Gene/Proteome Database (LMPD)
LMPD ID
LMP010349
Gene ID
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
geranylgeranyl pyrophosphate synthase 1
Gene Symbol
Synonyms
geranylgeranyl pyrophosphate synthase 1; GGPS1
Alternate Names
geranylgeranyl pyrophosphate synthase 1
Chromosome
4
EC Number
2.5.1.-
Summary
Encodes a protein with geranylgeranyl pyrophosphate synthase activity involved in isoprenoid biosynthesis. The enzyme appears to be targeted to the chloroplast in epidermal cells and guard cells of leaves, and in etioplasts in roots.
Orthologs
Proteins
| geranylgeranyl pyrophosphate synthase 1 | |
|---|---|
| Refseq ID | NP_195399 |
| Protein GI | 15234534 |
| UniProt ID | Q0WUL9 |
| mRNA ID | NM_119845 |
| Length | 371 |
| RefSeq Status | REVIEWED |
| MASVTLGSWIVVHHHNHHHPSSILTKSRSRSCPITLTKPISFRSKRTVSSSSSIVSSSVVTKEDNLRQSEPSSFDFMSYIITKAELVNKALDSAVPLREPLKIHEAMRYSLLAGGKRVRPVLCIAACELVGGEESTAMPAACAVEMIHTMSLIHDDLPCMDNDDLRRGKPTNHKVFGEDVAVLAGDALLSFAFEHLASATSSDVVSPVRVVRAVGELAKAIGTEGLVAGQVVDISSEGLDLNDVGLEHLEFIHLHKTAALLEASAVLGAIVGGGSDDEIERLRKFARCIGLLFQVVDDILDVTKSSKELGKTAGKDLIADKLTYPKIMGLEKSREFAEKLNREARDQLLGFDSDKVAPLLALANYIAYRQN | |
Gene Information
Entrez Gene ID
Gene Name
geranylgeranyl pyrophosphate synthase 1
Gene Symbol
Species
Arabidopsis thaliana
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0009507 | IDA:TAIR | C | chloroplast |
| GO:0009513 | IDA:TAIR | C | etioplast |
| GO:0004161 | IDA:TAIR | F | dimethylallyltranstransferase activity |
| GO:0004311 | IDA:TAIR | F | farnesyltranstransferase activity |
| GO:0004337 | IEA:UniProtKB-EC | F | geranyltranstransferase activity |
| GO:0046872 | IEA:UniProtKB-KW | F | metal ion binding |
| GO:0016117 | IEA:UniProtKB-KW | P | carotenoid biosynthetic process |
| GO:0045337 | IEA:UniProtKB-UniPathway | P | farnesyl diphosphate biosynthetic process |
| GO:0033384 | IEA:UniProtKB-UniPathway | P | geranyl diphosphate biosynthetic process |
| GO:0033386 | IEA:UniProtKB-UniPathway | P | geranylgeranyl diphosphate biosynthetic process |
| GO:0008299 | TAS:TAIR | P | isoprenoid biosynthetic process |
KEGG Pathway Links
Domain Information
UniProt Annotations
Entry Information
Gene Name
geranylgeranyl pyrophosphate synthase 1
Protein Entry
GGPP1_ARATH
UniProt ID
Species
Arabidopsis
Comments
| Comment Type | Description |
|---|---|
| Catalytic Activity | (2E,6E)-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate. |
| Catalytic Activity | Dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate. |
| Catalytic Activity | Geranyl diphosphate + isopentenyl diphosphate = diphosphate + (2E,6E)-farnesyl diphosphate. |
| Cofactor | Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250}; Note=Binds 3 Mg(2+) ions per subunit. {ECO:0000250}; |
| Function | Heterodimeric geranyl(geranyl)-diphosphate (GPP) synthase large subunit. In vitro, the large subunit catalyzes mainly the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate while the small subunit alone is inactive. Upon association of the two subunits, the product profile changes and the production of gerany-diphosphate is strongly increased. {ECO:0000269|PubMed:19482937}. |
| Pathway | Isoprenoid biosynthesis; farnesyl diphosphate biosynthesis; farnesyl diphosphate from geranyl diphosphate and isopentenyl diphosphate: step 1/1. |
| Pathway | Isoprenoid biosynthesis; geranyl diphosphate biosynthesis; geranyl diphosphate from dimethylallyl diphosphate and isopentenyl diphosphate: step 1/1. |
| Pathway | Isoprenoid biosynthesis; geranylgeranyl diphosphate biosynthesis; geranylgeranyl diphosphate from farnesyl diphosphate and isopentenyl diphosphate: step 1/1. |
| Similarity | Belongs to the FPP/GGPP synthase family. {ECO:0000305}. |
| Subcellular Location | Plastid, chloroplast {ECO:0000269|PubMed:10759500}. |
| Subunit | Monomer. Part of a heterodimeric geranyl(geranyl)diphosphate synthase. Interacts with GGR. {ECO:0000269|PubMed:19482937}. |
| Tissue Specificity | Expressed ubiquitously. {ECO:0000269|PubMed:10759500}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP010349 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 15234534 | RefSeq | NP_195399 | 371 | geranylgeranyl pyrophosphate synthase 1 |
Identical Sequences to LMP010349 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:15234534 | DBBJ | BAE99179.1 | 371 | geranylgeranyl pyrophosphate synthase [Arabidopsis thaliana] |
| GI:15234534 | EMBL | CAD57581.1 | 371 | unnamed protein product [Arabidopsis thaliana] |
| GI:15234534 | EMBL | CBF64646.1 | 371 | unnamed protein product [Arabidopsis thaliana] |
| GI:15234534 | EMBL | CBU89522.1 | 371 | unnamed protein product [Arabidopsis thaliana] |
| GI:15234534 | GenBank | AEE86705.1 | 371 | geranylgeranyl pyrophosphate synthase 1 [Arabidopsis thaliana] |
| GI:15234534 | GenBank | AGX56524.1 | 371 | Sequence 13386 from patent US 8541208 |
Related Sequences to LMP010349 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:15234534 | GenBank | AAA32797.1 | 371 | geranylgeranyl pyrophosphate synthase [Arabidopsis thaliana] |
| GI:15234534 | GenBank | AAM65107.1 | 371 | geranylgeranyl pyrophosphate synthase [Arabidopsis thaliana] |
| GI:15234534 | GenBank | EFH45280.1 | 379 | hypothetical protein ARALYDRAFT_490952 [Arabidopsis lyrata subsp. lyrata] |
| GI:15234534 | GenBank | AEL85593.1 | 371 | Sequence 1536 from patent US 7989676 |
| GI:15234534 | RefSeq | XP_002869021.1 | 379 | hypothetical protein ARALYDRAFT_490952 [Arabidopsis lyrata subsp. lyrata] |
| GI:15234534 | RefSeq | XP_010432134.1 | 372 | PREDICTED: heterodimeric geranylgeranyl pyrophosphate synthase large subunit 1, chloroplastic [Camelina sativa] |