Gene/Proteome Database (LMPD)

LMPD ID
LMP009800
Gene ID
831171
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
ADP-ribosylation factor GTPase-activating protein AGD3
Gene Symbol
SFC
Synonyms
AGD3; ARF-GAP DOMAIN3; ASCULAR NETWORK DEFECTIVE 3; SCARFACE; SFC; T31B5.120; T31B5_120; VAN3
Alternate Names
ADP-ribosylation factor GTPase-activating protein AGD3
Chromosome
5

Proteins

ADP-ribosylation factor GTPase-activating protein AGD3
Refseq ID NP_196834
Protein GI 79512687
UniProt ID Q5W7F2
mRNA ID NM_121333
Length 827
RefSeq Status REVIEWED
MHFTKLDDSPMFRKQLQSMEESAEILRERSLKFYKGCRKYTEGLGEAYDGDIAFASALETFGGGHNDPISVAFGGPVMTKFTIALREIGTYKEVLRSQVEHILNDRLLQFANMDLHEVKEARKRFDKASLTYDQAREKFLSLRKGTKSDVAAALEQELHTSRSMFEQARFNLVTALSNVEAKKRFEFLEAVSGTMDAHLRYFKQGYELLHQMEPYINQVLTYAQQSRERSNYEQAALNEKMQEYKRQVDRESRWGSNGSNGSPNGDGIQAIGRSSHKMIDAVMQSAARGKVQTIRQGYLSKRSSNLRGDWKRRFFVLDSRGMLYYYRKQCSKPSGSGSQLSGQRNSSELGSGLLSRWLSSNNHGHGGVHDEKSVARHTVNLLTSTIKVDADQSDLRFCFRIISPTKNYTLQAESALDQMDWIEKITGVIASLLSSQVPEQRLPGSPMGSGHHRSASESSSYESSEYDHPTTEEFVCERSFLGYNERPSRSFQPQRSIRKGEKPIDALRKVCGNDKCADCGAPEPDWASLNLGVLVCIECSGVHRNLGVHISKVRSLTLDVKVWEPSVISLFQALGNTFANTVWEELLHSRSAIHFDPGLTVSDKSRVMVTGKPSYADMISIKEKYIQAKYAEKLFVRRSRDSDFPQSAAQQMWDAVSGNDKKAVYRLIVNGDADVNYVYDQTSSSSLTLSRVILVPERPKREDVLLRLRNELLDRTGSSSNISPEGSGGSSLLHCACEKADLGMVELLLQYGANVNASDSSGQTPLHCCLLRGKVTIARLLLTRGADPEAMNREGKTALDIAAESNFTDPEVLALLSDTNGYNHRQC

Gene Information

Entrez Gene ID
831171
Gene Name
ADP-ribosylation factor GTPase-activating protein AGD3
Gene Symbol
SFC
Species
Arabidopsis thaliana

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005829 IDA:TAIR C cytosol
GO:0005886 IDA:TAIR C plasma membrane
GO:0030140 IDA:TAIR C trans-Golgi network transport vesicle
GO:0008060 IDA:TAIR F ARF GTPase activator activity
GO:0035091 IDA:TAIR F phosphatidylinositol binding
GO:0008270 IEA:InterPro F zinc ion binding
GO:0006897 IMP:TAIR P endocytosis
GO:0009965 IMP:TAIR P leaf morphogenesis
GO:0010087 IMP:TAIR P phloem or xylem histogenesis
GO:0043547 IDA:GOC P positive regulation of GTPase activity
GO:0032312 IEA:InterPro P regulation of ARF GTPase activity
GO:0009733 IMP:TAIR P response to auxin
GO:0010051 IMP:TAIR P xylem and phloem pattern formation

KEGG Pathway Links

KEGG Pathway ID Description
ath04144 Endocytosis
ko04144 Endocytosis

Domain Information

InterPro Annotations

Accession Description
IPR002110 Ankyrin repeat
IPR020683 Ankyrin repeat-containing domain
IPR027267 Arfaptin homology (AH) domain/BAR domain
IPR001164 Arf GTPase activating protein
IPR004148 BAR domain
IPR001849 Pleckstrin homology domain
IPR011993 Pleckstrin homology-like domain

