Gene/Proteome Database (LMPD)
LMPD ID
LMP010084
Gene ID
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
cytochrome P450, family 86, subfamily A, polypeptide 8
Gene Symbol
Synonyms
cytochrome P450; F4I18.5; family 86; LACERATA; LCR; polypeptide 8; subfamily A
Alternate Names
cytochrome P450, family 86, subfamily A, polypeptide 8
Chromosome
2
EC Number
1.14.14.1
Summary
Encodes a member of the CYP86A subfamily of cytochrome p450 genes. Expressed at moderate levels in flowers, leaves, roots and stems.
Orthologs
Proteins
| cytochrome P450, family 86, subfamily A, polypeptide 8 | |
|---|---|
| Refseq ID | NP_182121 |
| Protein GI | 15225914 |
| UniProt ID | O80823 |
| mRNA ID | NM_130160 |
| Length | 537 |
| RefSeq Status | REVIEWED |
| MEISTALMILSAITAYFLWLTFISRCLKGPRVWPILGSLPGLIENCERMHDWISDNLRACSGTYQTCICAIPFLAKKQGLVTVTCDPRNLEHILKNRFDNYPKGPTWQAVFHDLLGQGIFNSDGDTWLFQRKTAALEFTTRTLRQAMARWVNRAIKLRFLPILENARLGSEPIDLQDLLLRLTFDNICGLTFGKDPRTCAPGLPVNTFAVAFDRATEASLQRFILPEILWKFKRWLRLGLEVSLTRSLVQVDNYLSEIITTRKEEMMTQHNNGKHHDDLLSRFIKKKESYSDETLQRVALNFILAGRDTSSVALSWFFWLITQHPAIEDKILREICTVLVETRGDDVALWTDEPLSCEELDRLVFLKAALSETLRLYPSVPEDSKRAVKDDVLPDGTFVPAGSSITYSIYSAGRMKSTWGEDCLEFKPERWISQSDGGRFINHDPFKFVAFNAGPRICLGKDLAYLQMKSIASAVLLRHRLTVVTGHKVEQKMSLTLFMKYGLLVNVHERDLTAIAADLRECKSNVVNDGVGNGVSS | |
Gene Information
Entrez Gene ID
Gene Name
cytochrome P450, family 86, subfamily A, polypeptide 8
Gene Symbol
Species
Arabidopsis thaliana
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0016021 | IEA:UniProtKB-KW | C | integral component of membrane |
| GO:0018685 | IDA:TAIR | F | alkane 1-monooxygenase activity |
| GO:0070330 | IEA:UniProtKB-EC | F | aromatase activity |
| GO:0020037 | IEA:InterPro | F | heme binding |
| GO:0005506 | IEA:InterPro | F | iron ion binding |
| GO:0006631 | IDA:TAIR | P | fatty acid metabolic process |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| ath00073 | Cutin, suberine and wax biosynthesis |
| ko00073 | Cutin, suberine and wax biosynthesis |
| ath01100 | Metabolic pathways |
BIOCYC Pathway Links
| BIOCYC Pathway ID | Description |
|---|---|
| PWY-321 | cutin biosynthesis |
Domain Information
UniProt Annotations
Entry Information
Gene Name
cytochrome P450, family 86, subfamily A, polypeptide 8
Protein Entry
C86A8_ARATH
UniProt ID
Species
Arabidopsis
Comments
| Comment Type | Description |
|---|---|
| Catalytic Activity | RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O. |
| Cofactor | Name=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250}; |
| Disruption Phenotype | Organ fusion between rosette leaves and in inflorescences. {ECO:0000269|PubMed:11493698}. |
| Function | Catalyzes the omega-hydroxylation of various fatty acids (FA). Acts on saturated and unsaturated fatty acids with chain lengths from C12 to C18. May be involved in the biosynthesis of cutin in the epidermis which prevents post-genital organ fusions. Hydroxylated FAs may be important for trichome differentiation, establishment of apical dominance and senescence. {ECO:0000269|PubMed:11493698, ECO:0000269|PubMed:15709153, ECO:0000269|PubMed:17427946}. |
| Induction | Induced by abscisic acid (ABA) and auxin. Down- regulated by wounding. {ECO:0000269|PubMed:15709153}. |
| Similarity | Belongs to the cytochrome P450 family. {ECO:0000305}. |
| Subcellular Location | Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. |
| Tissue Specificity | Expressed in leaves, stems, flowers and siliques. Expressed at low levels in roots. {ECO:0000269|PubMed:15709153}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP010084 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 15225914 | RefSeq | NP_182121 | 537 | cytochrome P450, family 86, subfamily A, polypeptide 8 |
Identical Sequences to LMP010084 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:15225914 | EMBL | CBD07666.1 | 537 | unnamed protein product [Arabidopsis thaliana] |
| GI:15225914 | EMBL | CBD09680.1 | 537 | unnamed protein product [Arabidopsis thaliana] |
| GI:15225914 | EMBL | CBD14338.1 | 537 | unnamed protein product [Arabidopsis thaliana] |
| GI:15225914 | EMBL | CBD10340.1 | 537 | unnamed protein product [Arabidopsis thaliana] |
| GI:15225914 | EMBL | CBC98105.1 | 537 | unnamed protein product [Arabidopsis thaliana] |
| GI:15225914 | GenBank | AEC10625.1 | 537 | cytochrome P450, family 86, subfamily A, polypeptide 8 [Arabidopsis thaliana] |
Related Sequences to LMP010084 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:15225914 | GenBank | EFH58302.1 | 524 | CYP86A8 [Arabidopsis lyrata subsp. lyrata] |
| GI:15225914 | GenBank | EOA26875.1 | 535 | hypothetical protein CARUB_v10022968mg [Capsella rubella] |
| GI:15225914 | RefSeq | XP_002882043.1 | 524 | CYP86A8 [Arabidopsis lyrata subsp. lyrata] |
| GI:15225914 | RefSeq | XP_010506590.1 | 538 | PREDICTED: cytochrome P450 86A8-like isoform X1 [Camelina sativa] |
| GI:15225914 | RefSeq | XP_010506591.1 | 538 | PREDICTED: cytochrome P450 86A8-like isoform X2 [Camelina sativa] |
| GI:15225914 | RefSeq | XP_010508082.1 | 539 | PREDICTED: cytochrome P450 86A8 [Camelina sativa] |