Gene/Proteome Database (LMPD)

LMPD ID
LMP009882
Gene ID
835006
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
ATP citrate lyase subunit B 2
Gene Symbol
ACLB-2
Synonyms
ATP citrate lyase subunit B 2; K7J8.14; K7J8_14
Alternate Names
ATP citrate lyase subunit B 2
Chromosome
5
EC Number
2.3.3.8

Proteins

ATP citrate lyase subunit B 2
Refseq ID NP_199757
Protein GI 15239897
UniProt ID Q9FGX1
mRNA ID NM_124323
Length 608
RefSeq Status REVIEWED
MATGQLFSRTTQALFYNYKQLPVQRMLDFDFLCGRETPSVAGIINPGSEGFQKLFFGQEEIAIPVHAAIEAACAAHPTADVFINFASFRSAAASSMAALKQPTIKVVAIIAEGVPESDTKQLIAYARANNKVVIGPATVGGIQAGAFKIGDTAGTIDNIIQCKLYRPGSVGFVSKSGGMSNEMYNTVARVTDGIYEGIAIGGDVFPGSTLSDHILRFNNIPQIKMMVVLGELGGRDEYSLVEALKEGKVNKPVVAWVSGTCARLFKSEVQFGHAGAKSGGEMESAQAKNQALIDAGAIVPTSFEALESAIKETFEKLVEEGKVSPIKEVIPPQIPEDLNSAIKSGKVRAPTHIISTISDDRGEEPCYAGVPMSSIIEQGYGVGDVISLLWFKRSLPRYCTKFIEICIMLCADHGPCVSGAHNTIVTARAGKDLVSSLVSGLLTIGPRFGGAIDDAARYFKDACDRNLTPYEFVEGMKKKGIRVPGIGHRIKSRDNRDKRVELLQKFARSNFPSVKYMEYAVTVETYTLSKANNLVLNVDGAIGSLFLDLLAGSGMFTKQEIDEIVQIGYLNGLFVLARSIGLIGHTFDQKRLKQPLYRHPWEDVLYTK

Gene Information

Entrez Gene ID
835006
Gene Name
ATP citrate lyase subunit B 2
Gene Symbol
ACLB-2
Species
Arabidopsis thaliana

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0009346 IDA:TAIR C citrate lyase complex
GO:0005829 IDA:TAIR C cytosol
GO:0005886 IDA:TAIR C plasma membrane
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0003878 IDA:TAIR F ATP citrate synthase activity
GO:0046872 IEA:UniProtKB-KW F metal ion binding
GO:0004775 IEA:InterPro F succinate-CoA ligase (ADP-forming) activity
GO:0006085 TAS:TAIR P acetyl-CoA biosynthetic process
GO:0044262 IEA:InterPro P cellular carbohydrate metabolic process
GO:0006629 IEA:UniProtKB-KW P lipid metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
ath01110 Biosynthesis of secondary metabolites
ath00020 Citrate cycle (TCA cycle)
ko00020 Citrate cycle (TCA cycle)
ath01100 Metabolic pathways

Domain Information

InterPro Annotations

Accession Description
IPR005811 ATP-citrate lyase/succinyl-CoA ligase
IPR017440 ATP-citrate lyase/succinyl-CoA ligase, active site
IPR002020 Citrate synthase-like
IPR016141 Citrate synthase-like, core
IPR016142 Citrate synthase-like, large alpha subdomain
IPR016143 Citrate synthase-like, small alpha subdomain
IPR016040 NAD(P)-binding domain
IPR005810 Succinyl-CoA ligase, alpha subunit
IPR017866 Succinyl-CoA synthetase, beta subunit, conserved site
IPR016102 Succinyl-CoA synthetase-like

UniProt Annotations

Entry Information

Gene Name
ATP citrate lyase subunit B 2
Protein Entry
ACLB2_ARATH
UniProt ID
Q9FGX1
Species
Arabidopsis

Comments

Comment Type Description
Catalytic Activity ADP + phosphate + acetyl-CoA + oxaloacetate = ATP + citrate + CoA.
Developmental Stage Expressed in flower buds at stage 6 of development in tapetal cells and at stage 10 in the epidermal cells of growing petals and ovaries. In young siliques, expressed transiently in the inner integument of the ovules just prior to testal deposition. Expressed in the developing embryo with a maximal level at the heart and torpedo stages. The expression then disappears in the mature embryo. During seed germination, expressed in the vascular bundles, apical meristem, epidermis of the seedling cotyledon, stem, and root. Highly expressed in the root tip of seedlings 4 days after imbibition. {ECO:0000269|PubMed:12376641}.
Function ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA, used for the elongation of fatty acids and biosynthesis of isoprenoids, flavonoids and malonated derivatives. May supply substrate to the cytosolic acetyl-CoA carboxylase, which generates the malonyl-CoA used for the synthesis of a multitude of compounds, including very long chain fatty acids and flavonoids. Required for normal growth and development and elongation of C18 fatty acids to C20 to C24 fatty acids in seeds. n contrast to all known animal ACL enzymes having a homomeric structure, plant ACLs are composed of alpha and beta chains. {ECO:0000269|PubMed:12376641}.
Similarity Belongs to the succinate/malate CoA ligase alpha subunit family. {ECO:0000305}.
Subcellular Location Cytoplasm, cytosol {ECO:0000269|PubMed:12376641}.
Subunit Heterooctamer of 4 alpha and 4 beta chains. {ECO:0000305|PubMed:12376641}.
Tissue Specificity Expressed in trichomes, epidermal leaf cells, anther tapetal cells, stigma and in young vascular bundles of expanding leaves, cotyledons, roots, pedicel of flowers and siliques. {ECO:0000269|PubMed:12376641}.

Identical and Related Proteins

Unique RefSeq proteins for LMP009882 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
15239897 RefSeq NP_199757 608 ATP citrate lyase subunit B 2

Identical Sequences to LMP009882 proteins

Reference Database Accession Length Protein Name
GI:15239897 GenBank AAV24565.1 608 Sequence 12 from patent US 6764851
GI:15239897 GenBank ABA65423.1 608 Sequence 12 from patent US 6942994
GI:15239897 GenBank ABN27998.1 608 Sequence 395 from patent US 7157621
GI:15239897 GenBank ACR90693.1 608 Sequence 12 from patent US 7524678
GI:15239897 gnl TAIR 608 ATP citrate lyase subunit B 2 [Arabidopsis thaliana]
GI:15239897 SwissProt Q9FGX1.1 608 RecName: Full=ATP-citrate synthase beta chain protein 2; Short=ATP-citrate synthase B-2; AltName: Full=ATP-citrate lyase B-2; AltName: Full=Citrate cleavage enzyme B-2 [Arabidopsis thaliana]

Related Sequences to LMP009882 proteins

Reference Database Accession Length Protein Name
GI:15239897 GenBank EFH40243.1 608 ATP-citrate lyase B-2 [Arabidopsis lyrata subsp. lyrata]
GI:15239897 GenBank EOA12770.1 608 hypothetical protein CARUB_v10028626mg [Capsella rubella]
GI:15239897 RefSeq XP_002863984.1 608 ATP-citrate lyase B-2 [Arabidopsis lyrata subsp. lyrata]
GI:15239897 RefSeq XP_006279872.1 608 hypothetical protein CARUB_v10028626mg [Capsella rubella]
GI:15239897 RefSeq XP_010440596.1 608 PREDICTED: ATP-citrate synthase beta chain protein 2-like [Camelina sativa]
GI:15239897 RefSeq XP_010442412.1 608 PREDICTED: ATP-citrate synthase beta chain protein 2 [Camelina sativa]