Gene/Proteome Database (LMPD)

LMPD ID
LMP010145
Gene ID
841863
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
dihydrolipoyllysine-residue acetyltransferase component 3 of pyruvate dehydrogenase complex
Gene Symbol
AT1G54220
Synonyms
F20D21.4; F20D21_4
Alternate Names
dihydrolipoyllysine-residue acetyltransferase component 3 of pyruvate dehydrogenase complex
Chromosome
1
EC Number
2.3.1.12

Proteins

dihydrolipoyllysine-residue acetyltransferase component 3 of pyruvate dehydrogenase complex
Refseq ID NP_001031186
Protein GI 79319911
UniProt ID Q5M729
mRNA ID NM_001036109
Length 539
RefSeq Status REVIEWED
MAYASRIINHSKKLKDVSTLLRRENAATIRYYSNTNRAPLNREDTFNSRLGYPPLERISICSTSTLPVSIIFSTTRSNLSSAMGRPIFGKEFSCLMQSARGFSSGSDLPPHQEIGMPSLSPTMTEGNIARWLKKEGDKVAPGEVLCEVETDKATVEMECMEEGYLAKIVKAEGSKEIQVGEVIAITVEDEEDIGKFKDYTPSSTADAAPTKAEPTPAPPKEEKVKQPSSPPEPKASKPSTPPTGDRVFASPLARKLAEDNNVPLSDIEGTGPEGRIVKADIDEYLASSGKGATAKPSKSTDSKAPALDYVDIPHSQIRKVTASRLAFSKQTIPHYYLTVDTCVDKLMALRSQLNSFKEASGGKRISVNDLVVKAAALALRKVPQCNSSWTDDYIRQFKNVNINVAVQTENGLYVPVVKDADRKGLSTIGEEVRLLAQKAKENSLKPEDYEGGTFTVSNLGGPFGIKQFCAVVNPPQAAILAVGSAEKRVVPGNGPDQFNFASYMPVTLSCDHRVVDGAIGAEWLKAFKGYIENPKSMLL
dihydrolipoyllysine-residue acetyltransferase component 3 of pyruvate dehydrogenase complex
Refseq ID NP_564654
Protein GI 18404837
UniProt ID Q5M729
mRNA ID NM_104300
Length 539
RefSeq Status REVIEWED
Protein sequence is identical to GI:79319911 (mRNA isoform)

Gene Information

Entrez Gene ID
841863
Gene Name
dihydrolipoyllysine-residue acetyltransferase component 3 of pyruvate dehydrogenase complex
Gene Symbol
AT1G54220
Species
Arabidopsis thaliana

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005739 IDA:TAIR C mitochondrion
GO:0045254 IEA:InterPro C pyruvate dehydrogenase complex
GO:0004742 IEA:UniProtKB-EC F dihydrolipoyllysine-residue acetyltransferase activity
GO:0006096 IEA:UniProtKB-KW P glycolytic process

KEGG Pathway Links

KEGG Pathway ID Description
ath01200 Carbon metabolism
ath00020 Citrate cycle (TCA cycle)
ath00010 Glycolysis / Gluconeogenesis
ath_M00307 Pyruvate oxidation, pyruvate => acetyl-CoA

Domain Information

InterPro Annotations

Accession Description
IPR003016 2-oxo acid dehydrogenase, lipoyl-binding site
IPR001078 2-oxoacid dehydrogenase acyltransferase, catalytic domain
IPR000089 Biotin/lipoyl attachment
IPR023213 Chloramphenicol acetyltransferase-like domain
IPR006257 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex
IPR004167 E3-binding domain
IPR011053 Single hybrid motif

UniProt Annotations

Entry Information

Gene Name
dihydrolipoyllysine-residue acetyltransferase component 3 of pyruvate dehydrogenase complex
Protein Entry
ODP23_ARATH
UniProt ID
Q5M729
Species
Arabidopsis

Comments

Comment Type Description
Catalytic Activity Acetyl-CoA + enzyme N(6)-(dihydrolipoyl)lysine = CoA + enzyme N(6)-(S-acetyldihydrolipoyl)lysine.
Cofactor Name=(R)-lipoate; Xref=ChEBI:CHEBI:83088; Note=Binds 1 lipoyl cofactor covalently.;
Function The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). {ECO:0000269|PubMed:14764908}.
Sequence Caution Sequence=AAD25602.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Similarity Belongs to the 2-oxoacid dehydrogenase family. {ECO:0000305}.
Similarity Contains 1 lipoyl-binding domain. {ECO:0000255|PROSITE-ProRule:PRU01066, ECO:0000305}.
Subcellular Location Mitochondrion matrix {ECO:0000269|PubMed:14671022}.

Identical and Related Proteins

Unique RefSeq proteins for LMP010145 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
79319911 RefSeq NP_001031186 539 dihydrolipoyllysine-residue acetyltransferase component 3 of pyruvate dehydrogenase complex

Identical Sequences to LMP010145 proteins

Reference Database Accession Length Protein Name
GI:79319911 GenBank AAV97810.1 539 At1g54220 [Arabidopsis thaliana]
GI:79319911 GenBank AEE33067.1 539 dihydrolipoyllysine-residue acetyltransferase component 3 of pyruvate dehydrogenase complex [Arabidopsis thaliana]
GI:79319911 GenBank AEE33068.1 539 dihydrolipoyllysine-residue acetyltransferase component 3 of pyruvate dehydrogenase complex [Arabidopsis thaliana]
GI:79319911 RefSeq NP_564654.1 539 dihydrolipoyllysine-residue acetyltransferase component 3 of pyruvate dehydrogenase complex [Arabidopsis thaliana]
GI:79319911 SwissProt Q5M729.1 539 RecName: Full=Dihydrolipoyllysine-residue acetyltransferase component 3 of pyruvate dehydrogenase complex, mitochondrial; AltName: Full=Dihydrolipoamide S-acetyltransferase component 3 of pyruvate dehydrogenase complex; AltName: Full=Pyruvate dehydrogenase complex component E2 3; Short=PDC-E2 3; Short=PDCE2 3; Flags: Precursor [Arabidopsis thaliana]

Related Sequences to LMP010145 proteins

Reference Database Accession Length Protein Name
GI:79319911 GenBank AAK53067.1 539 mono-lipoyl E2 [Arabidopsis thaliana]
GI:79319911 GenBank AAM97076.1 539 dihydrolipoamide S-acetyltransferase, putative [Arabidopsis thaliana]
GI:79319911 GenBank EOA37629.1 544 hypothetical protein CARUB_v10012071mg [Capsella rubella]
GI:79319911 RefSeq XP_006304731.1 544 hypothetical protein CARUB_v10012071mg [Capsella rubella]
GI:79319911 RefSeq XP_010501097.1 539 PREDICTED: dihydrolipoyllysine-residue acetyltransferase component 3 of pyruvate dehydrogenase complex, mitochondrial [Camelina sativa]
GI:79319911 RefSeq XP_010462335.1 539 PREDICTED: dihydrolipoyllysine-residue acetyltransferase component 3 of pyruvate dehydrogenase complex, mitochondrial-like [Camelina sativa]