Gene/Proteome Database (LMPD)

LMPD ID
LMP010144
Gene ID
820606
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
dihydrolipoamide acetyltransferase, long form protein
Gene Symbol
AT3G13930
Alternate Names
dihydrolipoamide acetyltransferase, long form protein
Chromosome
3
EC Number
2.3.1.12

Proteins

dihydrolipoamide acetyltransferase, long form protein
Refseq ID NP_566470
Protein GI 18400212
UniProt ID Q8RWN9
mRNA ID NM_112247
Length 539
RefSeq Status REVIEWED
MASRIINHSKKLKHVSALLRRDHAVAVRCFSNSTHPSLVGREDIFKARLNYSSVERISKCGTGNVTMLSGISTTSTKLSSPMAGPKLFKEFISSQMRSVRGFSSSSDLPPHQEIGMPSLSPTMTEGNIARWLKKEGDKVAPGEVLCEVETDKATVEMECMEEGFLAKIVKEEGAKEIQVGEVIAITVEDEDDIQKFKDYTPSSDTGPAAPEAKPAPSLPKEEKVEKPASAPEAKISKPSSAPSEDRIFASPLARKLAEDNNVPLSSIKGTGPEGRIVKADVEDFLASGSKETTAKPSKQVDSKVPALDYVDIPHTQIRKVTASRLAFSKQTIPHYYLTVDTCVDKMMGLRSQLNSFQEASGGKRISVNDLVIKAAALALRKVPQCNSSWTDEYIRQFKNVNINVAVQTENGLYVPVVKDADKKGLSTIGEEVRFLAQKAKENSLKPEDYEGGTFTVSNLGGPFGIKQFCAVINPPQAAILAIGSAEKRVVPGTGPDQYNVASYMSVTLSCDHRVIDGAIGAEWLKAFKGYIETPESMLL

Gene Information

Entrez Gene ID
820606
Gene Name
dihydrolipoamide acetyltransferase, long form protein
Gene Symbol
AT3G13930
Species
Arabidopsis thaliana

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0009507 IDA:TAIR C chloroplast
GO:0009941 IDA:TAIR C chloroplast envelope
GO:0005739 IDA:TAIR C mitochondrion
GO:0045254 IEA:InterPro C pyruvate dehydrogenase complex
GO:0005507 IDA:TAIR F copper ion binding
GO:0004742 IEA:UniProtKB-EC F dihydrolipoyllysine-residue acetyltransferase activity
GO:0006096 IEA:UniProtKB-KW P glycolytic process

KEGG Pathway Links

KEGG Pathway ID Description
ath01200 Carbon metabolism
ath00020 Citrate cycle (TCA cycle)
ath00010 Glycolysis / Gluconeogenesis
ath_M00307 Pyruvate oxidation, pyruvate => acetyl-CoA

Domain Information

InterPro Annotations

Accession Description
IPR003016 2-oxo acid dehydrogenase, lipoyl-binding site
IPR001078 2-oxoacid dehydrogenase acyltransferase, catalytic domain
IPR000089 Biotin/lipoyl attachment
IPR023213 Chloramphenicol acetyltransferase-like domain
IPR006257 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex
IPR004167 E3-binding domain
IPR011053 Single hybrid motif

UniProt Annotations

Entry Information

Gene Name
dihydrolipoamide acetyltransferase, long form protein
Protein Entry
ODP22_ARATH
UniProt ID
Q8RWN9
Species
Arabidopsis

Comments

Comment Type Description
Catalytic Activity Acetyl-CoA + enzyme N(6)-(dihydrolipoyl)lysine = CoA + enzyme N(6)-(S-acetyldihydrolipoyl)lysine.
Cofactor Name=(R)-lipoate; Xref=ChEBI:CHEBI:83088; Note=Binds 1 lipoyl cofactor covalently.;
Function The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). {ECO:0000269|PubMed:14764908}.
Sequence Caution Sequence=BAB02323.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Similarity Belongs to the 2-oxoacid dehydrogenase family. {ECO:0000305}.
Similarity Contains 1 lipoyl-binding domain. {ECO:0000255|PROSITE-ProRule:PRU01066, ECO:0000305}.
Subcellular Location Mitochondrion matrix {ECO:0000269|PubMed:14671022}.

Identical and Related Proteins

Unique RefSeq proteins for LMP010144 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
18400212 RefSeq NP_566470 539 dihydrolipoamide acetyltransferase, long form protein

Identical Sequences to LMP010144 proteins

Reference Database Accession Length Protein Name
GI:18400212 GenBank AAM10290.1 539 AT3g13930/MDC16_5 [Arabidopsis thaliana]
GI:18400212 GenBank AAN17421.1 539 putative acetyltransferase [Arabidopsis thaliana]
GI:18400212 GenBank AAN31846.1 539 putative acetyltransferase [Arabidopsis thaliana]
GI:18400212 GenBank AAN65110.1 539 putative acetyltransferase [Arabidopsis thaliana]
GI:18400212 GenBank AEE75442.1 539 dihydrolipoamide acetyltransferase, long form protein [Arabidopsis thaliana]
GI:18400212 SwissProt Q8RWN9.2 539 RecName: Full=Dihydrolipoyllysine-residue acetyltransferase component 2 of pyruvate dehydrogenase complex, mitochondrial; AltName: Full=Dihydrolipoamide S-acetyltransferase component 2 of pyruvate dehydrogenase complex; AltName: Full=Pyruvate dehydrogenase complex component E2 2; Short=PDC-E2 2; Short=PDCE2 2; Flags: Precursor [Arabidopsis thaliana]

Related Sequences to LMP010144 proteins

Reference Database Accession Length Protein Name
GI:18400212 DBBJ BAB02323.1 546 dihydrolipoamide acetyltransferase [Arabidopsis thaliana]
GI:18400212 GenBank AAM12967.1 539 dihydrolipoamide acetyltransferase [Arabidopsis thaliana]
GI:18400212 GenBank EFH59119.1 539 hypothetical protein ARALYDRAFT_478800 [Arabidopsis lyrata subsp. lyrata]
GI:18400212 GenBank EOA32882.1 541 hypothetical protein CARUB_v10016198mg [Capsella rubella]
GI:18400212 RefSeq XP_002882860.1 539 hypothetical protein ARALYDRAFT_478800 [Arabidopsis lyrata subsp. lyrata]
GI:18400212 RefSeq XP_006299984.1 541 hypothetical protein CARUB_v10016198mg [Capsella rubella]