Gene/Proteome Database (LMPD)
LMPD ID
LMP010419
Gene ID
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
glycerol-3-phosphate dehydrogenase [NAD(+)] GPDHC1
Gene Symbol
Synonyms
T32G6.6; T32G6_6
Alternate Names
glycerol-3-phosphate dehydrogenase [NAD(+)] GPDHC1
Chromosome
2
EC Number
1.1.1.8
Summary
Encodes a protein with NAD-dependent glycerol-3-phosphate (G3P) dehydrogenase which was shown to complement an Escherichia coli strain: BB20-14, auxotrophic for glycerol/G3P due to a loss-of-function mutation in the gpsA gene.
Orthologs
Proteins
glycerol-3-phosphate dehydrogenase [NAD(+)] GPDHC1 | |
---|---|
Refseq ID | NP_001031525 |
Protein GI | 79324881 |
UniProt ID | O22216 |
mRNA ID | NM_001036448 |
Length | 462 |
RefSeq Status | REVIEWED |
MVGSIEAKSLQSNGSVHHIGLNLEEKLDEFRRLLGKSEKDPLRIVSVGAGAWGSVFAALLQESYGGFRDKFQIRIWRRAGRAVDRETAEHLFEVINSREDILRRLIRRCAYLKYVEARLGDRTLYADEILKDGFCLNMVDTPLCPLKVVTNLQEAVWDADIVVNGLPSTETREVFEEISKYWKERITVPIIISLSKGIETALEPVPHIITPTKMIHQATGVPIDNVLYLGGPNIAAEIYNKEYANARICGAAKWRKPLAKFLRQPHFIVWDNSDLVTHEVMGGLKNVYAIGAGMVAALTNESATSKSVYFAHCTSEMIFITHLLAEEPEKLAGPLLADTYVTLLKGRNAWYGQMLAKGEINRDMGDSISGKGMIQGVSAVGAFYQLLSQSSLSILPSEEKKPVAPVESCPILKTLYKILITREQSTQAILQALRDETLNDPRDRIEIAQSHAFYRPSLLGQP |
Gene Information
Entrez Gene ID
Gene Name
glycerol-3-phosphate dehydrogenase [NAD(+)] GPDHC1
Gene Symbol
Species
Arabidopsis thaliana
Gene Ontology (GO Annotations)
GO ID | Source | Type | Description |
---|---|---|---|
GO:0005829 | IDA:TAIR | C | cytosol |
GO:0009331 | IEA:InterPro | C | glycerol-3-phosphate dehydrogenase complex |
GO:0004367 | IGI:TAIR | F | glycerol-3-phosphate dehydrogenase [NAD+] activity |
GO:0051287 | TAS:TAIR | F | NAD binding |
GO:0005975 | IEA:InterPro | P | carbohydrate metabolic process |
GO:0046168 | IEA:InterPro | P | glycerol-3-phosphate catabolic process |
GO:0006950 | IEA:UniProtKB-KW | P | response to stress |
BIOCYC Pathway Links
BIOCYC Pathway ID | Description |
---|---|
PWY-6118 | glycerol-3-phosphate shuttle |
Domain Information
InterPro Annotations
Accession | Description |
---|---|
IPR008927 | 6-phosphogluconate dehydrogenase, C-terminal-like |
IPR013328 | Dehydrogenase, multihelical |
IPR006168 | Glycerol-3-phosphate dehydrogenase, NAD-dependent |
IPR006109 | Glycerol-3-phosphate dehydrogenase, NAD-dependent, C-terminal |
IPR011128 | Glycerol-3-phosphate dehydrogenase, NAD-dependent, N-terminal |
IPR016040 | NAD(P)-binding domain |
UniProt Annotations
Entry Information
Gene Name
glycerol-3-phosphate dehydrogenase [NAD(+)] GPDHC1
Protein Entry
GPDHC_ARATH
UniProt ID
Species
Arabidopsis
Comments
Comment Type | Description |
---|---|
Catalytic Activity | sn-glycerol 3-phosphate + NAD(+) = glycerone phosphate + NADH. |
Disruption Phenotype | No visible phenotype under normal growth conditions, but mutant plants have increased NADH/NAD(+) ratios, decreased levels of glycerol-3-phosphate, and produce constitutive high levels of reactive oxygen species (ROS). {ECO:0000269|PubMed:16415206}. |
Function | Involved in cell redox homeostasis. Required for maintaining a steady state cellular NADH/NAD(+) ratio through a mitochondrial glycerol-3-phosphate redox shuttle. May function with the mitochondrial FAD-dependent glycerol-3-phosphate dehydrogenase SDP6 to shuttle reducing equivalents into the mitochondria for respiration. {ECO:0000269|PubMed:16415206}. |
Induction | By abscisic acid and salt and dehydration treatments. Down-regulated by hypoxia. {ECO:0000269|PubMed:16415206}. |
Similarity | Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. {ECO:0000305}. |
Subcellular Location | Cytoplasm, cytosol {ECO:0000250}. |
Tissue Specificity | Expressed in roots, leaves, flowers and siliques. {ECO:0000269|PubMed:16415206}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP010419 (as displayed in Record Overview)
Protein GI | Database | Accession | Length | Protein Name |
---|---|---|---|---|
79324881 | RefSeq | NP_001031525 | 462 | glycerol-3-phosphate dehydrogenase [NAD(+)] GPDHC1 |
Identical Sequences to LMP010419 proteins
Reference | Database | Accession | Length | Protein Name |
---|---|---|---|---|
GI:79324881 | GenBank | AAM14186.1 | 462 | putative glycerol-3-phosphate dehydrogenase [Arabidopsis thaliana] |
GI:79324881 | GenBank | AEC09996.1 | 462 | glycerol-3-phosphate dehydrogenase [NAD(+)] GPDHC1 [Arabidopsis thaliana] |
GI:79324881 | GenBank | AEC09997.1 | 462 | glycerol-3-phosphate dehydrogenase [NAD(+)] GPDHC1 [Arabidopsis thaliana] |
GI:79324881 | GenBank | AEC09998.1 | 462 | glycerol-3-phosphate dehydrogenase [NAD(+)] GPDHC1 [Arabidopsis thaliana] |
GI:79324881 | RefSeq | NP_850352.1 | 462 | glycerol-3-phosphate dehydrogenase [NAD(+)] GPDHC1 [Arabidopsis thaliana] |
GI:79324881 | SwissProt | O22216.1 | 462 | RecName: Full=Glycerol-3-phosphate dehydrogenase [NAD(+)] GPDHC1, cytosolic [Arabidopsis thaliana] |
Related Sequences to LMP010419 proteins
Reference | Database | Accession | Length | Protein Name |
---|---|---|---|---|
GI:79324881 | DBBJ | BAH20028.1 | 462 | AT2G41540 [Arabidopsis thaliana] |
GI:79324881 | GenBank | EFH56196.1 | 462 | GPDHC1 [Arabidopsis lyrata subsp. lyrata] |
GI:79324881 | GenBank | EOA27068.1 | 462 | hypothetical protein CARUB_v10023165mg [Capsella rubella] |
GI:79324881 | RefSeq | XP_002879937.1 | 462 | GPDHC1 [Arabidopsis lyrata subsp. lyrata] |
GI:79324881 | RefSeq | XP_006294170.1 | 462 | hypothetical protein CARUB_v10023165mg [Capsella rubella] |
GI:79324881 | RefSeq | XP_010505937.1 | 462 | PREDICTED: glycerol-3-phosphate dehydrogenase [NAD(+)] GPDHC1, cytosolic [Camelina sativa] |