Gene/Proteome Database (LMPD)

LMPD ID
LMP010220
Gene ID
829521
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
fatty acyl-CoA reductase CER4
Gene Symbol
CER4
Synonyms
ECERIFERUM 4; FAR3; FATTY ACID REDUCTASE 3; G7
Alternate Names
fatty acyl-CoA reductase CER4
Chromosome
4
EC Number
1.2.1.n2
Summary
Encodes an alcohol-forming fatty acyl-CoA reductase, involved in cuticular wax biosynthesis. Lines carrying recessive mutations are deficient in primary alcohol and have glossy stem surfaces.
Orthologs
View orthologs and multiple alignments for CER4

Proteins

fatty acyl-CoA reductase CER4
Refseq ID NP_567936
Protein GI 240256153
UniProt ID Q93ZB9
mRNA ID NM_119537
Length 493
RefSeq Status REVIEWED
MSTEMEVVSVLKYLDNKSILVVGAAGFLANIFVEKILRVAPNVKKLYLLLRASKGKSATQRFNDEILKKDLFKVLKEKYGPNLNQLTSEKITIVDGDICLEDLGLQDFDLAHEMIHQVDAIVNLAATTKFDERYDVALGINTLGALNVLNFAKRCAKVKILVHVSTAYVCGEKSGLIMETPYRMGETLNGTTGLDINYEKKLVQEKLDQLRVIGAAPETITETMKDLGLRRAKMYGWPNTYVFTKAMGEMMVGTKRENLSLVLLRPSIITSTFKEPFPGWTEGIRTIDSLAVGYGKGKLTCFLCDLDAVSDVMPADMVVNSILVSMAAQAGKQEEIIYHVGSSLRNPMKNSKFPELAYRYFSIKPWTNKEGKVVKVGAIEILSSMRSFHRYMTIRYLIALKGLELVNIILCKLFEKEFQYFNKKINFIFRLVDLYQPYLFFYGIFDDSNTEKLRKMVSKTGVENEMFYFDPKVLDWDDYFLNTHVIGLLKYVF

Gene Information

Entrez Gene ID
829521
Gene Name
fatty acyl-CoA reductase CER4
Gene Symbol
CER4
Species
Arabidopsis thaliana

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IDA:TAIR C endoplasmic reticulum
GO:0080019 IDA:TAIR F fatty-acyl-CoA reductase (alcohol-forming) activity
GO:0006629 IEA:UniProtKB-KW P lipid metabolic process
GO:0010025 IMP:TAIR P wax biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
ath00073 Cutin, suberine and wax biosynthesis
ath04146 Peroxisome
ko04146 Peroxisome

REACTOME Pathway Links

REACTOME Pathway ID Description
6254165 Plasmalogen biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR026055 Fatty acyl-CoA reductase
IPR013120 Male sterility, NAD-binding
IPR016040 NAD(P)-binding domain

UniProt Annotations

Entry Information

Gene Name
fatty acyl-CoA reductase CER4
Protein Entry
FACR3_ARATH
UniProt ID
Q93ZB9
Species
Arabidopsis

Comments

Comment Type Description
Catalytic Activity Hexadecanal + CoA + NADP(+) = hexadecanoyl-CoA + NADPH.
Disruption Phenotype Glossy stem wax. Major decreases in primary alcohols and wax esters, and slightly elevated levels of aldehydes, alkanes, secondary alcohols, and ketones. {ECO:0000269|PubMed:12228482, ECO:0000269|PubMed:16980563, ECO:0000269|PubMed:18470011}.
Function Catalyzes the reduction of fatty acyl-CoA to fatty alcohols. The preferred substrates are C24:0 and C26:0. May be unable to use saturated and monounsaturated C16 and C18 acyl-CoA as substrates. Involved in cuticular wax formation. {ECO:0000269|PubMed:16980563, ECO:0000269|PubMed:19062129}.
Sequence Caution Sequence=CAA20592.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAB80096.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Similarity Belongs to the fatty acyl-CoA reductase family. {ECO:0000305}.
Subcellular Location Endoplasmic reticulum {ECO:0000305|PubMed:16980563}.
Tissue Specificity Expressed in leaves, stems, flowers, siliques and roots. Detected in epidermal cells of leaves and stems, in trichomes and in the elongation zone of young roots. {ECO:0000269|PubMed:16980563}.

Identical and Related Proteins

Unique RefSeq proteins for LMP010220 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
240256153 RefSeq NP_567936 493 fatty acyl-CoA reductase CER4

Identical Sequences to LMP010220 proteins

Reference Database Accession Length Protein Name
GI:240256153 GenBank AAL15288.1 493 AT4g33790/T16L1_280 [Arabidopsis thaliana]
GI:240256153 GenBank AAL49822.1 493 putative male sterility 2 protein [Arabidopsis thaliana]
GI:240256153 GenBank ACX16097.1 493 Sequence 43098 from patent US 7569389
GI:240256153 GenBank AEE86278.1 493 fatty acyl-CoA reductase CER4 [Arabidopsis thaliana]
GI:240256153 SwissProt Q93ZB9.1 493 RecName: Full=Fatty acyl-CoA reductase 3; AltName: Full=Protein ECERIFERUM 4 [Arabidopsis thaliana]

Related Sequences to LMP010220 proteins

Reference Database Accession Length Protein Name
GI:240256153 EMBL CAA20592.1 463 male sterility 2-like protein, partial [Arabidopsis thaliana]
GI:240256153 EMBL CAB80096.1 480 male sterility 2-like protein [Arabidopsis thaliana]
GI:240256153 GenBank ACX18786.1 510 Sequence 46739 from patent US 7569389
GI:240256153 GenBank EFH43416.1 493 predicted protein [Arabidopsis lyrata subsp. lyrata]
GI:240256153 GenBank ESQ53764.1 494 hypothetical protein EUTSA_v10025005mg [Eutrema salsugineum]
GI:240256153 RefSeq XP_002867157.1 493 predicted protein [Arabidopsis lyrata subsp. lyrata]