenous supply of malonate.
Pathway Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.
Sequence Caution Sequence=AAF18638.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAG51250.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Similarity Contains 1 ATP-grasp domain. {ECO:0000255|PROSITE- ProRule:PRU00409}.
Similarity Contains 1 biotin carboxylation domain. {ECO:0000305}.
Similarity Contains 1 biotinyl-binding domain. {ECO:0000255|PROSITE-ProRule:PRU01066, ECO:0000305}.
Similarity Contains 1 carboxyltransferase domain. {ECO:0000305}.
Subcellular Location Cytoplasm, cytosol {ECO:0000305}.
Subunit Homodimer. {ECO:0000305}.
Tissue Specificity Expressed in roots, trichomes, epidermal leaf cells, siliques, petals, anthers, and seeds. {ECO:0000269|PubMed:12376641, ECO:0000269|PubMed:12943542, ECO:0000269|PubMed:7551584, ECO:0000269|PubMed:7915036}.

Identical and Related Proteins

Unique RefSeq proteins for LMP009753 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
334183050 RefSeq NP_001185143 2254 acetyl-CoA carboxylase 1

Identical Sequences to LMP009753 proteins

Reference Database Accession Length Protein Name
GI:334183050 DBBJ BAA07012.1 2254 acetyl-CoA carboxylase [Arabidopsis thaliana]
GI:334183050 GenBank AEE31849.1 2254 acetyl-CoA carboxylase 1 [Arabidopsis thaliana]
GI:334183050 GenBank AEE31850.1 2254 acetyl-CoA carboxylase 1 [Arabidopsis thaliana]
GI:334183050 RefSeq NP_174849.2 2254 acetyl-CoA carboxylase 1 [Arabidopsis thaliana]
GI:334183050 SwissProt Q38970.1 2254 RecName: Full=Acetyl-CoA carboxylase 1; Short=AtACC1; AltName: Full=Protein EMBRYO DEFECTIVE 22; AltName: Full=Protein GURKE; AltName: Full=Protein PASTICCINO 3; Includes: RecName: Full=Biotin carboxylase [Arabidopsis thaliana]

Related Sequences to LMP009753 proteins

Reference Database Accession Length Protein Name
GI:334183050 EMBL CBF64161.1 2254 unnamed protein product [Arabidopsis thaliana]
GI:334183050 EMBL CBF60099.1 2254 unnamed protein product [Arabidopsis thaliana]
GI:334183050 EMBL CBF60839.1 2254 unnamed protein product [Arabidopsis thaliana]
GI:334183050 EMBL CBF61980.1 2254 unnamed protein product [Arabidopsis thaliana]
GI:334183050 EMBL CBF68375.1 2254 unnamed protein product [Arabidopsis thaliana]
GI:334183050 EMBL CBF95625.1 2254 unnamed protein product [Arabidopsis thaliana]