Gene/Proteome Database (LMPD)

LMPD ID
LMP010206
Gene ID
834828
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
farnesyl diphosphate synthase 1
Gene Symbol
FPS1
Synonyms
farnesyl diphosphate synthase 1; FARNESYL DIPHOSPHATE SYNTHASE 1; FPS1; MCA23.9; MCA23_9
Alternate Names
farnesyl diphosphate synthase 1
Chromosome
5
EC Number
2.5.1.10

Proteins

farnesyl diphosphate synthase 1
Refseq ID NP_199588
Protein GI 15238801
UniProt ID Q09152
mRNA ID NM_124151
Length 384
RefSeq Status REVIEWED
MSVSCCCRNLGKTIKKAIPSHHLHLRSLGGSLYRRRIQSSSMETDLKSTFLNVYSVLKSDLLHDPSFEFTNESRLWVDRMLDYNVRGGKLNRGLSVVDSFKLLKQGNDLTEQEVFLSCALGWCIEWLQAYFLVLDDIMDNSVTRRGQPCWFRVPQVGMVAINDGILLRNHIHRILKKHFRDKPYYVDLVDLFNEVELQTACGQMIDLITTFEGEKDLAKYSLSIHRRIVQYKTAYYSFYLPVACALLMAGENLENHIDVKNVLVDMGIYFQVQDDYLDCFADPETLGKIGTDIEDFKCSWLVVKALERCSEEQTKILYENYGKPDPSNVAKVKDLYKELDLEGVFMEYESKSYEKLTGAIEGHQSKAIQAVLKSFLAKIYKRQK

Gene Information

Entrez Gene ID
834828
Gene Name
farnesyl diphosphate synthase 1
Gene Symbol
FPS1
Species
Arabidopsis thaliana

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005829 IDA:TAIR C cytosol
GO:0005739 IEA:UniProtKB-KW C mitochondrion
GO:0004161 IDA:TAIR F dimethylallyltranstransferase activity
GO:0004337 IDA:TAIR F geranyltranstransferase activity
GO:0046872 IEA:UniProtKB-KW F metal ion binding
GO:0006695 IEA:UniProtKB-KW P cholesterol biosynthetic process
GO:0045337 IDA:TAIR P farnesyl diphosphate biosynthetic process
GO:0033384 IEA:UniProtKB-UniPathway P geranyl diphosphate biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
ath01110 Biosynthesis of secondary metabolites
ath00900 Terpenoid backbone biosynthesis

REACTOME Pathway Links

REACTOME Pathway ID Description
6254329 Activation of gene expression by SREBF (SREBP)
6254036 Cholesterol biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR008949 Isoprenoid synthase domain
IPR000092 Polyprenyl synthetase

UniProt Annotations

Entry Information

Gene Name
farnesyl diphosphate synthase 1
Protein Entry
FPPS1_ARATH
UniProt ID
Q09152
Species
Arabidopsis

Comments

Comment Type Description
Alternative Products Event=Alternative initiation; Named isoforms=2; Name=Mitochondrial; Synonyms=FPS1L; IsoId=Q09152-1; Sequence=Displayed; Name=Cytoplasmic; Synonyms=FPS1S; IsoId=Q09152-2; Sequence=VSP_018808;
Catalytic Activity Dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate.
Catalytic Activity Geranyl diphosphate + isopentenyl diphosphate = diphosphate + (2E,6E)-farnesyl diphosphate.
Cofactor Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250}; Note=Binds 3 Mg(2+) ions per subunit. {ECO:0000250};
Function Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.
Pathway Isoprenoid biosynthesis; farnesyl diphosphate biosynthesis; farnesyl diphosphate from geranyl diphosphate and isopentenyl diphosphate: step 1/1.
Pathway Isoprenoid biosynthesis; geranyl diphosphate biosynthesis; geranyl diphosphate from dimethylallyl diphosphate and isopentenyl diphosphate: step 1/1.
Similarity Belongs to the FPP/GGPP synthase family. {ECO:0000305}.
Subcellular Location Mitochondrion. Cytoplasm.
Tissue Specificity The FPS1L mRNA accumulates preferentially in inflorescences, whereas the FPS1S mRNA is predominantly expressed in roots and inflorescences.

Identical and Related Proteins

Unique RefSeq proteins for LMP010206 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
15238801 RefSeq NP_199588 384 farnesyl diphosphate synthase 1

Identical Sequences to LMP010206 proteins

Reference Database Accession Length Protein Name
GI:15238801 EMBL CAW75694.1 384 unnamed protein product [Arabidopsis thaliana]
GI:15238801 EMBL CBD30825.1 384 unnamed protein product [Arabidopsis thaliana]
GI:15238801 EMBL CBC69838.1 384 unnamed protein product [Arabidopsis thaliana]
GI:15238801 EMBL CBD35247.1 384 unnamed protein product [Arabidopsis thaliana]
GI:15238801 GenBank ADT60529.1 384 Sequence 1948 from patent US 7847156
GI:15238801 gnl TAIR 384 farnesyl diphosphate synthase 1 [Arabidopsis thaliana]

Related Sequences to LMP010206 proteins

Reference Database Accession Length Protein Name
GI:15238801 EMBL CAA53433.1 343 dimethylallyltransferase [Arabidopsis thaliana]
GI:15238801 GenBank AAB07264.1 343 farnesyl diphosphate synthase short form [Arabidopsis thaliana]
GI:15238801 GenBank EOA14425.1 383 hypothetical protein CARUB_v10027627mg [Capsella rubella]
GI:15238801 RefSeq XP_006281527.1 383 hypothetical protein CARUB_v10027627mg [Capsella rubella]
GI:15238801 RefSeq XP_010481370.1 388 PREDICTED: farnesyl pyrophosphate synthase 1, mitochondrial [Camelina sativa]
GI:15238801 RefSeq XP_010494928.1 388 PREDICTED: farnesyl pyrophosphate synthase 2-like [Camelina sativa]