UniProt Annotations

Entry Information

Gene Name
ADP-ribosylation factor GTPase-activating protein AGD3
Protein Entry
AGD3_ARATH
UniProt ID
Q5W7F2
Species
Arabidopsis

Comments

Comment Type Description
Domain The BAR domain is required and sufficient for homodimerization.
Function GTPase-activating protein (GAP) for ADP ribosylation factor (ARF). Involved in the spatial control of provascular differentiation. Required for the formation of the normal pattern of continuous secondary veins. Involved in auxin signaling but not in polar auxin transport or in auxin responses. Required for PIN1 internalization in roots. {ECO:0000269|PubMed:10887076, ECO:0000269|PubMed:10887077, ECO:0000269|PubMed:15743878, ECO:0000269|PubMed:16698946}.
Induction Up-regulated by auxin. {ECO:0000269|PubMed:15743878}.
Interaction P42697:DRP1A; NbExp=4; IntAct=EBI-994222, EBI-994234;
Miscellaneous Binds to phosphatidylinositol (PI), phosphatidylinositol 4-monophosphate (PIP) and phosphatidylinositol 4,5-bisphosphate (PIP2) but not to phosphatidic acid (PA), phosphatidylcholine (PC) or phosphatidylethanolamine (PE).
Sequence Caution Sequence=CAB86637.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Similarity Contains 1 Arf-GAP domain. {ECO:0000255|PROSITE- ProRule:PRU00288}.
Similarity Contains 1 BAR domain. {ECO:0000305}.
Similarity Contains 1 PH domain. {ECO:0000255|PROSITE- ProRule:PRU00145}.
Similarity Contains 3 ANK repeats. {ECO:0000255|PROSITE- ProRule:PRU00023}.
Subcellular Location Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:15743878}.
Subunit Homodimer. Interacts with DRP1A. {ECO:0000269|PubMed:15743878, ECO:0000269|PubMed:15923323}.
Tissue Specificity Detected in roots, hypocotyls, cotyledons, leaves, siliques and shoot apical meristems. {ECO:0000269|PubMed:16698946}.

Identical and Related Proteins

Unique RefSeq proteins for LMP009800 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
79512687 RefSeq NP_196834 827 ADP-ribosylation factor GTPase-activating protein AGD3

Identical Sequences to LMP009800 proteins

Reference Database Accession Length Protein Name
GI:79512687 DBBJ BAD69588.1 827 ARF-GAP [Arabidopsis thaliana]
GI:79512687 gnl TAIR 827 ADP-ribosylation factor GTPase-activating protein AGD3 [Arabidopsis thaliana]
GI:79512687 SwissProt Q5W7F2.1 827 RecName: Full=ADP-ribosylation factor GTPase-activating protein AGD3; Short=ARF GAP AGD3; AltName: Full=Protein ARF-GAP DOMAIN 3; Short=AtAGD3; AltName: Full=Protein SCARFACE; AltName: Full=Protein VASCULAR NETWORK 3 [Arabidopsis thaliana]

Related Sequences to LMP009800 proteins

Reference Database Accession Length Protein Name
GI:79512687 GenBank EFH49866.1 828 hypothetical protein ARALYDRAFT_488148 [Arabidopsis lyrata subsp. lyrata]
GI:79512687 GenBank EOA19969.1 824 hypothetical protein CARUB_v10000234mg [Capsella rubella]
GI:79512687 RefSeq XP_002873607.1 828 hypothetical protein ARALYDRAFT_488148 [Arabidopsis lyrata subsp. lyrata]
GI:79512687 RefSeq XP_010419904.1 829 PREDICTED: ADP-ribosylation factor GTPase-activating protein AGD3-like [Camelina sativa]
GI:79512687 RefSeq XP_010453391.1 829 PREDICTED: ADP-ribosylation factor GTPase-activating protein AGD3-like isoform X1 [Camelina sativa]
GI:79512687 RefSeq XP_010492078.1 829 PREDICTED: ADP-ribosylation factor GTPase-activating protein AGD3 [Camelina sativa]