Gene/Proteome Database (LMPD)
LMPD ID
LMP010452
Gene ID
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
guanine nucleotide-binding protein subunit gamma 1
Gene Symbol
Synonyms
AGG1; ATAGG1; GG1; Ggamma-subunit 1; HETEROTRIMERIC G PROTEIN GAMMA-SUBUNIT
Alternate Names
guanine nucleotide-binding protein subunit gamma 1
Chromosome
3
Summary
heterotrimeric G protein gamma-subunit (AGG1) mRNA
Orthologs
Proteins
Gene Information
Entrez Gene ID
Gene Name
guanine nucleotide-binding protein subunit gamma 1
Gene Symbol
Species
Arabidopsis thaliana
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005737 | IDA:UniProtKB | C | cytoplasm |
| GO:0005794 | IDA:UniProtKB | C | Golgi apparatus |
| GO:0005834 | IDA:UniProtKB | C | heterotrimeric G-protein complex |
| GO:0005886 | IDA:UniProtKB | C | plasma membrane |
| GO:0005525 | ISS:TAIR | F | GTP binding |
| GO:0004871 | IEA:UniProtKB-KW | F | signal transducer activity |
| GO:0010541 | IMP:TAIR | P | acropetal auxin transport |
| GO:0009817 | IMP:TAIR | P | defense response to fungus, incompatible interaction |
| GO:0007186 | IEA:InterPro | P | G-protein coupled receptor signaling pathway |
| GO:0048527 | IMP:TAIR | P | lateral root development |
| GO:0018345 | ISS:UniProtKB | P | protein palmitoylation |
| GO:0018342 | ISS:UniProtKB | P | protein prenylation |
| GO:0009845 | IMP:TAIR | P | seed germination |
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR015898 | G-protein gamma-like domain |
UniProt Annotations
Entry Information
Gene Name
guanine nucleotide-binding protein subunit gamma 1
Protein Entry
GG1_ARATH
UniProt ID
Species
Arabidopsis
Comments
| Comment Type | Description |
|---|---|
| Alternative Products | Event=Alternative initiation; Named isoforms=2; Name=1; IsoId=Q9FDX9-1; Sequence=Displayed; Name=2; IsoId=Q9FDX9-2; Sequence=VSP_044366; Note=Derived from EST data. No experimental confirmation available.; |
| Developmental Stage | In seedlings, first observed at the hypocotyl/root junction but later confined to the hypocotyl. In flowers, restricted to the stigma of mature flowers. In siliques, confined to the abscission zone. {ECO:0000269|PubMed:17468261, ECO:0000269|PubMed:18441222}. |
| Disruption Phenotype | Enhanced susceptibility to Alternaria brassicicola, Plectosphaerella cucumerina and Fusarium oxysporum associated with a disturbed expression of genes involved in cell wall metabolism (e.g. lower xylose content in cell walls). Reduced induction of the plant defensin gene PDF1.2, and decreased sensitivity to methyl jasmonate (MeJA). Hypersensitive to auxin- mediated induction of lateral roots, within the central cylinder, attenuating acropetally transported auxin signaling. Enhanced sensitivity to glucose and mannitol during seed germination. Abnormal roots architecture. {ECO:0000269|PubMed:17468261, ECO:0000269|PubMed:19948787, ECO:0000269|PubMed:20862254, ECO:0000269|PubMed:21980142, ECO:0000269|PubMed:22209167}. |
| Function | Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction. Involved in the abscisic acid (ABA) and ethylene signaling pathways. Regulates acropetal transport of auxin (IAA) in roots and hypocotyls, and thus modulates root architecture (e.g. lateral root formation). The heterotrimeric G- protein controls defense responses to necrotrophic and vascular fungi probably by modulating cell wall-related genes expression; involved in resistance to fungal pathogens such as Alternaria brassicicola, Plectosphaerella cucumerina and Fusarium oxysporum. {ECO:0000269|PubMed:17383830, ECO:0000269|PubMed:17468261, ECO:0000269|PubMed:19948787, ECO:0000269|PubMed:20862254, ECO:0000269|PubMed:21980142, ECO:0000269|PubMed:22209167}. |
