Gene/Proteome Database (LMPD)

LMPD ID
LMP010353
Gene ID
820681
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
geranylgeranyl pyrophosphate synthase 3
Gene Symbol
GGPS3
Synonyms
geranylgeranyl pyrophosphate synthase 3; GGPS3
Alternate Names
geranylgeranyl pyrophosphate synthase 3
Chromosome
3
EC Number
2.5.1.-
Summary
Encodes a protein with geranylgeranyl pyrophosphate synthase activity involved in isoprenoid biosynthesis. The enzyme appears to be targeted to the chloroplast in epidermal cells and guard cells of leaves, and in etioplasts in roots.
Orthologs
View orthologs and multiple alignments for GGPS3

Proteins

geranylgeranyl pyrophosphate synthase 3
Refseq ID NP_188073
Protein GI 186510058
UniProt ID Q9LUD9
mRNA ID NM_112315
Length 360
RefSeq Status REVIEWED
MATTVHLSSFSLFIQSRGRRDNSISSVKSLKKRTGLSPSSALTSQGGRDMIPPEGKCNDHNSAFDFKLYMIRKAESVNAALDVSVPLREPLTVQEAVRYSLLAGGKRVRPLLCIAVCELVGGDEATAMSAACAVEMIHTSSLIHDDLPCMDNADLRRGKPTNHKVYGEDMAVLAGDALLALAFEHMTFVSSGLVAPERMIRAVVELARAIGTTGLVAGQMIDLASERLNPDKVGLEHLEFIHLHKTAALLEAAAVLGVIMGGGTEEEIEKLRKYARCIGLLFQVVDDILDVTKSTEELGKTAGKDVMAGKLTYPRLIGLERSKEVAEKLRREAEEQLLGFDPSKAAPLVALASYIACRHN

Gene Information

Entrez Gene ID
820681
Gene Name
geranylgeranyl pyrophosphate synthase 3
Gene Symbol
GGPS3
Species
Arabidopsis thaliana

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0009507 IEA:UniProtKB-KW C chloroplast
GO:0004161 IEA:UniProtKB-EC F dimethylallyltranstransferase activity
GO:0004311 IEA:UniProtKB-EC F farnesyltranstransferase activity
GO:0004337 IEA:UniProtKB-EC F geranyltranstransferase activity
GO:0046872 IEA:UniProtKB-KW F metal ion binding
GO:0016117 IEA:UniProtKB-KW P carotenoid biosynthetic process
GO:0045337 IEA:UniProtKB-UniPathway P farnesyl diphosphate biosynthetic process
GO:0033384 IEA:UniProtKB-UniPathway P geranyl diphosphate biosynthetic process
GO:0033386 IEA:UniProtKB-UniPathway P geranylgeranyl diphosphate biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
ath01110 Biosynthesis of secondary metabolites
ath01100 Metabolic pathways
ath00900 Terpenoid backbone biosynthesis
ko00900 Terpenoid backbone biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR008949 Isoprenoid synthase domain
IPR000092 Polyprenyl synthetase
IPR017446 Polyprenyl synthetase-related

UniProt Annotations

Entry Information

Gene Name
geranylgeranyl pyrophosphate synthase 3
Protein Entry
GGPP3_ARATH
UniProt ID
Q9LUD9
Species
Arabidopsis

Comments

Comment Type Description
Catalytic Activity (2E,6E)-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate.
Catalytic Activity Dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate.
Catalytic Activity Geranyl diphosphate + isopentenyl diphosphate = diphosphate + (2E,6E)-farnesyl diphosphate.
Cofactor Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250}; Note=Binds 3 Mg(2+) ions per subunit. {ECO:0000250};
Function Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate.
Pathway Isoprenoid biosynthesis; farnesyl diphosphate biosynthesis; farnesyl diphosphate from geranyl diphosphate and isopentenyl diphosphate: step 1/1.
Pathway Isoprenoid biosynthesis; geranyl diphosphate biosynthesis; geranyl diphosphate from dimethylallyl diphosphate and isopentenyl diphosphate: step 1/1.
Pathway Isoprenoid biosynthesis; geranylgeranyl diphosphate biosynthesis; geranylgeranyl diphosphate from farnesyl diphosphate and isopentenyl diphosphate: step 1/1.
Similarity Belongs to the FPP/GGPP synthase family. {ECO:0000305}.
Subcellular Location Plastid, chloroplast {ECO:0000269|PubMed:10759500}.
Subunit Monomer. {ECO:0000250}.
Tissue Specificity Mainly expressed in roots. {ECO:0000269|PubMed:10759500}.

Identical and Related Proteins

Unique RefSeq proteins for LMP010353 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
186510058 RefSeq NP_188073 360 geranylgeranyl pyrophosphate synthase 3

Identical Sequences to LMP010353 proteins

Reference Database Accession Length Protein Name
GI:186510058 GenBank AEE75537.1 360 geranylgeranyl pyrophosphate synthase 3 [Arabidopsis thaliana]

Related Sequences to LMP010353 proteins

Reference Database Accession Length Protein Name
GI:186510058 DBBJ BAB02387.1 360 geranylgeranyl pyrophosphate synthase [Arabidopsis thaliana]
GI:186510058 DBBJ BAC42571.1 360 putative geranylgeranyl pyrophosphate synthase GGPS3 [Arabidopsis thaliana]
GI:186510058 EMBL CBF64742.1 360 unnamed protein product [Arabidopsis thaliana]
GI:186510058 EMBL CBU89613.1 360 unnamed protein product [Arabidopsis thaliana]
GI:186510058 GenBank AGX56615.1 360 Sequence 13568 from patent US 8541208
GI:186510058 SwissProt Q9LUD9.1 360 RecName: Full=Geranylgeranyl pyrophosphate synthase 3, chloroplastic; Short=GGPP synthase 3; Short=GGPS3; AltName: Full=(2E,6E)-farnesyl diphosphate synthase 3; AltName: Full=Dimethylallyltranstransferase 3; AltName: Full=Farnesyl diphosphate synthase 3; AltName: Full=Farnesyltranstransferase 3; AltName: Full=Geranyltranstransferase 3; Flags: Precursor [Arabidopsis thaliana]