Gene/Proteome Database (LMPD)

LMPD ID
LMP010209
Gene ID
836512
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
farnesylcysteine lyase
Gene Symbol
FCLY
Synonyms
farnesylcysteine lyase; FCLY; MGI19.4; MGI19_4
Alternate Names
farnesylcysteine lyase
Chromosome
5
EC Number
1.8.3.6

Proteins

farnesylcysteine lyase
Refseq ID NP_201196
Protein GI 15237560
UniProt ID P57681
mRNA ID NM_125787
Length 500
RefSeq Status REVIEWED
MKDFPIAISLLFALLSPVLLPCSGDSTGGVEDDSPATVCIVGSGIGGSSVAHFLRNYSVSTGLNQAKILMFERHEIVGGRMRTVTVAGDTFEAGGSILHPKNYHVKDFVERFNLTVRLPTPIEESSAIGIWDGKRFVVKTFGSGTKFPFLDTIVSWVNDLYLFLRYGLSLLRMSSFIENTVDNFLKYYESLESRPIFDNVEGMLKWSGLYNLTKLTLQEKLSEAQLSPLLVNELVTVITRINYGQSVLISGLAGAVSLAGSGGGLWSVEGGNWQMAAKLINHSDVTLHLNEKIESISYLENHYELKSTKGNSYKCDVTVVATPLDEVDIQFSPTISIPKRELQHTHTTFVRGLLNPGYFGMKSLSDVPALVGTLEDPLIPFSCISILRKYSKTDMTYKIFTRQPASDSLLDELFSRRTETVRIDWGAYPKYHAPEVFAPFILDDHHLYYVNAFENAASTMETSAVAGENIARLIISRFMTKESLSSSDKRSCSSGLHSDS

Gene Information

Entrez Gene ID
836512
Gene Name
farnesylcysteine lyase
Gene Symbol
FCLY
Species
Arabidopsis thaliana

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005764 IEA:UniProtKB-KW C lysosome
GO:0005774 IDA:TAIR C vacuolar membrane
GO:0005773 IDA:TAIR C vacuole
GO:0001735 IDA:TAIR F prenylcysteine oxidase activity
GO:0009738 IMP:TAIR P abscisic acid-activated signaling pathway
GO:0045338 IDA:TAIR P farnesyl diphosphate metabolic process
GO:0030327 IDA:TAIR P prenylated protein catabolic process
GO:0030328 IEA:InterPro P prenylcysteine catabolic process

KEGG Pathway Links

KEGG Pathway ID Description
ath00900 Terpenoid backbone biosynthesis
ko00900 Terpenoid backbone biosynthesis

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY-6577 farnesylcysteine salvage pathway
PWY-6577 farnesylcysteine salvage pathway

Domain Information

InterPro Annotations

Accession Description
IPR010795 Prenylcysteine lyase
IPR017046 Prenylcysteine oxidase

UniProt Annotations

Entry Information

Gene Name
farnesylcysteine lyase
Protein Entry
PCYOX_ARATH
UniProt ID
P57681
Species
Arabidopsis

Comments

Comment Type Description
Catalytic Activity S-(2E,6E)-farnesyl-L-cysteine + O(2) + H(2)O = (2E,6E)-farnesal + L-cysteine + H(2)O(2). {ECO:0000269|PubMed:17425716}.
Cofactor Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000250};
Function Involved in the degradation of prenylcysteine. Cleaves specifically the thioether bond of S-farnesyl-L-cysteine and has no activity with S-geranylgeranyl-L-cysteine. Recognizes also N- acetyl-farnesylcysteine and may have a role in deprenylation of farnesylated proteins. {ECO:0000269|PubMed:17425716}.
Miscellaneous Plants with decreased levels of farnesylcysteine lyase exhibit delayed germination and hypersensitivity to abscisic acid.
Similarity Belongs to the prenylcysteine oxidase family. {ECO:0000305}.
Subcellular Location Lysosome {ECO:0000250}.
Tissue Specificity Expressed in seedilings, flowers, stems, leaves and roots. {ECO:0000269|PubMed:17425716}.

Identical and Related Proteins

Unique RefSeq proteins for LMP010209 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
15237560 RefSeq NP_201196 500 farnesylcysteine lyase

Identical Sequences to LMP010209 proteins

Reference Database Accession Length Protein Name
GI:15237560 DBBJ BAB11039.1 500 unnamed protein product [Arabidopsis thaliana]
GI:15237560 GenBank AAL91144.1 500 unknown protein [Arabidopsis thaliana]
GI:15237560 GenBank AAM91116.1 500 unknown protein [Arabidopsis thaliana]
GI:15237560 gnl TAIR 500 farnesylcysteine lyase [Arabidopsis thaliana]
GI:15237560 SwissProt P57681.1 500 RecName: Full=Farnesylcysteine lyase; Flags: Precursor [Arabidopsis thaliana]

Related Sequences to LMP010209 proteins

Reference Database Accession Length Protein Name
GI:15237560 GenBank EFH42842.1 500 hypothetical protein ARALYDRAFT_496583 [Arabidopsis lyrata subsp. lyrata]
GI:15237560 GenBank EOA13243.1 500 hypothetical protein CARUB_v10026272mg [Capsella rubella]
GI:15237560 RefSeq XP_002866583.1 500 hypothetical protein ARALYDRAFT_496583 [Arabidopsis lyrata subsp. lyrata]
GI:15237560 RefSeq XP_010461143.1 501 PREDICTED: farnesylcysteine lyase-like [Camelina sativa]
GI:15237560 RefSeq XP_010444312.1 500 PREDICTED: farnesylcysteine lyase [Camelina sativa]
GI:15237560 RefSeq XP_010484153.1 500 PREDICTED: farnesylcysteine lyase-like [Camelina sativa]