Gene/Proteome Database (LMPD)
LMPD ID
LMP010066
Gene ID
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
cytochrome P450, family 703, subfamily A, polypeptide 2
Gene Symbol
Synonyms
CYP703; CYP703A2; cytochrome P450; F6F3.8; F6F3_8; family 703; polypeptide 2; subfamily A
Alternate Names
cytochrome P450, family 703, subfamily A, polypeptide 2
Chromosome
1
EC Number
1.14.-.-
Summary
member of CYP703A CYP703A2 is expressed specifically in anthers of land plants, catalyzing the in-chain hydroxylation at the C-7 position of medium-chain saturated fatty acids (lauric acid in-chain hydroxylase) which is involved in pollen development (sporopollenin synthesis).
Orthologs
Proteins
| cytochrome P450, family 703, subfamily A, polypeptide 2 | |
|---|---|
| Refseq ID | NP_171635 |
| Protein GI | 15223365 |
| UniProt ID | Q9LNJ4 |
| mRNA ID | NM_100010 |
| Length | 510 |
| RefSeq Status | REVIEWED |
| MILVLASLFAVLILNVLLWRWLKASACKAQRLPPGPPRLPILGNLLQLGPLPHRDLASLCDKYGPLVYLRLGNVDAITTNDPDTIREILLRQDDVFSSRPKTLAAVHLAYGCGDVALAPMGPHWKRMRRICMEHLLTTKRLESFTTQRAEEARYLIRDVFKRSETGKPINLKEVLGAFSMNNVTRMLLGKQFFGPGSLVSPKEAQEFLHITHKLFWLLGVIYLGDYLPFWRWVDPSGCEKEMRDVEKRVDEFHTKIIDEHRRAKLEDEDKNGDMDFVDVLLSLPGENGKAHMEDVEIKALIQDMIAAATDTSAVTNEWAMAEAIKQPRVMRKIQEELDNVVGSNRMVDESDLVHLNYLRCVVRETFRMHPAGPFLIPHESVRATTINGYYIPAKTRVFINTHGLGRNTKIWDDVEDFRPERHWPVEGSGRVEISHGPDFKILPFSAGKRKCPGAPLGVTMVLMALARLFHCFEWSSPGNIDTVEVYGMTMPKAKPLRAIAKPRLAAHLYT | |
Gene Information
Entrez Gene ID
Gene Name
cytochrome P450, family 703, subfamily A, polypeptide 2
Gene Symbol
Species
Arabidopsis thaliana
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0016021 | IEA:UniProtKB-KW | C | integral component of membrane |
| GO:0020037 | IEA:InterPro | F | heme binding |
| GO:0005506 | IEA:InterPro | F | iron ion binding |
| GO:0016709 | IDA:TAIR | F | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen |
| GO:0051792 | IDA:TAIR | P | medium-chain fatty acid biosynthetic process |
| GO:0051791 | IDA:TAIR | P | medium-chain fatty acid metabolic process |
| GO:0010584 | IMP:TAIR | P | pollen exine formation |
| GO:0010208 | IMP:TAIR | P | pollen wall assembly |
| GO:0080110 | IMP:TAIR | P | sporopollenin biosynthetic process |
BIOCYC Pathway Links
Domain Information
UniProt Annotations
Entry Information
Gene Name
cytochrome P450, family 703, subfamily A, polypeptide 2
Protein Entry
C70A2_ARATH
UniProt ID
Species
Arabidopsis
Comments
| Comment Type | Description |
|---|---|
| Cofactor | Name=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250}; |
| Developmental Stage | Specifically expressed in the tapetum cell layer and the microspores of anthers at the tetrad stage. Expression starts to decrease during pollen maturation and tapetum cell degeneration to finally disappear. {ECO:0000269|PubMed:17496121}. |
| Disruption Phenotype | Impaired pollen development and partial male-sterile phenotype. {ECO:0000269|PubMed:17496121}. |
| Function | Involved in pollen wall development. Catalyzes the conversion of medium-chain saturated fatty acids to the corresponding monohydroxylated fatty acids, with a preferential hydroxylation of lauric acid at the C-7 position. In-chain hydroxylated fatty acids, together with omega-hydroxylated fatty acids, are key monomeric aliphatic building blocks for sporopollenin synthesis during exine formation. {ECO:0000269|PubMed:17496121}. |
| Similarity | Belongs to the cytochrome P450 family. {ECO:0000305}. |
| Subcellular Location | Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP010066 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 15223365 | RefSeq | NP_171635 | 510 | cytochrome P450, family 703, subfamily A, polypeptide 2 |
Identical Sequences to LMP010066 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:15223365 | GenBank | AAF97323.1 | 510 | Putative cytochrome P450 [Arabidopsis thaliana] |
| GI:15223365 | GenBank | AAY25435.1 | 510 | At1g01280 [Arabidopsis thaliana] |
| GI:15223365 | GenBank | ACX20389.1 | 510 | Sequence 48901 from patent US 7569389 |
| GI:15223365 | GenBank | AEE27265.1 | 510 | cytochrome P450, family 703, subfamily A, polypeptide 2 [Arabidopsis thaliana] |
| GI:15223365 | GenBank | AEL86880.1 | 510 | Sequence 3745 from patent US 7989676 |
| GI:15223365 | SwissProt | Q9LNJ4.1 | 510 | RecName: Full=Cytochrome P450 703A2 [Arabidopsis thaliana] |
Related Sequences to LMP010066 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:15223365 | GenBank | EOA38917.1 | 510 | hypothetical protein CARUB_v10011315mg [Capsella rubella] |
| GI:15223365 | RefSeq | XP_006306019.1 | 510 | hypothetical protein CARUB_v10011315mg [Capsella rubella] |
| GI:15223365 | RefSeq | XP_006418407.1 | 510 | hypothetical protein EUTSA_v10007395mg [Eutrema salsugineum] |
| GI:15223365 | RefSeq | XP_010501277.1 | 510 | PREDICTED: cytochrome P450 703A2 [Camelina sativa] |
| GI:15223365 | RefSeq | XP_010457143.1 | 510 | PREDICTED: cytochrome P450 703A2-like [Camelina sativa] |
| GI:15223365 | RefSeq | XP_010474719.1 | 510 | PREDICTED: cytochrome P450 703A2-like [Camelina sativa] |