Gene/Proteome Database (LMPD)

LMPD ID
LMP010354
Gene ID
816379
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
geranylgeranyl pyrophosphate synthase 4
Gene Symbol
GGPS4
Synonyms
F24H14.2; geranylgeranyl pyrophosphate synthase 4; GGPS4
Alternate Names
geranylgeranyl pyrophosphate synthase 4
Chromosome
2
EC Number
2.5.1.-
Summary
Encodes an endoplasmic reticulum-targeted geranylgeranyl pyrophosphate synthase
Orthologs
View orthologs and multiple alignments for GGPS4

Proteins

geranylgeranyl pyrophosphate synthase 4
Refseq ID NP_179454
Protein GI 15224199
UniProt ID Q9SLG2
mRNA ID NM_127420
Length 372
RefSeq Status REVIEWED
MEAQNIFLYLLIVFLSLHFVFTTLKGRLSPANTRRLIRLLHIPIKSPVAAAIFARKDTREFLDSSIKLVNEEDDFGFSFDFKPYMISKAETINRALDEAIPLIEPLNIHKAMRYAILAGGKRVRPILCLAACELVGGEERLAIQAACAVEMIHTMSLIKDDLPCMDNDDLRRGKPTTHKVFGESVAILSGGALLALAFEHLTEADVSSKKMVRAVKELAKSIGTKGLVAGQAKDLSSEGLEQNDVGLEDLEYIHVHKTGSLLEASAVIGAVIGGGTEKEIEKVRNFARCIGLLFQVVDDILDETKSSEELGKTAGKDKVAGKLTYPKVIGVEKSKEFVEKLKRDAREHLQGFDSDKVKPLIALTNFIANRNH

Gene Information

Entrez Gene ID
816379
Gene Name
geranylgeranyl pyrophosphate synthase 4
Gene Symbol
GGPS4
Species
Arabidopsis thaliana

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IDA:TAIR C endoplasmic reticulum
GO:0004161 IEA:UniProtKB-EC F dimethylallyltranstransferase activity
GO:0004311 IDA:TAIR F farnesyltranstransferase activity
GO:0004337 IEA:UniProtKB-EC F geranyltranstransferase activity
GO:0046872 IEA:UniProtKB-KW F metal ion binding
GO:0016117 IEA:UniProtKB-KW P carotenoid biosynthetic process
GO:0045337 IEA:UniProtKB-UniPathway P farnesyl diphosphate biosynthetic process
GO:0033384 IEA:UniProtKB-UniPathway P geranyl diphosphate biosynthetic process
GO:0033386 IEA:UniProtKB-UniPathway P geranylgeranyl diphosphate biosynthetic process
GO:0008299 TAS:TAIR P isoprenoid biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
ath01110 Biosynthesis of secondary metabolites
ath01100 Metabolic pathways
ath00900 Terpenoid backbone biosynthesis
ko00900 Terpenoid backbone biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR008949 Isoprenoid synthase domain
IPR000092 Polyprenyl synthetase
IPR017446 Polyprenyl synthetase-related

UniProt Annotations

Entry Information

Gene Name
geranylgeranyl pyrophosphate synthase 4
Protein Entry
GGPP4_ARATH
UniProt ID
Q9SLG2
Species
Arabidopsis

Comments

Comment Type Description
Catalytic Activity (2E,6E)-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate.
Catalytic Activity Dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate.
Catalytic Activity Geranyl diphosphate + isopentenyl diphosphate = diphosphate + (2E,6E)-farnesyl diphosphate.
Cofactor Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250}; Note=Binds 3 Mg(2+) ions per subunit. {ECO:0000250};
Function Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate.
Pathway Isoprenoid biosynthesis; farnesyl diphosphate biosynthesis; farnesyl diphosphate from geranyl diphosphate and isopentenyl diphosphate: step 1/1.
Pathway Isoprenoid biosynthesis; geranyl diphosphate biosynthesis; geranyl diphosphate from dimethylallyl diphosphate and isopentenyl diphosphate: step 1/1.
Pathway Isoprenoid biosynthesis; geranylgeranyl diphosphate biosynthesis; geranylgeranyl diphosphate from farnesyl diphosphate and isopentenyl diphosphate: step 1/1.
Similarity Belongs to the FPP/GGPP synthase family. {ECO:0000305}.
Subcellular Location Endoplasmic reticulum {ECO:0000269|PubMed:10759500}.
Subunit Monomer. {ECO:0000250}.
Tissue Specificity Faintly expressed in flowers. {ECO:0000269|PubMed:10759500}.

Identical and Related Proteins

Unique RefSeq proteins for LMP010354 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
15224199 RefSeq NP_179454 372 geranylgeranyl pyrophosphate synthase 4

Identical Sequences to LMP010354 proteins

Reference Database Accession Length Protein Name
GI:15224199 EMBL CBF64650.1 372 unnamed protein product [Arabidopsis thaliana]
GI:15224199 EMBL CBU89526.1 372 unnamed protein product [Arabidopsis thaliana]
GI:15224199 GenBank ABE65826.1 372 geranylgeranyl pyrophosphate synthase/GGPP synthetase/farnesyltranstransferase [Arabidopsis thaliana]
GI:15224199 GenBank AEC06788.1 372 geranylgeranyl pyrophosphate synthase 4 [Arabidopsis thaliana]
GI:15224199 GenBank AGX56528.1 372 Sequence 13394 from patent US 8541208
GI:15224199 SwissProt Q9SLG2.1 372 RecName: Full=Geranylgeranyl pyrophosphate synthase 4; Short=GGPP synthase 4; Short=GGPS4; AltName: Full=(2E,6E)-farnesyl diphosphate synthase 4; AltName: Full=Dimethylallyltranstransferase 4; AltName: Full=Farnesyl diphosphate synthase 4; AltName: Full=Farnesyltranstransferase 4; AltName: Full=Geranyltranstransferase 4; Flags: Precursor [Arabidopsis thaliana]

Related Sequences to LMP010354 proteins

Reference Database Accession Length Protein Name
GI:15224199 GenBank ABK28498.1 373 unknown, partial [Arabidopsis thaliana]
GI:15224199 GenBank EFH62445.1 372 hypothetical protein ARALYDRAFT_480767 [Arabidopsis lyrata subsp. lyrata]
GI:15224199 RefSeq XP_002886186.1 372 hypothetical protein ARALYDRAFT_480767 [Arabidopsis lyrata subsp. lyrata]
GI:15224199 RefSeq XP_010414498.1 373 PREDICTED: LOW QUALITY PROTEIN: geranylgeranyl pyrophosphate synthase 4 [Camelina sativa]
GI:15224199 RefSeq XP_010467692.1 377 PREDICTED: geranylgeranyl pyrophosphate synthase 4-like [Camelina sativa]
GI:15224199 RefSeq XP_010489569.1 369 PREDICTED: geranylgeranyl pyrophosphate synthase 4-like [Camelina sativa]