Gene/Proteome Database (LMPD)

LMPD ID
LMP009863
Gene ID
832341
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
AP-2 complex subunit alpha-2
Gene Symbol
AT5G22780
Synonyms
K5A21.2; K5A21_2
Alternate Names
AP-2 complex subunit alpha-2
Chromosome
5

Proteins

AP-2 complex subunit alpha-2
Refseq ID NP_197670
Protein GI 15242964
UniProt ID Q8LPK4
mRNA ID NM_122184
Length 1013
RefSeq Status REVIEWED
MTGMRGLSVFISDVRNCQNKEAERLRVDKELGNIRTCFKNEKVLTPYKKKKYVWKMLYIHMLGYDVDFGHMEAVSLISAPKYPEKQVGYIVTSCLLNENHDFLKLAINTVRNDIIGRNETFQCLALTLVGNIGGRDFAESLAPDVQKLLISSSCRPLVRKKAALCLLRLFRKNPDAVNVDGWADRMAQLLDERDLGVLTSSTSLLVALVSNNHEAYSSCLPKCVKILERLARNQDVPQEYTYYGIPSPWLQVKAMRALQYFPTIEDPSTRKALFEVLQRILMGTDVVKNVNKNNASHAVLFEALSLVMHLDAEKEMMSQCVALLGKFISVREPNIRYLGLENMTRMLMVTDVQDIIKKHQSQIITSLKDPDISIRRRALDLLYGMCDVSNAKDIVEELLQYLSTAEFSMREELSLKAAILAEKFAPDLSWYVDVILQLIDKAGDFVSDDIWFRVVQFVTNNEDLQPYAASKAREYMDKIAIHETMVKVSAYILGEYGHLLARQPGCSASELFSILHEKLPTVSTPTIPILLSTYAKLLMHAQPPDPELQKKVWAVFKKYESCIDVEIQQRAVEYFELSKKGPAFMDVLAEMPKFPERQSSLIKKAENVEDTADQSAIKLRAQQQPSNAIVLADPQPVNGAPPPLKVPILSGSTDPESVARSLSHPNGTLSNIDPQTPSPDLLSDLLGPLAIEAPPGAVSYEQHGPVGAEGVPDEIDGSAIVPVEEQTNTVELIGNIAERFHALCLKDSGVLYEDPHIQIGIKAEWRGHHGRLVLFMGNKNTSPLTSVQALILPPAHLRLDLSPVPDTIPPRAQVQSPLEVMNIRPSRDVAVLDFSYKFGTNVVSAKLRIPATLNKFLQPLQLTSEEFFPQWRAISGPPLKLQEVVRGVRPLALPEMANLFNSFHVTICPGLDPNPNNLVASTTFYSETTGAMLCLARIETDPADRTQLRLTVGSGDPTLTFELKEFIKEQLITIPMGSRALVPAAGPAPSPAVQPPSPAALADDPGAMLAGLL

Gene Information

Entrez Gene ID
832341
Gene Name
AP-2 complex subunit alpha-2
Gene Symbol
AT5G22780
Species
Arabidopsis thaliana

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0030131 IEA:InterPro C clathrin adaptor complex
GO:0005905 IEA:UniProtKB-KW C coated pit
GO:0005886 IDA:TAIR C plasma membrane
GO:0008289 IEA:UniProtKB-KW F lipid binding
GO:0008565 IEA:InterPro F protein transporter activity
GO:0006897 IEA:UniProtKB-KW P endocytosis
GO:0006886 IEA:InterPro P intracellular protein transport

KEGG Pathway Links

KEGG Pathway ID Description
ath04144 Endocytosis
ko04144 Endocytosis

Domain Information

InterPro Annotations

Accession Description
IPR017104 Adaptor protein complex AP-2, alpha subunit
IPR011989 Armadillo-like helical
IPR016024 Armadillo-type fold
IPR003164 Clathrin adaptor, alpha-adaptin, appendage, C-terminal subdomain
IPR013038 Clathrin adaptor, alpha-adaptin, appendage, Ig-like subdomain
IPR008152 Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain
IPR015873 Clathrin alpha-adaptin/coatomer adaptor, appendage, C-terminal subdomain
IPR002553 Clathrin/coatomer adaptor, adaptin-like, N-terminal
IPR009028 Coatomer/calthrin adaptor appendage, C-terminal subdomain
IPR013041 Coatomer/clathrin adaptor appendage, Ig-like subdomain

UniProt Annotations

Entry Information

Gene Name
AP-2 complex subunit alpha-2
Protein Entry
AP2A2_ARATH
UniProt ID
Q8LPK4
Species
Arabidopsis

Comments

Comment Type Description
Function Subunit of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The complex binds polyphosphoinositides. {ECO:0000269|PubMed:15054111}.
Interaction Q9ZVN6:AP180; NbExp=2; IntAct=EBI-2366827, EBI-2366853;
Sequence Caution Sequence=BAB10137.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Similarity Belongs to the adaptor complexes large subunit family. {ECO:0000305}.
Similarity Contains 1 GAE domain. {ECO:0000305}.
Similarity Contains 4 HEAT repeats. {ECO:0000305}.
Subcellular Location Cell membrane {ECO:0000269|PubMed:15574830, ECO:0000269|PubMed:17644812}. Membrane, coated pit {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles in the plasma membrane. {ECO:0000250}.
Subunit Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type and beta-type subunits), a medium adaptin (mu-type subunit) and a small adaptin (sigma-type subunit) (By similarity). Interacts with AP180. {ECO:0000250, ECO:0000269|PubMed:15054111}.

Identical and Related Proteins

Unique RefSeq proteins for LMP009863 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
15242964 RefSeq NP_197670 1013 AP-2 complex subunit alpha-2

Identical Sequences to LMP009863 proteins

Reference Database Accession Length Protein Name
GI:15242964 GenBank AAM20497.1 1013 alpha-adaptin C-like protein [Arabidopsis thaliana]
GI:15242964 gnl TAIR 1013 AP-2 complex subunit alpha-2 [Arabidopsis thaliana]
GI:15242964 SwissProt Q8LPK4.1 1013 RecName: Full=AP-2 complex subunit alpha-2; AltName: Full=Adaptor protein complex AP-2 subunit alpha-2; AltName: Full=Adaptor-related protein complex 2 subunit alpha-2; AltName: Full=Alpha-adaptin 2; AltName: Full=Clathrin assembly protein complex 2 alpha-C large chain; Short=At-aC-Ad; Short=At-alphaC-Ad [Arabidopsis thaliana]

Related Sequences to LMP009863 proteins

Reference Database Accession Length Protein Name
GI:15242964 DBBJ BAB10137.1 1037 alpha-adaptin C homolog [Arabidopsis thaliana]
GI:15242964 GenBank AAM20420.1 1012 alpha-adaptin [Arabidopsis thaliana]
GI:15242964 gnl TAIR 1012 alpha-adaptin [Arabidopsis thaliana]
GI:15242964 gnl TAIR 1012 alpha-adaptin [Arabidopsis thaliana]
GI:15242964 RefSeq NP_197669.1 1012 alpha-adaptin [Arabidopsis thaliana]
GI:15242964 SwissProt Q8LPL6.1 1012 RecName: Full=AP-2 complex subunit alpha-1; AltName: Full=Adaptor protein complex AP-2 subunit alpha-1; AltName: Full=Adaptor-related protein complex 2 subunit alpha-1; AltName: Full=Alpha-adaptin 1; AltName: Full=Clathrin assembly protein complex 2 alpha large chain 1; Short=At-a-Ad; Short=At-alpha-Ad [Arabidopsis thaliana]