Gene/Proteome Database (LMPD)

LMPD ID
LMP009755
Gene ID
818382
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha
Gene Symbol
CAC3
Synonyms
acetyl Co-enzyme a carboxylase carboxyltransferase alpha subunit; CAC3; CARBOXYLTRANSFERASE ALPHA SUBUNIT; T8P21.5; T8P21_5
Alternate Names
acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha
Chromosome
2
EC Number
6.4.1.2
Summary
encodes the carboxyltransferase alpha subunit of acetyl-CoA carboxylase, involved in de novo fatty acid biosynthesis
Orthologs
View orthologs and multiple alignments for CAC3

Proteins

acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha
Refseq ID NP_565880
Protein GI 18404621
UniProt ID Q9LD43
mRNA ID NM_129360
Length 769
RefSeq Status REVIEWED
MASISHSSLALGGASSASASDYLRSSSNGVNGVPLKTLGRAVFTTIRRKDLAVTSRLKKGKKFEHPWPANPDPNVKGGVLSYLAEFKPLGDTQKPVTLDFEKPLVELEKKIVDVRKMANETGLDFTEQIITLENKYRQALKDLYTHLTPIQRVNIARHPNRPTFLDHIHNITDKFMELHGDRAGYDDPAIVTGIGTIDGKRYMFIGHQKGRNTKENIMRNFGMPTPHGYRKALRMMYYADHHGFPIVTFIDTPGAYADLKSEELGQGEAIANNLRTMFGLKVPILSIVIGEGGSGGALAIGCANKMLMLENAVFYVASPEACAAILWKTSKAAPEAAEKLRITSKELVKLNVADGIIPEPLGGAHADPSWTSQQIKIAINENMNEFGKMSGEELLKHRMAKYRKIGVFIEGEPIEPSRKINMKKREAVFSDSRKLQGEVDKLKEQILKAKETSTEAEPSSEVLNEMIEKLKSEIDDEYTEAAIAVGLEERLTAMREEFSKASSEEHLMHPVLIEKIEKLKEEFNTRLTDAPNYESLKSKLNMLRDFSRAKAASEATSLKKEINKRFQEAVDRPEIREKVEAIKAEVASSGASSFDELPDALKEKVLKTKGEVEAEMAGVLKSMGLELDAVKQNQKDTAEQIYAANENLQEKLEKLNQEITSKIEEVVRTPEIKSMVELLKVETAKASKTPGVTEAYQKIEALEQQIKQKIAEALNTSGLQEKQDELEKELAAARELAAEESDGSVKEDDDDDEDSSESGKSEMVNPSFA
acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha
Refseq ID NP_850291
Protein GI 30687368
UniProt ID Q9LD43
mRNA ID NM_179960
Length 769
RefSeq Status REVIEWED
Protein sequence is identical to GI:18404621 (mRNA isoform)

Gene Information

Entrez Gene ID
818382
Gene Name
acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha
Gene Symbol
CAC3
Species
Arabidopsis thaliana

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0009317 IEA:InterPro C acetyl-CoA carboxylase complex
GO:0009507 IDA:TAIR C chloroplast
GO:0009941 IDA:TAIR C chloroplast envelope
GO:0009570 IDA:TAIR C chloroplast stroma
GO:0016020 IDA:TAIR C membrane
GO:0009536 IDA:TAIR C plastid
GO:0009528 IEA:UniProtKB-KW C plastid inner membrane
GO:0003989 IEA:UniProtKB-EC F acetyl-CoA carboxylase activity
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0006633 IEA:UniProtKB-KW P fatty acid biosynthetic process
GO:2001295 IEA:UniProtKB-UniPathway P malonyl-CoA biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
ath01200 Carbon metabolism
ath00061 Fatty acid biosynthesis
ath_M00082 Fatty acid biosynthesis, initiation
ath00620 Pyruvate metabolism

Domain Information

InterPro Annotations

Accession Description
IPR001095 Acetyl-CoA carboxylase, alpha subunit
IPR011763 Acetyl-coenzyme A carboxyltransferase, C-terminal
IPR029045 ClpP/crotonase-like domain

UniProt Annotations

Entry Information

Gene Name
acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha
Protein Entry
ACCA_ARATH
UniProt ID
Q9LD43
Species
Arabidopsis

Comments

Comment Type Description
Catalytic Activity ATP + acetyl-CoA + HCO(3)(-) = ADP + phosphate + malonyl-CoA.
Function Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity). {ECO:0000250}.
Pathway Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.
Similarity Belongs to the AccA family. {ECO:0000305}.
Subcellular Location Plastid, chloroplast inner membrane {ECO:0000269|PubMed:10759501, ECO:0000269|PubMed:12766230, ECO:0000269|PubMed:12938931, ECO:0000269|PubMed:15028209, ECO:0000269|PubMed:16207701, ECO:0000269|PubMed:18431481}; Peripheral membrane protein {ECO:0000269|PubMed:10759501, ECO:0000269|PubMed:12766230, ECO:0000269|PubMed:12938931, ECO:0000269|PubMed:15028209, ECO:0000269|PubMed:16207701, ECO:0000269|PubMed:18431481}; Stromal side {ECO:0000269|PubMed:10759501, ECO:0000269|PubMed:12766230, ECO:0000269|PubMed:12938931, ECO:0000269|PubMed:15028209, ECO:0000269|PubMed:16207701, ECO:0000269|PubMed:18431481}.
Subunit Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein, biotin carboxylase and two subunits each of ACCase subunit alpha and ACCase plastid-coded subunit beta (accD). {ECO:0000269|PubMed:10759501}.
Tissue Specificity Accumulates in fatty acids synthesizing tissues such as embryos, expanding leaves, flower buds, flowers, and developing siliques. {ECO:0000269|PubMed:10759501}.

Identical and Related Proteins

Unique RefSeq proteins for LMP009755 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
18404621 RefSeq NP_565880 769 acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha

Identical Sequences to LMP009755 proteins

Reference Database Accession Length Protein Name
GI:18404621 GenBank AAF29414.1 769 carboxyltransferase alpha subunit [Arabidopsis thaliana]
GI:18404621 GenBank AAF29415.1 769 carboxyltransferase alpha subunit [Arabidopsis thaliana]
GI:18404621 GenBank AEC09482.1 769 acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha [Arabidopsis thaliana]
GI:18404621 GenBank AEC09483.1 769 acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha [Arabidopsis thaliana]
GI:18404621 RefSeq NP_850291.1 769 acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha [Arabidopsis thaliana]
GI:18404621 SwissProt Q9LD43.1 769 RecName: Full=Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha, chloroplastic; Short=ACCase subunit alpha; Short=Acetyl-CoA carboxylase carboxyltransferase subunit alpha; Flags: Precursor [Arabidopsis thaliana]

Related Sequences to LMP009755 proteins

Reference Database Accession Length Protein Name
GI:18404621 DBBJ BAD93727.1 769 carboxyltransferase alpha subunit [Arabidopsis thaliana]
GI:18404621 GenBank EOA26263.1 770 hypothetical protein CARUB_v10022686mg [Capsella rubella]
GI:18404621 RefSeq XP_006293365.1 770 hypothetical protein CARUB_v10022686mg [Capsella rubella]
GI:18404621 RefSeq XP_010505415.1 770 PREDICTED: acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha, chloroplastic [Camelina sativa]
GI:18404621 RefSeq XP_010509234.1 774 PREDICTED: acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha, chloroplastic-like [Camelina sativa]
GI:18404621 RefSeq XP_010517088.1 770 PREDICTED: acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha, chloroplastic-like [Camelina sativa]