Gene/Proteome Database (LMPD)
LMPD ID
LMP010189
Gene ID
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
ethanolamine-phosphate cytidylyltransferase
Gene Symbol
Synonyms
phosphorylethanolamine cytidylyltransferase 1; T6A23.13; T6A23_13
Alternate Names
ethanolamine-phosphate cytidylyltransferase
Chromosome
2
EC Number
2.7.7.14
Summary
Encodes a mitochondrial ethanolamine-phosphate cytidylyltransferase, involved in phosphatidylethanolamine (PE) biosynthesis.
Orthologs
Proteins
| ethanolamine-phosphate cytidylyltransferase | |
|---|---|
| Refseq ID | NP_181401 |
| Protein GI | 15224925 |
| UniProt ID | Q9ZVI9 |
| mRNA ID | NM_129424 |
| Length | 421 |
| RefSeq Status | REVIEWED |
| MVWEKEKIVGSCIVGGAAFAVGASFLHLFLKGELPLGLGLGLSCPWRILRKRKPVRVYMDGCFDMMHYGHCNALRQARALGDQLVVGVVSDEEIIANKGPPVTPLHERMTMVKAVKWVDEVISDAPYAITEDFMKKLFDEYQIDYIIHGDDPCVLPDGTDAYALAKKAGRYKQIKRTEGVSSTDIVGRMLLCVRERSISDTHSRSSLQRQFSHGHSSPKFEDGASSAGTRVSHFLPTSRRIVQFSNGKGPGPDARIIYIDGAFDLFHAGHVEILRRARELGDFLLVGIHNDQTVSAKRGAHRPIMNLHERSLSVLACRYVDEVIIGAPWEVSRDTITTFDISLVVHGTVAESDDFRKEEDNPYSVPISMGIFQVLDSPLDITTSTIIRRIVANHEAYQKRNAKKEASEKKYYEQKSFVSGD | |
Gene Information
Entrez Gene ID
Gene Name
ethanolamine-phosphate cytidylyltransferase
Gene Symbol
Species
Arabidopsis thaliana
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0031307 | IDA:TAIR | C | integral component of mitochondrial outer membrane |
| GO:0005739 | IDA:TAIR | C | mitochondrion |
| GO:0004306 | IMP:TAIR | F | ethanolamine-phosphate cytidylyltransferase activity |
| GO:0006646 | TAS:TAIR | P | phosphatidylethanolamine biosynthetic process |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| ath00564 | Glycerophospholipid metabolism |
| ath01100 | Metabolic pathways |
| ath_M00092 | Phosphatidylethanolamine (PE) biosynthesis, ethanolamine => PE |
REACTOME Pathway Links
| REACTOME Pathway ID | Description |
|---|---|
| 6254314 | Synthesis of PE |
Domain Information
UniProt Annotations
Entry Information
Gene Name
ethanolamine-phosphate cytidylyltransferase
Protein Entry
PECT1_ARATH
UniProt ID
Species
Arabidopsis
Comments
| Comment Type | Description |
|---|---|
| Catalytic Activity | CTP + ethanolamine phosphate = diphosphate + CDP-ethanolamine. |
| Disruption Phenotype | Embryonic lethality when homozygous. {ECO:0000269|PubMed:17189343}. |
| Function | Plays an important role in the biosynthesis of the phospholipid phosphatidylethanolamine. Catalyzes the formation of CDP-ethanolamine. Essential for early embryonic development. {ECO:0000269|PubMed:17189343}. |
| Pathway | Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 2/3. |
| Similarity | Belongs to the cytidylyltransferase family. {ECO:0000305}. |
| Subcellular Location | Mitochondrion outer membrane {ECO:0000305|PubMed:17189343, ECO:0000305|PubMed:21896887}; Single-pass membrane protein {ECO:0000305|PubMed:17189343, ECO:0000305|PubMed:21896887}. |
| Tissue Specificity | Expressed in root tip, lateral root primordia, leaves, shoot apex, stem vascular bundles, pollen and embryos. {ECO:0000269|PubMed:17189343}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP010189 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 15224925 | RefSeq | NP_181401 | 421 | ethanolamine-phosphate cytidylyltransferase |
Identical Sequences to LMP010189 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:15224925 | EMBL | CBF65897.1 | 421 | unnamed protein product [Arabidopsis thaliana] |
| GI:15224925 | EMBL | CBU90768.1 | 421 | unnamed protein product [Arabidopsis thaliana] |
| GI:15224925 | GenBank | AAM91207.1 | 421 | putative phospholipid cytidylyltransferase [Arabidopsis thaliana] |
| GI:15224925 | GenBank | AEC09568.1 | 421 | ethanolamine-phosphate cytidylyltransferase [Arabidopsis thaliana] |
| GI:15224925 | GenBank | AGX57860.1 | 421 | Sequence 16021 from patent US 8541208 |
| GI:15224925 | SwissProt | Q9ZVI9.1 | 421 | RecName: Full=Ethanolamine-phosphate cytidylyltransferase; AltName: Full=CTP:phosphoethanolamine cytidylyltransferase; AltName: Full=Phosphorylethanolamine cytidylyltransferase 1 [Arabidopsis thaliana] |
Related Sequences to LMP010189 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:15224925 | GenBank | EFH56018.1 | 421 | hypothetical protein ARALYDRAFT_903103 [Arabidopsis lyrata subsp. lyrata] |
| GI:15224925 | GenBank | EOA26372.1 | 420 | hypothetical protein CARUB_v10023288mg [Capsella rubella] |
| GI:15224925 | RefSeq | XP_002879759.1 | 421 | hypothetical protein ARALYDRAFT_903103 [Arabidopsis lyrata subsp. lyrata] |
| GI:15224925 | RefSeq | XP_006293474.1 | 420 | hypothetical protein CARUB_v10023288mg [Capsella rubella] |
| GI:15224925 | RefSeq | XP_010509160.1 | 420 | PREDICTED: ethanolamine-phosphate cytidylyltransferase [Camelina sativa] |
| GI:15224925 | RefSeq | XP_010517175.1 | 420 | PREDICTED: ethanolamine-phosphate cytidylyltransferase-like [Camelina sativa] |