Gene/Proteome Database (LMPD)

LMPD ID
LMP009879
Gene ID
842375
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
ATP-citrate lyase A-2
Gene Symbol
ACLA-2
Synonyms
ATP-citrate lyase A-2; F8A5.32; F8A5_32
Alternate Names
ATP-citrate lyase A-2
Chromosome
1
EC Number
2.3.3.8
Summary
One of the three genes encoding subunit A of the trimeric enzyme ATP Citrate lyase
Orthologs
View orthologs and multiple alignments for ACLA-2

Proteins

ATP-citrate lyase A-2
Refseq ID NP_176280
Protein GI 15219818
UniProt ID O22718
mRNA ID NM_104764
Length 423
RefSeq Status REVIEWED
MARKKIREYDSKRLVKEHFKRLSGQELPIRSVQINQETDLNELVEREPWLSSEKLVVKPDMLFGKRGKSGLVALNLDFADVATFVKERLGKEVEMSGCKGPITTFIVEPFVPHNEEFYLNIVSDRLGCSISFSECGGIDIEENWDKVKTITIPTGASLTFEICAPLVATLPLEIKGELEDFIQVIFTLFEDLDFTFLEMNPFTLVDGKPYPLDMRGELDDTAAFKNFKKWGDIEFPMPFGRVMSSTESFIHGLDEKTSASLKFTVLNPKGRIWTMVAGGGASVIYADTVGDLGYASELGNYAEYSGAPKEDEVLQYARVVIDCATANPDGKSRALVIGGGIANFTDVAATFNGIIRALKEKEAKLKAARMHIFVRRGGPNYQKGLAKMRSLGDEIGVPIEVYGPEATMTGICKEAIQYITAAA

Gene Information

Entrez Gene ID
842375
Gene Name
ATP-citrate lyase A-2
Gene Symbol
ACLA-2
Species
Arabidopsis thaliana

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0009346 ISS:TAIR C citrate lyase complex
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0003878 ISS:TAIR F ATP citrate synthase activity
GO:0006085 TAS:TAIR P acetyl-CoA biosynthetic process
GO:0006629 IEA:UniProtKB-KW P lipid metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
ath01110 Biosynthesis of secondary metabolites
ath00020 Citrate cycle (TCA cycle)
ath01100 Metabolic pathways

REACTOME Pathway Links

REACTOME Pathway ID Description
6253967 ChREBP activates metabolic gene expression

Domain Information

InterPro Annotations

Accession Description
IPR013816 ATP-grasp fold, subdomain 2
IPR013650 ATP-grasp fold, succinyl-CoA synthetase-type
IPR016102 Succinyl-CoA synthetase-like

UniProt Annotations

Entry Information

Gene Name
ATP-citrate lyase A-2
Protein Entry
ACLA2_ARATH
UniProt ID
O22718
Species
Arabidopsis

Comments

Comment Type Description
Catalytic Activity ADP + phosphate + acetyl-CoA + oxaloacetate = ATP + citrate + CoA.
Function ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA, used for the elongation of fatty acids and biosynthesis of isoprenoids, flavonoids and malonated derivatives. May supply substrate to the cytosolic acetyl-CoA carboxylase, which generates the malonyl-CoA used for the synthesis of a multitude of compounds, including very long chain fatty acids and flavonoids. Required for normal growth and development and elongation of C18 fatty acids to C20 to C24 fatty acids in seeds. In contrast to all known animal ACL enzymes having a homomeric structure, plant ACLs are composed of alpha and beta chains (By similarity). {ECO:0000250}.
Similarity Belongs to the succinate/malate CoA ligase beta subunit family. {ECO:0000305}.
Subcellular Location Cytoplasm, cytosol {ECO:0000250}.
Subunit Heterooctamer of 4 alpha and 4 beta chains. {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP009879 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
15219818 RefSeq NP_176280 423 ATP-citrate lyase A-2

Identical Sequences to LMP009879 proteins

Reference Database Accession Length Protein Name
GI:15219818 GenBank AAB71965.1 423 Similar to ATP-citrate-lyase [Arabidopsis thaliana]
GI:15219818 GenBank ABN27999.1 423 Sequence 396 from patent US 7157621
GI:15219818 GenBank AEE33735.1 423 ATP-citrate lyase A-2 [Arabidopsis thaliana]
GI:15219818 SwissProt O22718.1 423 RecName: Full=ATP-citrate synthase alpha chain protein 2; Short=ATP-citrate synthase A-2; AltName: Full=ATP-citrate lyase A-2; AltName: Full=Citrate cleavage enzyme A-2 [Arabidopsis thaliana]

Related Sequences to LMP009879 proteins

Reference Database Accession Length Protein Name
GI:15219818 GenBank AAL91162.1 423 similar to ATP-citrate-lyase [Arabidopsis thaliana]
GI:15219818 GenBank AAM91141.1 423 similar to ATP-citrate-lyase [Arabidopsis thaliana]
GI:15219818 GenBank EFH62844.1 423 ATP-citrate lyase A-2 [Arabidopsis lyrata subsp. lyrata]
GI:15219818 RefSeq XP_002886585.1 423 ATP-citrate lyase A-2 [Arabidopsis lyrata subsp. lyrata]
GI:15219818 RefSeq XP_010510905.1 423 PREDICTED: ATP-citrate synthase alpha chain protein 2-like [Camelina sativa]
GI:15219818 RefSeq XP_010418026.1 423 PREDICTED: ATP-citrate synthase alpha chain protein 2 [Camelina sativa]