| Induction | Induced locally by Alternaria brassicicola but systemically by Fusarium oxysporum. {ECO:0000269|PubMed:17468261}. |
| Interaction | P93397:- (xeno); NbExp=4; IntAct=EBI-1750878, EBI-1750986; P49177:GB1; NbExp=7; IntAct=EBI-1750878, EBI-1632851; |
| Similarity | Contains 1 G protein gamma domain. {ECO:0000305}. |
| Subcellular Location | Cell membrane. Golgi apparatus membrane. Golgi apparatus, trans-Golgi network membrane. Cytoplasm. Note=Localized to the cell membrane when attached to beta subunit GB1. Present in the cytoplasm when associated with NUDT7. |
| Subunit | G proteins are composed of 3 units, alpha, beta and gamma. Interacts with the beta subunit GB1. The dimer GB1-GG1 interacts with NDL1, NDL2 and NDL3. Binds to NUDT7. {ECO:0000269|PubMed:11121078, ECO:0000269|PubMed:17158913, ECO:0000269|PubMed:17468261, ECO:0000269|PubMed:19948787, ECO:0000269|PubMed:22068106}. |
| Tissue Specificity | Mostly expressed in seedlings (especially at the hypocotyl/root junction), young cauline leaves, open flowers, and floral stems, and, to a lower extent, in roots (restricted to the stele), rosette leaves (restricted to veins), siliques, and unopened floral buds. Also present in hydathods. {ECO:0000269|PubMed:11121078, ECO:0000269|PubMed:17468261, ECO:0000269|PubMed:18441222}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP010452 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 18412777 | RefSeq | NP_567147 | 98 | guanine nucleotide-binding protein subunit gamma 1 |
Identical Sequences to LMP010452 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:18412777 | DBBJ | BAD43578.1 | 98 | heterotrimeric G protein gamma-subunit (AGG1) [Arabidopsis thaliana] |
| GI:18412777 | GenBank | ABD38879.1 | 98 | At3g63420 [Arabidopsis thaliana] |
| GI:18412777 | GenBank | AEE80479.1 | 98 | Ggamma-subunit 1 [Arabidopsis thaliana] |
| GI:18412777 | GenBank | AEE80480.1 | 98 | Ggamma-subunit 1 [Arabidopsis thaliana] |
| GI:18412777 | RefSeq | NP_850741.1 | 98 | guanine nucleotide-binding protein subunit gamma 1 [Arabidopsis thaliana] |
| GI:18412777 | SwissProt | Q9FDX9.1 | 98 | RecName: Full=Guanine nucleotide-binding protein subunit gamma 1; AltName: Full=Ggamma-subunit 1; AltName: Full=Heterotrimeric G protein gamma-subunit 1; Short=AtAGG1; Flags: Precursor [Arabidopsis thaliana] |
Related Sequences to LMP010452 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:18412777 | EMBL | CAB87795.1 | 138 | putative protein [Arabidopsis thaliana] |
| GI:18412777 | GenBank | EFH52980.1 | 96 | G-protein gamma-subunit 1 [Arabidopsis lyrata subsp. lyrata] |
| GI:18412777 | GenBank | EOA25007.1 | 98 | hypothetical protein CARUB_v10018305mg [Capsella rubella] |
| GI:18412777 | RefSeq | XP_002876721.1 | 96 | G-protein gamma-subunit 1 [Arabidopsis lyrata subsp. lyrata] |
| GI:18412777 | RefSeq | XP_006292109.1 | 98 | hypothetical protein CARUB_v10018305mg [Capsella rubella] |
| GI:18412777 | RefSeq | XP_010512760.1 | 96 | PREDICTED: guanine nucleotide-binding protein subunit gamma 1-like [Camelina sativa] |